Xbp1 MGI Mouse Gene Detail - MGI:98970 - X-box binding protein 1

Symbol

Xbp1
Name

X-box binding protein 1
Synonyms

D11Ertd39e, TREB-5, TREB5, XBP-1

Feature Type

protein coding gene
IDs

MGI:98970
NCBI Gene: 22433
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr11:5470659-5475893 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 3.61 cM
Mapping Data

3 experiments

SNPs within 2kb

177 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98970	protein coding gene	Chr11:5470641-5475993 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018001	protein coding gene	Chr11:2581606-2589210 (+)
A/J	MGP_AJ_G0017974	protein coding gene	Chr11:2489640-2494876 (+)
AKR/J	MGP_AKRJ_G0017938	protein coding gene	Chr11:2623456-2628692 (+)
BALB/cJ	MGP_BALBcJ_G0017942	protein coding gene	Chr11:2478876-2484688 (+)
C3H/HeJ	MGP_C3HHeJ_G0017755	protein coding gene	Chr11:2495669-2500935 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018394	protein coding gene	Chr11:2652542-2657804 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016052	protein coding gene	Chr11:2381004-2386192 (+)
CAST/EiJ	MGP_CASTEiJ_G0017317	protein coding gene	Chr11:2451924-2461861 (+)
CBA/J	MGP_CBAJ_G0017730	protein coding gene	Chr11:2975968-2982741 (+)
DBA/2J	MGP_DBA2J_G0017840	protein coding gene	Chr11:2388014-2393463 (+)
FVB/NJ	MGP_FVBNJ_G0017832	protein coding gene	Chr11:2429544-2434804 (+)
LP/J	MGP_LPJ_G0017911	protein coding gene	Chr11:2658152-2663427 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017858	protein coding gene	Chr11:2608992-2615438 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018434	protein coding gene	Chr11:2606083-2611575 (+)
PWK/PhJ	MGP_PWKPhJ_G0017097	protein coding gene	Chr11:2412744-2425778 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016894	protein coding gene	Chr11:2596670-2601935 (+)
WSB/EiJ	MGP_WSBEiJ_G0017371	protein coding gene	Chr11:2466091-2472014 (+)

Human Ortholog

XBP1, X-box binding protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

XBP1, X-box binding protein 1
Synonyms

TREB-5, TREB5, XBP-1, XBP2
Links

HGNC:12801

NCBI Gene ID: 7494

UniProt: P17861
Chr Location

22q12.1; chr22:28794555-28800597 (-) GRCh38

MGI Vertebrate Homology

Xbp1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: XBP1
Gene Tree

Xbp1

Diseases

1 with Xbp1 mouse models

Human Disease

Mouse Models

inflammatory bowel disease

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

83 phenotypes from 10 alleles in 14 genetic backgrounds
23 phenotypes from multigenic genotypes
168 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

29
Endonuclease-mediated

5
Gene trapped

7
Targeted

16
Transgenic

1
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants exhibit markedly impaired liver development resulting in severe anemia, necrosis of cardiac myocytes, morphological abnormalities of the neural tube, and fetal death around embryonic day 14.

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All GO Annotations

218
GO References

28

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1120
Tissues

199
cDNA Data

641
Literature Summary

87

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase xbp1

ZFIN xbp1

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All Sequences

80
RefSeq

4
UniProt

5
CCDS

CCDS24400.1

Ensembl

ENSMUSG00000020484 (Evidence)
NCBI Gene

22433

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020484	Ensembl Gene Model \| MGI Sequence Detail	5235	C57BL/6J	± kb
transcript	ENSMUST00000239150	Ensembl \| MGI Sequence Detail	1116	Not Applicable
polypeptide	ENSMUSP00000158915	Ensembl \| MGI Sequence Detail	371	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017476 X-box-binding protein 1

(term hierarchy)
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily

IPR052470 Endoplasmic Reticulum Stress-Regulated Transcription Factor
GlyGen

O35426 1 site, 1 O-linked glycan (1 site)

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All nucleic 676

cDNA 642

Primer pair 29

Other 5

Microarray probesets 6

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MGD-MRK-15468, MGI:1098709

Summaries

All 372

Developmental Gene Expression 87

Diseases 1

Gene Ontology 28

Phenotypes 168
Earliest

J:14524 Clauss IM, et al., In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn. 1993 Jun;197(2):146-56
Latest

J:364497 Zhao T, et al., GPAT4 sustains endoplasmic reticulum homeostasis in endocardial cells and safeguards heart development. Nat Commun. 2025 Apr 8;16(1):3345

TSS for Xbp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr100178	Chr11:5470652-5470656 (+)	-5 bp
Tssr100179	Chr11:5470951-5470966 (+)	300 bp
Tssr100180	Chr11:5470970-5470989 (+)	321 bp
Tssr100181	Chr11:5474789-5474804 (+)	4,138 bp
Tssr100182	Chr11:5475191-5475204 (+)	4,539 bp
Tssr100183	Chr11:5475255-5475275 (+)	4,606 bp
Tssr100184	Chr11:5475474-5475486 (+)	4,821 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24