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Prkd1
Gene Detail
 Symbol
Name
ID
Prkd1
protein kinase D1
MGI:99879
Synonyms Pkcm, PKD1, Prkcm
Feature Type protein coding gene
Genetic Map
Chromosome 12
21.78 cM, cytoband C1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:50341231-50649223 bp, - strand
From NCBI annotation of GRCm38

  307993 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55680  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protein kinase C, mu/nu/D2 types
Gene Tree: Prkd1

Human
homologs
Human Homolog PRKD1, protein kinase D1
NCBI Gene ID 5587
neXtProt AC  NX_Q15139
Human Synonyms  PKCM, PKC-MU, PKD, PRKCM
Human Chr (Location)  14q11; chr14:29576479-29927693 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit partial embryonic lethality. Mice homozygous for a knock-in allele display partial embryonic and perinatal lethality.
 
Interactions
Prkd1 interacts with 252 markers (Mir7-2, Mir7b, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process angiogenesis, apoptotic process, ...
Component cell, cell-cell junction, ...
Function ATP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (141)    Tissues (106)    Images (40)
Theiler Stages: 2, 3, 5, 13, 15, 17, 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 3
RNA in situ 66
Western blot 6
RT-PCR 66
cDNA source data(41)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(45) cDNA(41) Primer pair(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000002688 (Evidence)
Entrez Gene18760 (Evidence)
UniGene133719
DFCITC1584137
DoTSDT.97410218
NIA Mouse Gene IndexU033930
EC2.7.11.13
Consensus CDS ProjectCCDS49059.1
International Mouse Knockout Project StatusPrkd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18760 NCBI Gene Model | MGI Sequence Detail 307993 C57BL/6J ±  kb
transcript NM_008858 RefSeq | MGI Sequence Detail 3778 Not Specified 
polypeptide Q62101 UniProt | EBI | MGI Sequence Detail 918 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(14) UniProt(1)
Polymorphisms SNPs within 2kb(2946 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2950)
Protein-related
information
ResourceIDDescription
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR015727 Protein kinase C mu-related
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013236 serine/threonine-protein kinase D1
Graphical View of Protein Domain Structure
References (Earliest) J:14175 Osada S, et al., A phorbol ester receptor/protein kinase, nPKC eta, a new member of the protein kinase C family predominantly expressed in lung and skin. J Biol Chem. 1990 Dec 25;265(36):22434-40
(Latest) J:207335 Rashel M, et al., Protein kinase d1 has a key role in wound healing and skin carcinogenesis. J Invest Dermatol. 2014 Apr;134(4):902-9
All references(54)
Other
accession IDs
MGD-MRK-16670

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory