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Piga
Gene Detail
Symbol

Name
ID
Piga
phosphatidylinositol glycan anchor biosynthesis, class A
MGI:99461
Synonyms
phosphatidylinositolglycan class A, Pig-a
Feature Type
protein coding gene
Genetic Map
Chromosome X
76.49 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
ChrX:164419793-164433916 bp, + strand
From VEGA annotation of GRCm38

  14124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1982  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIGA
Protein SuperFamily: GPI-anchor biosynthesis protein PIG-A
Gene Tree: Piga

Human
homologs
PIGA, phosphatidylinositol glycan anchor biosynthesis, class A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5277
neXtProt AC: NX_P37287

Human Synonyms: GPI3, MCAHS2, PIG-A, PNH1

Human Chr (Location): Xp22.1; chrX:15319451-15335554 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human PIGA

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations produce lethal neural tube defects. Specific allele combinations are viable but oocytes are defective.
 
Phenotype Images(1)
Interactions
Piga interacts with 301 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase piga ; ZFIN piga    NEW 
Molecular
reagents
All nucleic(23) Genomic(9) cDNA(14)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000019508 (Evidence)
Ensembl Gene Model ENSMUSG00000031381 (Evidence)
Entrez Gene 18700 (Evidence)
DFCI TC1581120, TC1617229, TC1645755, TC1714532
DoTS DT.101374987, DT.101374988, DT.40172570, DT.91565703, DT.94140610
Consensus CDS Project CCDS30522.1
International Mouse Phenotyping Consortium Status Piga
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019508 VEGA Gene Model | MGI Sequence Detail 14124 C57BL/6J ±  kb
transcript OTTMUST00000046590 VEGA | MGI Sequence Detail 3597 Not Applicable 
polypeptide OTTMUSP00000021039 VEGA | MGI Sequence Detail 485 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(6) UniProt(9)
Polymorphisms
RFLP(2) : SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001296 Glycosyl transferase, family 1
InterPro IPR013234 PIGA, GPI anchor biosynthesis
Protein Ontology PR:000027008 N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein
References
(Earliest) J:26642 Takeda J, et al., Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell. 1993 May 21;73(4):703-11
(Latest) J:178391 Hazenbos WL, et al., Impaired FcepsilonRI stability, signaling, and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins. Blood. 2011 Oct 20;118(16):4377-83
All references(59)
Other
accession IDs
MGD-MRK-16231, MGI:2147852

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory