About   Help   FAQ
Bax Gene Detail
Summary
  • Symbol
    Bax
  • Name
    BCL2-associated X protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:99702
    NCBI Gene: 12028
  • Gene Overview
    MyGene.info: BAX
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:45461697-45466898 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      5202 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 29.32 cM, cytoband B5
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    BAX, BCL2 associated X, apoptosis regulator
  • Vertebrate Orthologs
    9
  • Human Ortholog
    BAX, BCL2 associated X, apoptosis regulator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCL2L4
  • Links
    NCBI Gene ID: 581
    neXtProt AC: NX_Q07812
    UniProt: Q07812

  • Chr Location
    19q13.33; chr19:48954825-48961798 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 4 alleles in 7 genetic backgrounds
    112 phenotypes from multigenic genotypes
    365 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants display hyperplasia of thymocytes and B cells, reproductive failure with abnormal germ cells and gonadal morphology, and reduced cell death in the CNS and PNS. Female mutants exhibit a prolonged ovarian lifespan.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    223
  • GO References
    123
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    306
  • Tissues
    130
  • cDNA Data
    49
  • Literature Summary
    98
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000059409 VEGA Gene Model | MGI Sequence Detail 5202 C57BL/6J ±  kb
    transcript OTTMUST00000145825 VEGA | MGI Sequence Detail 867 Not Applicable  
    polypeptide OTTMUSP00000075975 VEGA | MGI Sequence Detail 192 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      43 from dbSNP Build 142
    • RFLP
      2
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      Genomic 2
      cDNA 49
      Primer pair 10
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16487
    References
    more
    • Summaries
      All 648
      Developmental Gene Expression 98
      Gene Ontology 123
      Phenotypes 365
    • Earliest
      J:19076 Oltvai ZN, et al., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19
    • Latest
      J:257634 Yungher BJ, et al., Regenerative Responses and Axon Pathfinding of Retinal Ganglion Cells in Chronically Injured Mice. Invest Ophthalmol Vis Sci. 2017 Mar 1;58(3):1743-1750
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory