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Adcy3
Gene Detail
Symbol

Name
ID
Adcy3
adenylate cyclase 3
MGI:99675
Synonyms
AC3, mKIAA0511
Feature Type
protein coding gene
Genetic Map
Chromosome 12
1.99 cM, cytoband A-B
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:4133103-4213525 bp, + strand
From VEGA annotation of GRCm38

  80423 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2978  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: adenylate cyclase
Gene Tree: Adcy3

Human
homologs
Human Homolog ADCY3, adenylate cyclase 3
NCBI Gene ID 109
neXtProt AC  NX_O60266
Human Synonyms  AC3
Human Chr (Location)  2p23.3; chr2:24819169-24919733 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Gene trapped(5) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one mutation of this gene display impaired olfaction and disorganization of glomeruli in the main olfactory bulb. Mutant animals also appear to be sterile as homozygous matings failed to produce litters. Mice with another mutant allele fail to survive beyond weaning.
 
Interactions
Adcy3 interacts with 107 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process activation of adenylate cyclase activity, cAMP biosynthetic process, ...
Component cilium, cytoplasm, ...
Function adenylate cyclase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (472)    Tissues (186)    Images (65)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 368
In situ reporter (knock in) 66
RT-PCR 38
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(10) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000033731 (Evidence)
Ensembl Gene ModelENSMUSG00000020654 (Evidence)
Entrez Gene104111 (Evidence)
EC4.6.1.1
Consensus CDS ProjectCCDS25787.1, CCDS49017.1
International Mouse Knockout Project StatusAdcy3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033731 VEGA Gene Model | MGI Sequence Detail 80423 C57BL/6J ±  kb
transcript OTTMUST00000084971 VEGA | MGI Sequence Detail 4672 Not Applicable 
polypeptide OTTMUSP00000045856 VEGA | MGI Sequence Detail 1145 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(14) UniProt(6)
Polymorphisms
SNPs within 2kb(492 from dbSNP Build 137)    SNPs within 2kb including multiple locations(494)
Protein-related
information
ResourceIDDescription
InterPro IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
InterPro IPR018297 Adenylyl cyclase class-3/4/guanylyl cyclase, conserved site
Protein Ontology PR:000003754 adenylate cyclase type 3
References
(Earliest) J:22804 Edelhoff S, et al., Mapping of adenylyl cyclase genes type I, II, III, IV, V, and VI in mouse. Mamm Genome. 1995 Feb;6(2):111-3
(Latest) J:205214 Dalton RP, et al., Co-opting the unfolded protein response to elicit olfactory receptor feedback. Cell. 2013 Oct 10;155(2):321-32
All references(79)
Other
accession IDs
MGD-MRK-16460

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory