Phenotypes Associated with This Genotype

Genotype
MGI:8280560

• Allelic Composition: Prkd1^em1Dlp/Prkd1⁺
• Genetic Background: C57BL/6J-Prkd1^em1Dlp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:358380 )

N • normal locomotor behavior in accelerated rotarod, open field, Porsolt forced swimming, and gait tests

N • normal response in Von Frey and hotplate tests

increased susceptibility to induction of seizure by inducing agent ( J:358380 )

• increased susceptibility to and severity of kainic-acid-induced seizures

nervous system

nervous system phenotype ( J:358380 )

N • normal brain weight

increased susceptibility to induction of seizure by inducing agent ( J:358380 )

• increased susceptibility to and severity of kainic-acid-induced seizures

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
juvenile myoclonic epilepsy		DOID:4890	OMIM:254770	J:358380