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Xbp1
Gene Detail
Symbol

Name
ID
Xbp1
X-box binding protein 1
MGI:98970
Synonyms
D11Ertd39e, TREB5, TREB-5, XBP-1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
3.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:5520659-5525893 bp, + strand
From VEGA annotation of GRCm38

  5235 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3722  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

HCOP human homology predictions: XBP1
Protein SuperFamily: X box-binding protein 1
Gene Tree: Xbp1

Human
homologs
XBP1, X-box binding protein 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7494
neXtProt AC: NX_P17861

Human Synonyms: TREB5, TREB-5, XBP-1, XBP2

Human Chr (Location): 22q12.1; chr22:28794560-28800572 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human XBP1

Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(7) Targeted(14)
 
Homozygous mutants exhibit markedly impaired liver development resulting in severe anemia, necrosis of cardiac myocytes, morphological abnormalities of the neural tube, and fetal death around embryonic day 14.
 
Interactions
Xbp1 interacts with 177 markers (Mir1b, Mir10b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (122 annotations)
Process adipose tissue development, angiogenesis, ...
Component cell, cytoplasm, ...
Function chromatin DNA binding, core promoter binding, ...
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (216)    Tissues (109)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RNA in situ 116
Western blot 11
RT-PCR 78
cDNA source data(639)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase xbp1 ; ZFIN xbp1    NEW 
Molecular
reagents
All nucleic(656) cDNA(640) Primer pair(14) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000006338 (Evidence)
Ensembl Gene Model ENSMUSG00000020484 (Evidence)
Entrez Gene 22433 (Evidence)
UniGene 469937
DFCI TC1573995, TC1581376, TC1626706, TC1664431, TC1675223, TC1736635, TC1746839
DoTS DT.101206153, DT.101305889, DT.110546222, DT.110546241, DT.87069884, DT.91345467, DT.94138632, DT.94138659, DT.97354287, DT.97355298
NIA Mouse Gene Index U012281
Consensus CDS Project CCDS24400.1
International Mouse Phenotyping Consortium Status Xbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006338 VEGA Gene Model | MGI Sequence Detail 5235 C57BL/6J ±  kb
transcript OTTMUST00000014402 VEGA | MGI Sequence Detail 2129 Not Applicable 
polypeptide OTTMUSP00000006681 VEGA | MGI Sequence Detail 267 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
Protein Ontology PR:000017476 X-box-binding protein 1
References
(Earliest) J:14524 Clauss IM, et al., In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn. 1993 Jun;197(2):146-56
(Latest) J:213560 Le Pape S, et al., Polynomial algebra reveals diverging roles of the unfolded protein response in endothelial cells during ischemia-reperfusion injury. FEBS Lett. 2014 Aug 25;588(17):3062-7
All references(154)
Other
accession IDs
MGD-MRK-15468, MGI:1098709

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory