Piga
Gene Detail

Symbol Name ID

Piga phosphatidylinositol glycan anchor biosynthesis, class A MGI:99461

Synonyms

phosphatidylinositolglycan class A, Pig-a

Feature Type

protein coding gene

Genetic Map

Chromosome X

76.49 cM, cytoband F3-F4
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

ChrX:164419793-164433916 bp, + strand From VEGA annotation of GRCm38   14124 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1982  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: GPI-anchor biosynthesis protein PIG-A
Gene Tree: Piga

Human homologs

Human Homolog		PIGA, phosphatidylinositol glycan anchor biosynthesis, class A
NCBI Gene ID		5277
neXtProt AC		NX_P37287
Human Synonyms		GPI3, MCAHS2, PIG-A
Human Chr (Location)		Xp22.1; chrX:15337573-15353676 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PIGA

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Mutations produce lethal neural tube defects. Specific allele combinations are viable but oocytes are defective.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	biosynthetic process, GPI anchor biosynthetic process
Component	endoplasmic reticulum, endoplasmic reticulum membrane, ...
Function	transferase activity, transferase activity, transferring glycosyl groups

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)   
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) Genomic(9) cDNA(14)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000019508 (Evidence)
Ensembl Gene Model	ENSMUSG00000031381 (Evidence)
Entrez Gene	18700 (Evidence)
DFCI	TC1581120, TC1617229, TC1645755, TC1714532
DoTS	DT.101374987, DT.101374988, DT.40172570, DT.91565703, DT.94140610
Consensus CDS Project	CCDS30522.1
International Mouse Knockout Project Status	Piga

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019508	VEGA Gene Model | MGI Sequence Detail	14124	C57BL/6J
transcript	OTTMUST00000046585	VEGA | MGI Sequence Detail	3583	Not Applicable
polypeptide	OTTMUSP00000021037	VEGA | MGI Sequence Detail	485	Not Applicable

All sequences(59) RefSeq(2) UniProt(9)

Polymorphisms

RFLP(2) : SNPs(95 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001296	Glycosyl transferase, family 1
InterPro	IPR013234	PIGA, GPI anchor biosynthesis
Protein Ontology	PR:000027008	N-acetylglucosaminyl-phosphatidylinositol biosynthetic protein

References

(Earliest) J:26642 Takeda J, et al., Deficiency of the GPI anchor caused by a somatic mutation of the PIG-A gene in paroxysmal nocturnal hemoglobinuria. Cell. 1993 May 21;73(4):703-11
(Latest) J:181221 Murakami H, et al., Enhanced response of T lymphocytes from Pgap3 knockout mouse: Insight into roles of fatty acid remodeling of GPI anchored proteins. Biochem Biophys Res Commun. 2012 Jan 27;417(4):1235-41
All references(61)

Other accession IDs

MGD-MRK-16231, MGI:2147852