Adcy3
Gene Detail

Symbol Name ID

Adcy3 adenylate cyclase 3 MGI:99675

Synonyms

AC3, mKIAA0511

Feature Type

protein coding gene

Genetic Map

Chromosome 12

1.99 cM, cytoband A-B
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr12:4133103-4213525 bp, + strand From VEGA annotation of GRCm38   80423 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2978  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Adcy3

Human homologs

Human Homolog		ADCY3, adenylate cyclase 3
NCBI Gene ID		109
neXtProt AC		NX_O60266
Human Synonyms		AC3
Human Chr (Location)		2p23.3; chr2:25042038-25142055 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(5) Gene trapped(5)
 

Mice homozygous for one mutation of this gene display impaired olfaction and disorganization of glomeruli in the main olfactory bulb. Mutant animals also appear to be sterile as homozygous matings failed to produce litters. Mice with another mutant allele fail to survive beyond weaning.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	activation of adenylate cyclase activity, cAMP biosynthetic process, ...
Component	cilium, cytoplasm, ...
Function	adenylate cyclase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (27 records)
Data Summary: Results (472)    Tissues (186)    Images (65)
Theiler Stages: 22, 23, 24, 28

Assay Type	Results
RNA in situ	368
In situ reporter (knock in)	66
RT-PCR	38

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(10) Primer pair(2) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000033731 (Evidence)
Ensembl Gene Model	ENSMUSG00000020654 (Evidence)
Entrez Gene	104111 (Evidence)
EC	4.6.1.1
Consensus CDS Project	CCDS25787.1, CCDS49017.1
International Mouse Knockout Project Status	Adcy3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033731	VEGA Gene Model | MGI Sequence Detail	80423	C57BL/6J
transcript	OTTMUST00000084971	VEGA | MGI Sequence Detail	4672	Not Applicable
polypeptide	OTTMUSP00000045856	VEGA | MGI Sequence Detail	1145	Not Applicable

All sequences(50) RefSeq(6) UniProt(6)

Polymorphisms

SNPs(236 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001054	Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro	IPR018297	Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology	PR:000003754	adenylate cyclase type 3

References

(Earliest) J:22804 Edelhoff S, et al., Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse. Mamm Genome. 1995 Feb;6(2):111-3
(Latest) J:193573 Charles JF, et al., The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. Bone. 2012 Nov;51(5):902-12
All references(69)

Other accession IDs

MGD-MRK-16460