Piga^tm2Tak
Targeted Allele Detail

Summary

• Symbol: Piga^tm2Tak
• Name: phosphatidylinositol glycan anchor biosynthesis, class A; targeted mutation 2, Junji Takeda
• MGI ID: MGI:3652879
• Gene: Piga Location: ChrX:163202814-163216912 bp, + strand Genetic Position: ChrX, 76.49 cM, cytoband F3-F4
• Alliance: Piga^tm2Tak page

Mutation origin

• Mouse Generated: Earliest citation of chimera generation: J:32798
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A targeting vector was used to replace exon 2 with a PGK-neo. (J:32798)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Piga Mutation: 4 strains or lines available

Notes

Mice are only studied as chimeras since the targeted mutation of this X-linked marker was accomplished in male ES cells and no viable mouse line can be established.

References

• Original: J:32798 Kawagoe K, et al., Glycosylphosphatidylinositol-anchor-deficient mice: implications for clonal dominance of mutant cells in paroxysmal nocturnal hemoglobinuria. Blood. 1996 May 1;87(9):3600-6
• All: 2 reference(s)