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Bax Gene Detail
Summary
  • Symbol
    Bax
  • Name
    BCL2-associated X protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:99702
    NCBI Gene: 12028
  • Gene Overview
    MyGene.info: BAX
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:45461697-45466898 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      5202 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.32 cM, cytoband B5
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    BAX, BCL2 associated X, apoptosis regulator
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BAX, BCL2 associated X, apoptosis regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCL2L4
  • Links
    NCBI Gene ID: 581
    neXtProt AC: NX_Q07812
    UniProt: Q07812

  • Chr Location
    19q13.33; chr19:48954825-48961798 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 4 alleles in 7 genetic backgrounds
    113 phenotypes from multigenic genotypes
    370 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants display hyperplasia of thymocytes and B cells, reproductive failure with abnormal germ cells and gonadal morphology, and reduced cell death in the CNS and PNS. Female mutants exhibit a prolonged ovarian lifespan.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    223
  • GO References
    123
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    308
  • Tissues
    133
  • cDNA Data
    50
  • Literature Summary
    99
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000059409 VEGA Gene Model | MGI Sequence Detail 5202 C57BL/6J ±  kb
    transcript OTTMUST00000145825 VEGA | MGI Sequence Detail 867 Not Applicable  
    polypeptide OTTMUSP00000075975 VEGA | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      43 from dbSNP Build 142
    • RFLP
      2
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 2
      cDNA 50
      Primer pair 11
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16487
    References
    more
    • Summaries
      All 656
      Developmental Gene Expression 99
      Gene Ontology 123
      Phenotypes 370
    • Earliest
      J:19076 Oltvai ZN, et al., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19
    • Latest
      J:262422 Wong FK, et al., Pyramidal cell regulation of interneuron survival sculpts cortical networks. Nature. 2018 May;557(7707):668-673
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory