Xbp1
Gene Detail

Symbol Name ID

Xbp1 X-box binding protein 1 MGI:98970

Synonyms

D11Ertd39e, TREB5, TREB-5, XBP-1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

3.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:5520659-5525893 bp, + strand From VEGA annotation of GRCm38   5235 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3722  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

Protein SuperFamily: X box-binding protein 1
Gene Tree: Xbp1

Human homologs

Human Homolog		XBP1, X-box binding protein 1
NCBI Gene ID		7494
neXtProt AC		NX_P17861
Human Synonyms		TREB5, XBP-1, XBP2
Human Chr (Location)		22q12.1; chr22:28794560-28800572 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human XBP1

Mutations, alleles, and phenotypes

All mutations/alleles(19) : Gene trapped(7) Targeted(12)
 

Homozygous mutants exhibit markedly impaired liver development resulting in severe anemia, necrosis of cardiac myocytes, morphological abnormalities of the neural tube, and fetal death around embryonic day 14.

 

Interactions

Xbp1 interacts with 177 markers (Mir1b, Mir10b, Mir19a, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	endoplasmic reticulum unfolded protein response, epithelial cell maturation, ...
Component	nucleus
Function	DNA binding, RNA polymerase II transcription factor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (33 records)

Data Summary: Results (227)    Tissues (107)    Images (45)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	11
RNA in situ	116
Western blot	11
RT-PCR	89

cDNA source data(639)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(656) cDNA(640) Primer pair(14) Other(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000006338 (Evidence)
Ensembl Gene Model	ENSMUSG00000020484 (Evidence)
Entrez Gene	22433 (Evidence)
UniGene	469937
DFCI	TC1573995, TC1581376, TC1626706, TC1664431, TC1675223, TC1736635, TC1746839
DoTS	DT.101206153, DT.101305889, DT.110546222, DT.110546241, DT.87069884, DT.91345467, DT.94138632, DT.94138659, DT.97354287, DT.97355298
NIA Mouse Gene Index	U012281
Consensus CDS Project	CCDS24400.1
International Mouse Knockout Project Status	Xbp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006338	VEGA Gene Model | MGI Sequence Detail	5235	C57BL/6J
transcript	OTTMUST00000014402	VEGA | MGI Sequence Detail	2129	Not Applicable
polypeptide	OTTMUSP00000006681	VEGA | MGI Sequence Detail	267	Not Applicable

All sequences(84) RefSeq(4) UniProt(4)

Polymorphisms

SNPs within 2kb(15 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
Protein Ontology	PR:000017476	X-box-binding protein 1

References

(Earliest) J:14524 Clauss IM, et al., In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn. 1993 Jun;197(2):146-56
(Latest) J:210646 Eletto D, et al., Protein disulfide isomerase A6 controls the decay of IRE1alpha signaling via disulfide-dependent association. Mol Cell. 2014 Feb 20;53(4):562-76
All references(131)

Other accession IDs

MGD-MRK-15468, MGI:1098709