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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Piga
phosphatidylinositol glycan anchor biosynthesis, class A
MGI:99461
43 phenotypes from 4 alleles in 7 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Pigatm1Tak/Y
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J 		abnormal craniofacial bone morphology J:277316
cleft palate J:277316
cleft upper lip J:277316
Pigatm1.1Tak/Y
involves: 129S1/Sv * 129X1/SvJ 		abnormal visceral yolk sac morphology J:53967
decreased embryo size J:53967
prenatal lethality, complete penetrance J:53967
Pigatm1.1Tak/Piga+
involves: 129S1/Sv * 129X1/SvJ 		abnormal brain development J:53967
abnormal cartilage development J:53967
abnormal craniofacial bone morphology J:53967
normal craniofacial phenotype J:53967
exencephaly J:53967
prenatal lethality, complete penetrance J:53967
Pigatm1Bsl/Piga+
Tg(EIIa-cre)C5379Lmgd/0
involves: 129S1/Sv * FVB/NJ 		abnormal definitive hematopoiesis J:75506
abnormal erythrocyte morphology J:75506
abnormal erythrocyte physiology J:75506
abnormal facial morphology J:56055
abnormal suckling behavior J:56055
cleft palate J:56055
increased erythrocyte osmotic fragility J:75506
perinatal lethality, incomplete penetrance J:75506
reticulocytosis J:75506
Pigatm1Bsl/Piga+
Tg(FES-cre)31Bsl/0
involves: 129S1/Sv * C57BL/6 * CBA/Ca 		decreased locomotor activity J:71354
increased B cell derived lymphoma incidence J:71354
increased hemangioma incidence J:71354
weakness J:71354
weight loss J:71354
Pigatm1Bsl/Y
Tg(FES-cre)31Bsl/0
involves: 129S1/Sv * C57BL/6 * CBA/Ca 		abnormal gait J:71354
decreased locomotor activity J:71354
increased B cell derived lymphoma incidence J:71354
increased hemangioma incidence J:71354
weakness J:71354
weight loss J:71354
Pigatm1Tak/Piga+
Tg(KRT5-cre)1Tak/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 		acanthosis J:41746
scaly skin J:41746
Pigatm1Tak/Pigatm1Tak
Tg(FES-cre)31Bsl/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA/Ca 		abnormal T cell activation J:162065
abnormal T cell morphology J:162065
abnormal T cell physiology J:162065
decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number J:162065
Pigatm1Tak/Pigatm1Tak
Tg(KRT5-cre)1Tak/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 		abnormal amino acid level J:91794
abnormal epidermal lamellar body morphology J:91794
abnormal epidermis stratum corneum morphology J:91794
dehydration J:91794
impaired skin barrier function J:91794
Pigatm1Tak/Pigatm1Tak
Tg(Zp3-cre)1Gwh/0
involves: 129S1/Sv * 129X1/SvJ 		abnormal gametes J:83792
failure of sperm-egg fusion J:83792
female infertility J:83792
impaired fertilization J:83792
Pigatm1Tak/Y
Tg(KRT5-cre)1Tak/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 		abnormal amino acid level J:91794
abnormal epidermal lamellar body morphology J:91794
abnormal epidermis stratum corneum morphology J:41746, J:91794
dehydration J:91794
hyperkeratosis J:41746
impaired skin barrier function J:91794
postnatal lethality, complete penetrance J:41746
scaly skin J:41746
wrinkled skin J:41746
Pigatm2Tak/Y
chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal plasma membrane morphology J:32798
prenatal lethality, complete penetrance J:32798
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory