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Bax Gene Detail
Summary
  • Symbol
    Bax
  • Name
    BCL2-associated X protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:99702
    NCBI Gene: 12028
  • Gene Overview
    MyGene.info: BAX
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:45461697-45466898 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.32 cM, cytoband B5
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99702
 protein coding gene Chr7:45461695-45466903 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032224
 protein coding gene Chr7:45727314-45732515 (-)
A/J MGP_AJ_G0032203
 protein coding gene Chr7:44849916-44855117 (-)
AKR/J MGP_AKRJ_G0032139
 protein coding gene Chr7:46092173-46097376 (-)
BALB/cJ MGP_BALBcJ_G0032215
 protein coding gene Chr7:44837689-44842890 (-)
C3H/HeJ MGP_C3HHeJ_G0031930
 protein coding gene Chr7:46577103-46582304 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032707
 protein coding gene Chr7:47998698-48003901 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029721
 protein coding gene Chr7:47396729-47402298 (-)
CAST/EiJ MGP_CASTEiJ_G0031259
 protein coding gene Chr7:38001628-38006814 (-)
CBA/J MGP_CBAJ_G0031895
 protein coding gene Chr7:49580797-49586000 (-)
DBA/2J MGP_DBA2J_G0032053
 protein coding gene Chr7:44512282-44517483 (-)
FVB/NJ MGP_FVBNJ_G0032004
 protein coding gene Chr7:44298705-44303908 (-)
LP/J MGP_LPJ_G0032131
 protein coding gene Chr7:46424463-46429666 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032041
 protein coding gene Chr7:48282764-48287967 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032723
 protein coding gene Chr7:45308561-45313764 (-)
PWK/PhJ MGP_PWKPhJ_G0030981
 protein coding gene Chr7:37889272-37894484 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030819
 protein coding gene Chr7:33312581-33317823 (-)
WSB/EiJ MGP_WSBEiJ_G0031376
 protein coding gene Chr7:45801041-45807336 (-)



Homology
more
  • Human Ortholog
    BAX, BCL2 associated X, apoptosis regulator
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BAX, BCL2 associated X, apoptosis regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCL2L4
  • Links
    NCBI Gene ID: 581
    neXtProt AC: NX_Q07812
    UniProt: Q07812

  • Chr Location
    19q13.33; chr19:48954825-48961798 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    2 with human BAX associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 4 alleles in 7 genetic backgrounds
    114 phenotypes from multigenic genotypes
    417 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants display hyperplasia of thymocytes and B cells, reproductive failure with abnormal germ cells and gonadal morphology, and reduced cell death in the CNS and PNS. Female mutants exhibit a prolonged ovarian lifespan.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    229
  • GO References
    122
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    957
  • Tissues
    146
  • cDNA Data
    50
  • Literature Summary
    122
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003873 Ensembl Gene Model | MGI Sequence Detail 5202 C57BL/6J ±  kb
    transcript ENSMUST00000033093 Ensembl | MGI Sequence Detail 867 Not Applicable  
    polypeptide ENSMUSP00000033093 Ensembl | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 65
      Genomic 2
      cDNA 50
      Primer pair 12
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16487
    References
    more
    • Summaries
      All 722
      Developmental Gene Expression 122
      Gene Ontology 122
      Phenotypes 417
    • Earliest
      J:19076 Oltvai ZN, et al., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19
    • Latest
      J:297108 Carriere CH, et al., The gamma-Protocadherins Regulate the Survival of GABAergic Interneurons during Developmental Cell Death. J Neurosci. 2020 Nov 4;40(45):8652-8668
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    01/12/2021
    MGI 6.16     		The Jackson Laboratory