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Xbp1 Gene Detail
Summary
  • Symbol
    Xbp1
  • Name
    X-box binding protein 1
  • Synonyms
    D11Ertd39e, TREB5, TREB-5, XBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98970
    NCBI Gene: 22433
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:5470659-5475893 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 11, 3.61 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    15 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98970
protein coding gene Chr11:5470641-5475993 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018001
protein coding gene Chr11:2581606-2589210 (+)
A/J MGP_AJ_G0017974
protein coding gene Chr11:2489640-2494876 (+)
AKR/J MGP_AKRJ_G0017938
protein coding gene Chr11:2623456-2628692 (+)
BALB/cJ MGP_BALBcJ_G0017942
protein coding gene Chr11:2478876-2484688 (+)
C3H/HeJ MGP_C3HHeJ_G0017755
protein coding gene Chr11:2495669-2500935 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018394
protein coding gene Chr11:2652542-2657804 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016052
protein coding gene Chr11:2381004-2386192 (+)
CAST/EiJ MGP_CASTEiJ_G0017317
protein coding gene Chr11:2451924-2461861 (+)
CBA/J MGP_CBAJ_G0017730
protein coding gene Chr11:2975968-2982741 (+)
DBA/2J MGP_DBA2J_G0017840
protein coding gene Chr11:2388014-2393463 (+)
FVB/NJ MGP_FVBNJ_G0017832
protein coding gene Chr11:2429544-2434804 (+)
LP/J MGP_LPJ_G0017911
protein coding gene Chr11:2658152-2663427 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017858
protein coding gene Chr11:2608992-2615438 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018434
protein coding gene Chr11:2606083-2611575 (+)
PWK/PhJ MGP_PWKPhJ_G0017097
protein coding gene Chr11:2412744-2425778 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016894
protein coding gene Chr11:2596670-2601935 (+)
WSB/EiJ MGP_WSBEiJ_G0017371
protein coding gene Chr11:2466091-2472014 (+)



Homology
more
  • Human Ortholog
    XBP1, X-box binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    XBP1, X-box binding protein 1
  • Synonyms
    TREB5, TREB-5, XBP-1, XBP2
  • Links
    NCBI Gene ID: 7494
    neXtProt AC: NX_P17861
    UniProt: P17861

  • Chr Location
    22q12.1; chr22:28794555-28800597 (-)  GRCh38

Human Diseases
more
  • Diseases
    1 with Xbp1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    71 phenotypes from 9 alleles in 13 genetic backgrounds
    34 phenotypes from multigenic genotypes
    154 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants exhibit markedly impaired liver development resulting in severe anemia, necrosis of cardiac myocytes, morphological abnormalities of the neural tube, and fetal death around embryonic day 14.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020484 Ensembl Gene Model | MGI Sequence Detail 5235 C57BL/6J ±  kb
    transcript ENSMUST00000239150 Ensembl | MGI Sequence Detail 1116 Not Applicable  
    polypeptide ENSMUSP00000158915 Ensembl | MGI Sequence Detail 371 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 672
      cDNA 642
      Primer pair 25
      Other 5

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15468, MGI:1098709
    References
    more
    • Summaries
      All 344
      Developmental Gene Expression 81
      Diseases 1
      Gene Ontology 23
      Phenotypes 154
    • Earliest
      J:14524 Clauss IM, et al., In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn. 1993 Jun;197(2):146-56
    • Latest
      J:344311 Yan W, et al., Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy. Commun Biol. 2024 Jan 13;7(1):94

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory