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Adcy3 Gene Detail
Summary
  • Symbol
    Adcy3
  • Name
    adenylate cyclase 3
  • Synonyms
    AC3, ACIII, mKIAA0511
  • Feature Type
    protein coding gene
  • IDs
    MGI:99675
    NCBI Gene: 104111
  • Gene Overview
    MyGene.info: ADCY3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:4133103-4213525 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 1.99 cM, cytoband A-B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    491 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99675
protein coding gene Chr12:4132996-4213525 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019564
protein coding gene Chr12:995833-1081138 (+)
A/J MGP_AJ_G0019531
protein coding gene Chr12:1017470-1099275 (+)
AKR/J MGP_AKRJ_G0019501
protein coding gene Chr12:1167787-1255700 (+)
BALB/cJ MGP_BALBcJ_G0019506
protein coding gene Chr12:1038988-1115991 (+)
C3H/HeJ MGP_C3HHeJ_G0019312
protein coding gene Chr12:954014-1043002 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019955
protein coding gene Chr12:1016411-1110830 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017580
protein coding gene Chr12:922463-1001300 (+)
CAST/EiJ MGP_CASTEiJ_G0018867
protein coding gene Chr12:1028127-1110118 (+)
CBA/J MGP_CBAJ_G0019283
protein coding gene Chr12:1268888-1381630 (+)
DBA/2J MGP_DBA2J_G0019396
protein coding gene Chr12:952958-1033150 (+)
FVB/NJ MGP_FVBNJ_G0019386
protein coding gene Chr12:978355-1057679 (+)
LP/J MGP_LPJ_G0019467
protein coding gene Chr12:1015527-1098417 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019420
protein coding gene Chr12:1082782-1165626 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019994
protein coding gene Chr12:948136-1037089 (+)
PWK/PhJ MGP_PWKPhJ_G0018633
protein coding gene Chr12:979323-1061426 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018424
protein coding gene Chr12:1022738-1103659 (+)
WSB/EiJ MGP_WSBEiJ_G0018919
protein coding gene Chr12:979399-1061992 (+)



Homology
more
  • Human Ortholog
    ADCY3, adenylate cyclase 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ADCY3, adenylate cyclase 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AC3, AC-III, BMIQ19
  • Links
    NCBI Gene ID: 109
    neXtProt AC: NX_O60266
    UniProt: O60266

  • Chr Location
    2p23.3; chr2:24819169-24920017 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 5 alleles in 6 genetic backgrounds
    10 phenotypes from multigenic genotypes
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one mutation of this gene display impaired olfaction and disorganization of glomeruli in the main olfactory bulb. Mutant animals also appear to be sterile as homozygous matings failed to produce litters. Mice with another mutant allele fail to survive beyond weaning.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020654 Ensembl Gene Model | MGI Sequence Detail 80423 C57BL/6J ±  kb
    transcript ENSMUST00000020984 Ensembl | MGI Sequence Detail 4348 Not Applicable  
    polypeptide ENSMUSP00000020984 Ensembl | MGI Sequence Detail 1145 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 11
      Primer pair 3
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16460
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 45
      Gene Ontology 12
      Phenotypes 34
    • Earliest
      J:22804 Edelhoff S, et al., Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse. Mamm Genome. 1995 Feb;6(2):111-3
    • Latest
      J:252905 Maurya DK, et al., Hedgehog signaling regulates ciliary localization of mouse odorant receptors. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):E9386-E9394

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory