Phenotypes associated with this allele

• Allele Symbol: Piga^tm2Tak
• Allele Name: targeted mutation 2, Junji Takeda
• Allele ID: MGI:3652879
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Piga^tm2Tak/Y	chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3814055

Genotype
MGI:3814055

ot1

• Allelic Composition: Piga^tm2Tak/Y
• Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:32798 )

♂ • mice displaying a high level of chimerism for cells derived from injected or aggregated ES cells with this targeted allele die during development

cellular

abnormal plasma membrane morphology ( J:32798 )

♂ • this phenotype can only be studied in chimeric mice

♂ • glycosyl phosphatidyl inositol (GPI) anchors are absent in some erythrocytes and B lymphocytes in mice with a low level of chimerism

♂ • a higher incidence of CD4+ and CD8+ cells that are also GPI-

♂ • the number of GPI- erythrocytes may increase in mice that are greater than 12 months of age