Xbp1 MGI Mouse Gene Detail - MGI:98970 - X-box binding protein 1

Xbp1 Gene Detail

Symbol

Xbp1
Name

X-box binding protein 1
Synonyms

D11Ertd39e, TREB5, TREB-5, XBP-1

Feature Type

protein coding gene
IDs

MGI:98970
NCBI Gene: 22433
Gene Overview

MyGene.info: XBP1

Sequence Map

Chr11:5520659-5525893 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

5235 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 3.61 cM
Mapping Data

3 experiments

Human Ortholog

XBP1, X-box binding protein 1

Vertebrate Orthologs

5

Human Ortholog

XBP1, X-box binding protein 1
Orthology source: HomoloGene, HGNC
Synonyms

TREB5, TREB-5, XBP-1, XBP2
Links

HGNC:12801

NCBI Gene ID: 7494

neXtProt AC: NX_P17861
Chr Location

22q12.1; chr22:28794560-28800572 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 3722
1 human;1 mouse;1 rat;1 cattle;1 dog
HCOP

human homology predictions: XBP1
Protein SuperFamily

X box-binding protein 1
Gene Tree

Xbp1

Diseases

1 with human XBP1 associations

				Human Disease	Mouse Models
				Major Affective Disorder 7; MAFD7 OMIM: 612371

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

59 phenotypes from 8 alleles in 12 genetic backgrounds
9 phenotypes from multigenic genotypes
66 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Gene trapped

7
Targeted

14

Homozygous mutants exhibit markedly impaired liver development resulting in severe anemia, necrosis of cardiac myocytes, morphological abnormalities of the neural tube, and fetal death around embryonic day 14.

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All GO Annotations

73
GO References

18

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

239
Tissues

115
cDNA Data

639
Literature Summary

41

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase xbp1

ZFIN xbp1

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Xbp1 interacts with 177 markers (Mir1b, Mir10b, Mir19a, ...) View All

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All Sequences

67
RefSeq

4
UniProt

4
CCDS

CCDS24400.1
UniGene

469937

			Length	Strain/Species	Flank
genomic	OTTMUSG00000006338	VEGA Gene Model \| MGI Sequence Detail	5235	C57BL/6J	± kb
transcript	OTTMUST00000014402	VEGA \| MGI Sequence Detail	2129	Not Applicable
polypeptide	OTTMUSP00000006681	VEGA \| MGI Sequence Detail	267	Not Applicable

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SNPs within 2kb

15 from dbSNP Build 142

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UniProt

4 Sequences
Protein Ontology

PR:000017476 X-box-binding protein 1
InterPro Domains

IPR004827 Basic-leucine zipper domain

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All nucleic 657

cDNA 640

Primer pair 15

Other 2

Microarray probesets 6

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MGD-MRK-15468, MGI:1098709

Summaries

All 164

Developmental Gene Expression 41

Gene Ontology 18

Phenotypes 66
Earliest

J:14524 Clauss IM, et al., In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn. 1993 Jun;197(2):146-56
Latest

J:233630 Davis KR, et al., XBP1 Regulates the Biosynthetic Capacity of the Mammary Gland During Lactation by Controlling Epithelial Expansion and Endoplasmic Reticulum Formation. Endocrinology. 2016 Jan;157(1):417-28

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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