About   Help   FAQ
Prkd1 Gene Detail
Summary
  • Symbol
    Prkd1
  • Name
    protein kinase D1
  • Synonyms
    Pkcm, PKD1, Prkcm
  • Feature Type
    protein coding gene
  • IDs
    MGI:99879
    NCBI Gene: 18760
  • Gene Overview
    MyGene.info: PRKD1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr12:50341231-50649098 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      307868 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 21.78 cM, cytoband C1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    PRKD1, protein kinase D1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKD1, protein kinase D1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CHDED, PKCM, PKC-MU, PKD, PRKCM
  • Links
    NCBI Gene ID: 5587
    neXtProt AC: NX_Q15139
    UniProt: Q15139

  • Chr Location
    14q12; chr14:29576479-29927693 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial embryonic lethality. Mice homozygous for a knock-in allele display partial embryonic and perinatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002688 Ensembl Gene Model | MGI Sequence Detail 307868 C57BL/6J ±  kb
transcript ENSMUST00000002765 Ensembl | MGI Sequence Detail 3653 Not Applicable  
polypeptide ENSMUSP00000002765 Ensembl | MGI Sequence Detail 918 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    2927 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • EC
  • InterPro Domains
    IPR020454 Diacylglycerol/phorbol-ester binding
    IPR011993 PH-like domain superfamily
    IPR001849 Pleckstrin homology domain
    IPR017441 Protein kinase, ATP binding site
    IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    IPR015727 Protein kinase C mu-related
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain superfamily
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
less
  • All nucleic 45
    cDNA 41
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16670
References
more
  • Summaries
    All 78
    Developmental Gene Expression 7
    Gene Ontology 12
    Phenotypes 18
  • Earliest
    J:14175 Osada S, et al., A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. J Biol Chem. 1990 Dec 25;265(36):22434-40
  • Latest
    J:255151 Bergeron V, et al., Deletion of Protein Kinase D1 in Pancreatic beta-Cells Impairs Insulin Secretion in High-Fat Diet-Fed Mice. Diabetes. 2018 Jan;67(1):71-77

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/17/2018
MGI 6.11
The Jackson Laboratory