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Bax
Gene Detail
 Symbol
Name
ID
Bax
BCL2-associated X protein
MGI:99702
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.32 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr7:45461695-45466898 bp, - strand
From NCBI annotation of GRCm38

  5204 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: apoptosis regulator BAX
Gene Tree: Bax

Human
homologs
Human Homolog BAX, Bcl2-associated X protein
NCBI Gene ID 581
neXtProt AC  NX_Q07812
Human Synonyms  BCL2L4
Human Chr (Location)  19q13.3-q13.4; chr19:48954860-48961798 (+)  GRCh38
Alleles
and
phenotypes
All alleles(41) : Gene trapped(35) Targeted(6)
 
Homozygous null mutants display hyperplasia of thymocytes and B cells, reproductive failure with abnormal germ cells and gonadal morphology, and reduced cell death in the CNS and PNS. Female mutants exhibit a prolonged ovarian lifespan.
 
Gene Ontology
(GO)
classifications
All GO classifications: (215 annotations)
Process activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, ...
Component BAX complex, Bcl-2 family protein complex, ...
Function BH3 domain binding, BH domain binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (86 records)
Data Summary: Results (331)    Tissues (126)    Images (28)
Theiler Stages: 1, 2, 3, 4, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 93
Northern blot 49
Western blot 54
RT-PCR 124
RNase protection 5
cDNA source data(49)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(61) Genomic(2) cDNA(49) Primer pair(9) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000003873 (Evidence)
Entrez Gene12028 (Evidence)
UniGene19904
DFCITC1578578, TC1604578, TC1608700, TC1689860
DoTSDT.489903, DT.91445223
NIA Mouse Gene IndexU335981
PDB2XA0
Consensus CDS ProjectCCDS21246.1
International Mouse Knockout Project StatusBax
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12028 NCBI Gene Model | MGI Sequence Detail 5204 C57BL/6J ±  kb
transcript NM_007527 RefSeq | MGI Sequence Detail 869 C57BL/6 
polypeptide Q07813 UniProt | EBI | MGI Sequence Detail 192 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026304 Apoptosis regulator BAX
InterPro IPR020717 Apoptosis regulator, Bcl-2, BH1 motif, conserved site
InterPro IPR020726 Apoptosis regulator, Bcl-2, BH2 motif, conserved site
InterPro IPR020728 Apoptosis regulator, Bcl-2, BH3 motif, conserved site
InterPro IPR002475 Bcl2-like
InterPro IPR026298 Blc2 family
Protein Ontology PR:000002193 apoptosis regulator BAX
Graphical View of Protein Domain Structure
References (Earliest) J:19076 Oltvai ZN, et al., Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993 Aug 27;74(4):609-19
(Latest) J:210320 Josefsson EC, et al., Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways. Nat Commun. 2014;5:3455
All references(524)
Other
accession IDs
MGD-MRK-16487

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory