About   Help   FAQ
Xbp1
Gene Detail
 Symbol
Name
ID
Xbp1
X-box binding protein 1
MGI:98970
Synonyms D11Ertd39e, TREB5, TREB-5, XBP-1
Feature Type protein coding gene
Genetic Map
Chromosome 11
3.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:5520659-5525893 bp, + strand
From VEGA annotation of GRCm38

  5235 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3722  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

Protein SuperFamily: X box-binding protein 1
Gene Tree: Xbp1

Human
homologs
Human Homolog XBP1, X-box binding protein 1
NCBI Gene ID 7494
neXtProt AC  NX_P17861
Human Synonyms  TREB5, XBP-1, XBP2
Human Chr (Location)  22q12.1; chr22:28794560-28800572 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human XBP1
Mutations,
alleles, and
phenotypes
All mutations/alleles(21) : Gene trapped(7) Targeted(14)
 
Homozygous mutants exhibit markedly impaired liver development resulting in severe anemia, necrosis of cardiac myocytes, morphological abnormalities of the neural tube, and fetal death around embryonic day 14.
 
Interactions
Xbp1 interacts with 177 markers (Mir1b, Mir10b, Mir19a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process endoplasmic reticulum unfolded protein response, epithelial cell maturation, ...
Component nucleus
Function DNA binding, RNA polymerase II transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (216)    Tissues (102)    Images (45)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 11
RNA in situ 116
Western blot 11
RT-PCR 78
cDNA source data(639)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(656) cDNA(640) Primer pair(14) Other(2)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000006338 (Evidence)
Ensembl Gene ModelENSMUSG00000020484 (Evidence)
Entrez Gene22433 (Evidence)
UniGene469937
DFCITC1573995, TC1581376, TC1626706, TC1664431, TC1675223, TC1736635, TC1746839
DoTSDT.101206153, DT.101305889, DT.110546222, DT.110546241, DT.87069884, DT.91345467, DT.94138632, DT.94138659, DT.97354287, DT.97355298
NIA Mouse Gene IndexU012281
Consensus CDS ProjectCCDS24400.1
International Mouse Knockout Project StatusXbp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006338 VEGA Gene Model | MGI Sequence Detail 5235 C57BL/6J ±  kb
transcript OTTMUST00000014402 VEGA | MGI Sequence Detail 2129 Not Applicable 
polypeptide OTTMUSP00000006681 VEGA | MGI Sequence Detail 267 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(4) UniProt(4)
Polymorphisms SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
Protein Ontology PR:000017476 X-box-binding protein 1
References (Earliest) J:14524 Clauss IM, et al., In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn. 1993 Jun;197(2):146-56
(Latest) J:210646 Eletto D, et al., Protein disulfide isomerase A6 controls the decay of IRE1alpha signaling via disulfide-dependent association. Mol Cell. 2014 Feb 20;53(4):562-76
All references(132)
Other
accession IDs
MGD-MRK-15468, MGI:1098709

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory