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Piga
Gene Detail
 Symbol
Name
ID
Piga
phosphatidylinositol glycan anchor biosynthesis, class A
MGI:99461
Synonyms phosphatidylinositolglycan class A, Pig-a
Feature Type protein coding gene
Genetic Map
Chromosome X
76.49 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
ChrX:164419793-164433916 bp, + strand
From VEGA annotation of GRCm38

  14124 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1982  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: GPI-anchor biosynthesis protein PIG-A
Gene Tree: Piga

Human
homologs
Human Homolog PIGA, phosphatidylinositol glycan anchor biosynthesis, class A
NCBI Gene ID 5277
neXtProt AC  NX_P37287
Human Synonyms  GPI3, MCAHS2, PIG-A
Human Chr (Location)  Xp22.1; chrX:15319451-15335554 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human PIGA
Alleles
and
phenotypes
All alleles(6) : Targeted(4) Gene trapped(2)
 
Mutations produce lethal neural tube defects. Specific allele combinations are viable but oocytes are defective.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process biosynthetic process, GPI anchor biosynthetic process
Component endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function transferase activity, transferase activity, transferring glycosyl groups
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) Genomic(9) cDNA(14)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000019508 (Evidence)
Ensembl Gene ModelENSMUSG00000031381 (Evidence)
Entrez Gene18700 (Evidence)
DFCITC1581120, TC1617229, TC1645755, TC1714532
DoTSDT.101374987, DT.101374988, DT.40172570, DT.91565703, DT.94140610
Consensus CDS ProjectCCDS30522.1
International Mouse Knockout Project StatusPiga
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019508 VEGA Gene Model | MGI Sequence Detail 14124 C57BL/6J ±  kb
transcript OTTMUST00000046585 VEGA | MGI Sequence Detail 3583 Not Applicable 
polypeptide OTTMUSP00000021037 VEGA | MGI Sequence Detail 485 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(4) UniProt(9)
Polymorphisms RFLP(2) : SNPs within 2kb(108 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001296 Glycosyl transferase, family 1
InterPro IPR013234 PIGA, GPI anchor biosynthesis
Protein Ontology PR:000027008 N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein
References (Earliest) J:26642 Takeda J, et al., Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell. 1993 May 21;73(4):703-11
(Latest) J:178391 Hazenbos WL, et al., Impaired FcepsilonRI stability, signaling, and effector functions in murine mast cells lacking glycosylphosphatidylinositol-anchored proteins. Blood. 2011 Oct 20;118(16):4377-83
All references(60)
Other
accession IDs
MGD-MRK-16231, MGI:2147852

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory