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Yy1 Gene Detail
Summary
  • Symbol
    Yy1
  • Name
    YY1 transcription factor
  • Synonyms
    delta transcription factor, NF-E1, UCRBP transcription factor, Yin Yang 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99150
    NCBI Gene: 22632
  • Gene Overview
    MyGene.info: YY1
Location & Maps
more
  • Sequence Map
    Chr12:108792973-108816632 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      23660 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 59.58 cM
  • Mapping Data
    7 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    YY1, YY1 transcription factor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    YY1, YY1 transcription factor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1
  • Links
    NCBI Gene ID: 7528
    neXtProt AC: NX_P25490

  • Chr Location
    14q; chr14:100238765-100279034 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 4 alleles in 4 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Gene trapped
    13
  • Targeted
    6
  • Incidental Mutations
Homozygous null mice die in utero shortly after implantation. Incomplete penetrance of embryonic growth retardation and exencephaly are observed in haploinsufficient mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017257 VEGA Gene Model | MGI Sequence Detail 23660 C57BL/6J ±  kb
transcript OTTMUST00000041760 VEGA | MGI Sequence Detail 2662 Not Applicable  
polypeptide OTTMUSP00000018770 VEGA | MGI Sequence Detail 414 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    109 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017553 transcriptional repressor protein YY1
  • InterPro Domains
    IPR017114 Transcription factor yin/yang
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 23
    Genomic 7
    cDNA 11
    Primer pair 4
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-15848, MGI:2145026
References
more
  • Summaries
    All 114
    Developmental Gene Expression 22
    Gene Ontology 19
    Phenotypes 34
  • Earliest
    J:13111 Safrany G, et al., Characterization of the mouse gene that encodes the delta/YY1/NF-E1/UCRBP transcription factor. Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5559-63
  • Latest
    J:229171 Beketaev I, et al., cis-regulatory control of Mesp1 expression by YY1 and SP1 during mouse embryogenesis. Dev Dyn. 2016 Mar;245(3):379-87

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory