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Bax Gene Detail
Summary
  • Symbol
    Bax
  • Name
    BCL2-associated X protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:99702
    NCBI Gene: 12028
  • Gene Overview
    MyGene.info: BAX
Location & Maps
more
  • Sequence Map
    Chr7:45461697-45466898 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      5202 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.32 cM, cytoband B5
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    BAX, BCL2 associated X, apoptosis regulator
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BAX, BCL2 associated X, apoptosis regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCL2L4
  • Links
    NCBI Gene ID: 581
    neXtProt AC: NX_Q07812

  • Chr Location
    19q13.3-q13.4; chr19:48954860-48961798 (+)  GRCh38.p2
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 4 alleles in 7 genetic backgrounds
    112 phenotypes from multigenic genotypes
    342 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    42
  • Gene trapped
    35
  • Targeted
    6
  • Transgenic
    1
Homozygous null mutants display hyperplasia of thymocytes and B cells, reproductive failure with abnormal germ cells and gonadal morphology, and reduced cell death in the CNS and PNS. Female mutants exhibit a prolonged ovarian lifespan.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    215
  • GO References
    117
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    305
  • Tissues
    128
  • cDNA Data
    49
  • Literature Summary
    90
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003873 Ensembl Gene Model | MGI Sequence Detail 5202 C57BL/6J ±  kb
transcript ENSMUST00000033093 Ensembl | MGI Sequence Detail 867 Not Applicable  
polypeptide ENSMUSP00000033093 Ensembl | MGI Sequence Detail 192 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    43 from dbSNP Build 142
  • RFLP
    2
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000002193 apoptosis regulator BAX
  • PDB
    2XA0
  • InterPro Domains
    IPR026304 Apoptosis regulator BAX
    IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site
    IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site
    IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
    IPR002475 Bcl2-like
    IPR026298 Blc2 family
Molecular
Reagents
less
  • All nucleic 62
    Genomic 2
    cDNA 49
    Primer pair 10
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16487
References
more
  • Summaries
    All 566
    Developmental Gene Expression 90
    Gene Ontology 117
    Phenotypes 342
  • Earliest
    J:19076 Oltvai ZN, et al., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19
  • Latest
    J:232796 Xu Z, et al., BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells. Leukemia. 2016 Jul;30(7):1531-41
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/20/2016
MGI 6.05 		The Jackson Laboratory