Bax
Gene Detail

Symbol Name ID

Bax BCL2-associated X protein MGI:99702

Feature Type

protein coding gene

Genetic Map

Chromosome 7

29.32 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr7:45461695-45466898 bp, - strand From NCBI annotation of GRCm38   5204 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: apoptosis regulator BAX
Gene Tree: Bax

Human homologs

Human Homolog		BAX, Bcl2-associated X protein
NCBI Gene ID		581
neXtProt AC		NX_Q07812
Human Synonyms		BCL2L4
Human Chr (Location)		19q13.3-q13.4; chr19:48954860-48961798 (+)  GRCh38

Alleles and phenotypes

All alleles(41) : Gene trapped(35) Targeted(6)
 

Homozygous null mutants display hyperplasia of thymocytes and B cells, reproductive failure with abnormal germ cells and gonadal morphology, and reduced cell death in the CNS and PNS. Female mutants exhibit a prolonged ovarian lifespan.

 

Gene Ontology (GO) classifications

All GO classifications: (215 annotations)

Process	activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, ...
Component	BAX complex, Bcl-2 family protein complex, ...
Function	BH3 domain binding, BH domain binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (86 records)

Data Summary: Results (331)    Tissues (126)    Images (28)
Theiler Stages: 1, 2, 3, 4, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	93
Northern blot	49
Western blot	54
RT-PCR	124
RNase protection	5

cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(61) Genomic(2) cDNA(49) Primer pair(9) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000003873 (Evidence)
Entrez Gene	12028 (Evidence)
UniGene	19904
DFCI	TC1578578, TC1604578, TC1608700, TC1689860
DoTS	DT.489903, DT.91445223
NIA Mouse Gene Index	U335981
PDB	2XA0
Consensus CDS Project	CCDS21246.1
International Mouse Knockout Project Status	Bax

Sequences

Length	Strain/Species
genomic	12028	NCBI Gene Model | MGI Sequence Detail	5204	C57BL/6J
transcript	NM_007527	RefSeq | MGI Sequence Detail	869	C57BL/6
polypeptide	Q07813	UniProt | EBI | MGI Sequence Detail	192	Not Applicable

All sequences(30) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(2) : SNPs within 2kb(43 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR026304	Apoptosis regulator BAX
InterPro	IPR020717	Apoptosis regulator, Bcl-2, BH1 motif, conserved site
InterPro	IPR020726	Apoptosis regulator, Bcl-2, BH2 motif, conserved site
InterPro	IPR020728	Apoptosis regulator, Bcl-2, BH3 motif, conserved site
InterPro	IPR002475	Bcl2-like
InterPro	IPR026298	Blc2 family
Protein Ontology	PR:000002193	apoptosis regulator BAX

Graphical View of Protein Domain Structure

References

(Earliest) J:19076 Oltvai ZN, et al., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19
(Latest) J:210320 Josefsson EC, et al., Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways. Nat Commun. 2014;5:3455
All references(524)

Other accession IDs

MGD-MRK-16487