Symbol
Name
ID

Piga
phosphatidylinositol glycan anchor biosynthesis, class A
MGI:99461

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Abnormal erythrocyte enzyme concentration or activity

Decreased circulating iron concentration

Unconjugated hyperbilirubinemia

Increased blood urea nitrogen

Reduced haptoglobin level

Increased circulating lactate dehydrogenase concentration

Elevated circulating alkaline phosphatase concentration

Renal Fanconi syndrome

Hydrops fetalis

Elevated hepatic iron concentration

Microvesicular hepatic steatosis

Glycosuria

Proteinuria

Hemoglobinuria

Paroxysmal nocturnal hemoglobinuria

Hemosiderinuria

Disease(s) Associated with PIGA

multiple congenital anomalies-hypotonia-seizures syndrome 2

paroxysmal nocturnal hemoglobinuria

Mouse Phenotypes		abnormal amino acid level	dehydration	impaired skin barrier function
Availability	Mouse Genotype	abnormal amino acid level	dehydration	impaired skin barrier function
	Piga^tm1Tak/Piga^tm1Tak Tg(KRT5-cre)1Tak/0 (conditional)
	Piga^tm1Tak/Y Tg(KRT5-cre)1Tak/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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