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Prkd1 Gene Detail
Summary
  • Symbol
    Prkd1
  • Name
    protein kinase D1
  • Synonyms
    Pkcm, PKD1, Prkcm
  • Feature Type
    protein coding gene
  • IDs
    MGI:99879
    NCBI Gene: 18760
  • Gene Overview
    MyGene.info: PRKD1
Location & Maps
more
  • Sequence Map
    Chr12:50341231-50649223 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      307993 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PRKD1, protein kinase D1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKD1, protein kinase D1
    Orthology source: HomoloGene
  • Synonyms
    PKCM, PKC-MU, PKD, PRKCM
  • Links
    NCBI Gene ID: 5587
    neXtProt AC: NX_Q15139

  • Chr Location
    14q11; chr14:29576479-29927693 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit partial embryonic lethality. Mice homozygous for a knock-in allele display partial embryonic and perinatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002688 Ensembl Gene Model | MGI Sequence Detail 307993 C57BL/6J ±  kb
transcript ENSMUST00000002765 Ensembl | MGI Sequence Detail 3778 Not Applicable  
polypeptide ENSMUSP00000002765 Ensembl | MGI Sequence Detail 918 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2927 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 45
    cDNA 41
    Primer pair 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16670
References
more
  • Summaries
    All 54
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:14175 Osada S, et al., A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. J Biol Chem. 1990 Dec 25;265(36):22434-40
  • Latest
    J:221790 Liou GY, et al., Protein kinase D1 drives pancreatic acinar cell reprogramming and progression to intraepithelial neoplasia. Nat Commun. 2015;6:6200

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory