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Bax
Gene Detail
Symbol

Name
ID
Bax
BCL2-associated X protein
MGI:99702
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.32 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr7:45461695-45466898 bp, - strand
From Ensembl annotation of GRCm38

  5204 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BAX
Protein SuperFamily: apoptosis regulator BAX
Gene Tree: Bax

Human
homologs
BAX, Bcl2-associated X protein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 581
neXtProt AC: NX_Q07812

Human Synonyms: BCL2L4

Human Chr (Location): 19q13.3-q13.4; chr19:48954860-48961798 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(41) : Gene trapped(35) Targeted(6)
 
Homozygous null mutants display hyperplasia of thymocytes and B cells, reproductive failure with abnormal germ cells and gonadal morphology, and reduced cell death in the CNS and PNS. Female mutants exhibit a prolonged ovarian lifespan.
 
Interactions
Bax interacts with 24 markers (Mir17, Mir20b, Mir32, ...)
Expression
Literature Summary: (88 records)
Data Summary: Results (304)    Tissues (127)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 93
Northern blot 27
Western blot 54
RT-PCR 119
RNase protection 5
cDNA source data(49)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bax    NEW 
Molecular
reagents
All nucleic(61) Genomic(2) cDNA(49) Primer pair(9) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000003873 (Evidence)
Entrez Gene 12028 (Evidence)
UniGene 19904
DFCI TC1578578, TC1604578, TC1608700, TC1689860
DoTS DT.489903, DT.91445223
NIA Mouse Gene Index U335981
PDB 2XA0
Consensus CDS Project CCDS21246.1
International Mouse Phenotyping Consortium Status Bax
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003873 Ensembl Gene Model | MGI Sequence Detail 5204 C57BL/6J ±  kb
transcript ENSMUST00000033093 Ensembl | MGI Sequence Detail 869 Not Applicable 
polypeptide ENSMUSP00000033093 Ensembl | MGI Sequence Detail 192 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(4)
Polymorphisms
RFLP(2) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026304 Apoptosis regulator BAX
InterPro IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site
InterPro IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site
InterPro IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
InterPro IPR002475 Bcl2-like
InterPro IPR026298 Blc2 family
Protein Ontology PR:000002193 apoptosis regulator BAX
References
(Earliest) J:19076 Oltvai ZN, et al., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19
(Latest) J:220019 Schwarzer C, et al., Paraoxonase 2 Serves a Proapopotic Function in Mouse and Human Cells in Response to the Pseudomonas aeruginosa Quorum-sensing Molecule N-(3-Oxododecanoyl)-homoserine Lactone. J Biol Chem. 2015 Mar 13;290(11):7247-58
All references(541)
Other
accession IDs
MGD-MRK-16487

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory