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Prkd1
Gene Detail
Symbol

Name
ID
Prkd1
protein kinase D1
MGI:99879
Synonyms
Pkcm, PKD1, Prkcm
Feature Type
protein coding gene
Genetic Map
Chromosome 12
21.78 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:50341231-50649223 bp, - strand
From Ensembl annotation of GRCm38

  307993 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRKD1
Protein SuperFamily: protein kinase C, mu/nu/D2 types
Gene Tree: Prkd1

Human
homologs
PRKD1, protein kinase D1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5587
neXtProt AC: NX_Q15139

Human Synonyms: PKCM, PKC-MU, PKD, PRKCM

Human Chr (Location): 14q11; chr14:29576479-29927693 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit partial embryonic lethality. Mice homozygous for a knock-in allele display partial embryonic and perinatal lethality.
 
Interactions
Prkd1 interacts with 252 markers (Mir7-2, Mir7b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process angiogenesis, apoptotic process, ...
Component cell, cell-cell junction, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (141)    Tissues (106)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 66
Western blot 6
RT-PCR 66
cDNA source data(41)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prkd1 ; ZFIN prkd1    NEW 
Molecular
reagents
All nucleic(45) cDNA(41) Primer pair(4)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000002688 (Evidence)
Entrez Gene 18760 (Evidence)
UniGene 133719
DFCI TC1584137
DoTS DT.97410218
NIA Mouse Gene Index U033930
EC 2.7.11.13
Consensus CDS Project CCDS49059.1
International Mouse Phenotyping Consortium Status Prkd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002688 Ensembl Gene Model | MGI Sequence Detail 307993 C57BL/6J ±  kb
transcript ENSMUST00000002765 Ensembl | MGI Sequence Detail 3778 Not Applicable 
polypeptide ENSMUSP00000002765 Ensembl | MGI Sequence Detail 918 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(14) UniProt(1)
Polymorphisms
SNPs within 2kb(2946 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2950)
Protein-related
information
ResourceIDDescription
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR015727 Protein kinase C mu-related
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013236 serine/threonine-protein kinase D1
References
(Earliest) J:14175 Osada S, et al., A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. J Biol Chem. 1990 Dec 25;265(36):22434-40
(Latest) J:209306 Candasamy AJ, et al., Phosphoregulation of the titin-cap protein telethonin in cardiac myocytes. J Biol Chem. 2014 Jan 17;289(3):1282-93
All references(53)
Other
accession IDs
MGD-MRK-16670

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory