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Xbp1 Gene Detail
Summary
  • Symbol
    Xbp1
  • Name
    X-box binding protein 1
  • Synonyms
    D11Ertd39e, TREB5, TREB-5, XBP-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98970
    NCBI Gene: 22433
  • Gene Overview
    MyGene.info: XBP1
Location & Maps
more
  • Genetic Map
    Chromosome 11, 3.61 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
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  • Human Ortholog
    XBP1, X-box binding protein 1
  • Vertebrate Orthologs
    5
  • Human Ortholog
    XBP1, X-box binding protein 1
    Orthology source: HomoloGene
  • Synonyms
    TREB5, TREB-5, XBP-1, XBP2
  • Links
    NCBI Gene ID: 7494
    neXtProt AC: NX_P17861

  • Chr Location
    22q12.1; chr22:28794560-28800572 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human XBP1 associations

Human Disease Mouse Models
       Major Affective Disorder 7; MAFD7   OMIM: 612371
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    68 phenotypes from 8 alleles in 13 genetic backgrounds
    9 phenotypes from multigenic genotypes
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Gene trapped
    7
  • Targeted
    14
Homozygous mutants exhibit markedly impaired liver development resulting in severe anemia, necrosis of cardiac myocytes, morphological abnormalities of the neural tube, and fetal death around embryonic day 14.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006338 VEGA Gene Model | MGI Sequence Detail 5235 C57BL/6J ±  kb
transcript OTTMUST00000014402 VEGA | MGI Sequence Detail 2129 Not Applicable  
polypeptide OTTMUSP00000006681 VEGA | MGI Sequence Detail 267 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    15 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000017476 X-box-binding protein 1
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
Molecular
Reagents
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  • All nucleic 656
    cDNA 640
    Primer pair 14
    Other 2

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-15468, MGI:1098709
References
more
  • Summaries
    All 163
    Developmental Gene Expression 40
    Gene Ontology 21
    Phenotypes 63
  • Earliest
    J:14524 Clauss IM, et al., In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn. 1993 Jun;197(2):146-56
  • Latest
    J:227034 Chan JY, et al., The balance between adaptive and apoptotic unfolded protein responses regulates beta-cell death under ER stress conditions through XBP1, CHOP and JNK. Mol Cell Endocrinol. 2015 Sep 15;413:189-201

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory