Bax MGI Mouse Gene Detail - MGI:99702 - BCL2-associated X protein

Symbol

Bax
Name

BCL2-associated X protein

Feature Type

protein coding gene
IDs

MGI:99702
NCBI Gene: 12028
Gene Overview

MyGene.info: BAX
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr7:45461697-45466898 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 29.32 cM, cytoband B5
Mapping Data

11 experiments

SNPs within 2kb

43 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99702	protein coding gene	Chr7:45461695-45468205 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032224	protein coding gene	Chr7:45727314-45732515 (-)
A/J	MGP_AJ_G0032203	protein coding gene	Chr7:44849916-44855117 (-)
AKR/J	MGP_AKRJ_G0032139	protein coding gene	Chr7:46092173-46097376 (-)
BALB/cJ	MGP_BALBcJ_G0032215	protein coding gene	Chr7:44837689-44842890 (-)
C3H/HeJ	MGP_C3HHeJ_G0031930	protein coding gene	Chr7:46577103-46582304 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0032707	protein coding gene	Chr7:47998698-48003901 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029721	protein coding gene	Chr7:47396729-47402298 (-)
CAST/EiJ	MGP_CASTEiJ_G0031259	protein coding gene	Chr7:38001628-38006814 (-)
CBA/J	MGP_CBAJ_G0031895	protein coding gene	Chr7:49580797-49586000 (-)
DBA/2J	MGP_DBA2J_G0032053	protein coding gene	Chr7:44512282-44517483 (-)
FVB/NJ	MGP_FVBNJ_G0032004	protein coding gene	Chr7:44298705-44303908 (-)
LP/J	MGP_LPJ_G0032131	protein coding gene	Chr7:46424463-46429666 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032041	protein coding gene	Chr7:48282764-48287967 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0032723	protein coding gene	Chr7:45308561-45313764 (-)
PWK/PhJ	MGP_PWKPhJ_G0030981	protein coding gene	Chr7:37889272-37894484 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0030819	protein coding gene	Chr7:33312581-33317823 (-)
WSB/EiJ	MGP_WSBEiJ_G0031376	protein coding gene	Chr7:45801041-45807336 (-)

Human Ortholog

BAX, BCL2 associated X, apoptosis regulator

Vertebrate Orthologs

9

Human Ortholog

BAX, BCL2 associated X, apoptosis regulator
Orthology source: HomoloGene, HGNC
Synonyms

BCL2L4
Links

HGNC:959

NCBI Gene ID: 581

neXtProt AC: NX_Q07812

UniProt: Q07812
Chr Location

19q13.33; chr19:48954825-48961798 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7242
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: BAX
Protein SuperFamily

apoptosis regulator BAX
Gene Tree

Bax

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Phenotype Summary

40 phenotypes from 4 alleles in 7 genetic backgrounds
113 phenotypes from multigenic genotypes
380 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

25
Gene trapped

18
Targeted

6
Transgenic

1
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutants display hyperplasia of thymocytes and B cells, reproductive failure with abnormal germ cells and gonadal morphology, and reduced cell death in the CNS and PNS. Female mutants exhibit a prolonged ovarian lifespan.

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All GO Annotations

234
GO References

123

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

320
Tissues

144
cDNA Data

50
Literature Summary

106

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase bax

ZFIN baxa, baxb

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Bax interacts with 24 markers (Mir17, Mir20b, Mir32, ...) View All

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All Sequences

58
RefSeq

6
UniProt

9
CCDS

CCDS21246.1
UniGene

19904

Ensembl

ENSMUSG00000003873 (Evidence)
NCBI Gene

12028

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003873	Ensembl Gene Model \| MGI Sequence Detail	5202	C57BL/6J	± kb
transcript	ENSMUST00000033093	Ensembl \| MGI Sequence Detail	867	Not Applicable
polypeptide	ENSMUSP00000033093	Ensembl \| MGI Sequence Detail	192	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000002193 apoptosis regulator BAX

(term hierarchy)
PDB

2XA0, 5W62
InterPro Domains

IPR026304 Apoptosis regulator BAX

IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site

IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site

IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site

IPR002475 Bcl2-like

IPR026298 Blc2 family

IPR036834 Blc2-like superfamily

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All nucleic 64

Genomic 2

cDNA 50

Primer pair 11

Other 1

Microarray probesets 3

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MGD-MRK-16487

Summaries

All 673

Developmental Gene Expression 106

Gene Ontology 123

Phenotypes 380
Earliest

J:19076 Oltvai ZN, et al., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19
Latest

J:272566 Yang R, et al., CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development. Development. 2019 Jan 25;146(2)

TSS for Bax:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr72410	Chr7:45466894-45466901 (-)	0 bp
Tssr72409	Chr7:45466872-45466883 (-)	20 bp
Tssr72408	Chr7:45466793-45466854 (-)	74 bp
Tssr72407	Chr7:45466779-45466790 (-)	113 bp
Tssr72406	Chr7:45466550-45466587 (-)	329 bp
Tssr72405	Chr7:45466512-45466542 (-)	371 bp
Tssr72404	Chr7:45466471-45466487 (-)	419 bp
Tssr72403	Chr7:45466378-45466428 (-)	495 bp
Tssr72402	Chr7:45466272-45466298 (-)	613 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 04/16/2019 MGI 6.13