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Adcy3tm1Drs
Targeted Allele Detail
Summary
Symbol: Adcy3tm1Drs
Name: adenylate cyclase 3; targeted mutation 1, Daniel R Storm
MGI ID: MGI:2661086
Synonyms: AC3-, AC3-M
Gene: Adcy3  Location: Chr12:4183397-4263525 bp, + strand  Genetic Position: Chr12, 1.99 cM, cytoband A-B
Alliance: Adcy3tm1Drs page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:64745
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe 5' portion of exon 1 was deleted and replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot analysis. (J:64745)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adcy3 Mutation:  42 strains or lines available
References
Original:  J:64745 Wong ST, et al., Disruption of the type III adenylyl cyclase gene leads to peripheral and behavioral anosmia in transgenic mice. Neuron. 2000 Sep;27(3):487-97
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory