Prkd1
Gene Detail

Symbol Name ID

Prkd1 protein kinase D1 MGI:99879

Synonyms

Pkcm, PKD1, Prkcm

Feature Type

protein coding gene

Genetic Map

Chromosome 12

21.78 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr12:50341231-50649223 bp, - strand From NCBI annotation of GRCm38   307993 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: protein kinase C, mu/nu/D2 types
Gene Tree: Prkd1

Human homologs

Human Homolog		PRKD1, protein kinase D1
NCBI Gene ID		5587
neXtProt AC		NX_Q15139
Human Synonyms		PKCM, PKC-MU, PKD, PRKCM
Human Chr (Location)		14q11; chr14:30045685-30396899 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mice homozygous for a knock-out allele exhibit partial embryonic lethality. Mice homozygous for a knock-in allele display partial embryonic and perinatal lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (59 annotations)

Process	angiogenesis, apoptotic process, ...
Component	cell-cell junction, cell cortex, ...
Function	ATP binding, identical protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (125)    Tissues (98)    Images (29)
Theiler Stages: 13, 15, 17, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	66
RT-PCR	59

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) cDNA(41) Primer pair(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000002688 (Evidence)
Entrez Gene	18760 (Evidence)
UniGene	133719
DFCI	TC1584137
DoTS	DT.97410218
NIA Mouse Gene Index	U033930
EC	2.7.11.13
Consensus CDS Project	CCDS49059.1
International Mouse Knockout Project Status	Prkd1

Sequences

Length	Strain/Species
genomic	18760	NCBI Gene Model | MGI Sequence Detail	307993	C57BL/6J
transcript	NM_008858	RefSeq | MGI Sequence Detail	3778	Not Specified
polypeptide	Q62101	UniProt | EBI | MGI Sequence Detail	918	Not Applicable

All sequences(11) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(1946 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020454	Diacylglycerol/phorbol-ester binding
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro	IPR015727	Protein kinase C mu-related
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000013236	serine/threonine-protein kinase D1

Graphical View of Protein Domain Structure

References

(Earliest) J:14175 Osada S, et al., A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. J Biol Chem. 1990 Dec 25;265(36):22434-40
(Latest) J:190972 Ittner A, et al., Regulation of PTEN activity by p38delta-PKD1 signaling in neutrophils confers inflammatory responses in the lung. J Exp Med. 2012 Nov 19;209(12):2229-46
All references(50)

Other accession IDs

MGD-MRK-16670