Xbp1
Gene Detail

Symbol

Name
ID

Xbp1
X-box binding protein 1
MGI:98970

Synonyms

D11Ertd39e, TREB5, TREB-5, XBP-1

Feature Type

protein coding gene

Genetic Map

Chromosome 11
3.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:5520659-5525893 bp, + strand From VEGA annotation of GRCm38   5235 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:3722  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog

Protein SuperFamily: X box-binding protein 1
Gene Tree: Xbp1

Human
homologs

Human Homolog		XBP1, X-box binding protein 1
NCBI Gene ID		7494
neXtProt AC		NX_P17861
Human Synonyms		TREB5, TREB-5, XBP-1, XBP2
Human Chr (Location)		22q12.1; chr22:28794560-28800572 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human XBP1

Mutations,
alleles, and
phenotypes

All mutations/alleles(21) : Gene trapped(7) Targeted(14)
 

Homozygous mutants exhibit markedly impaired liver development resulting in severe anemia, necrosis of cardiac myocytes, morphological abnormalities of the neural tube, and fetal death around embryonic day 14.

 

Interactions

Xbp1 interacts with 177 markers (Mir1b, Mir10b, Mir19a, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (120 annotations)

Process	adipose tissue development, angiogenesis, ...
Component	cell, cytoplasm, ...
Function	chromatin DNA binding, core promoter binding, ...

External Resources: FuncBase

Expression

Literature Summary: (38 records)

Data Summary: Results (216)    Tissues (109)    Images (45)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	11
RNA in situ	116
Western blot	11
RT-PCR	78

cDNA source data(639)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(656) cDNA(640) Primer pair(14) Other(2)
Microarray probesets(6)

Other database
links

VEGA Gene Model	OTTMUSG00000006338 (Evidence)
Ensembl Gene Model	ENSMUSG00000020484 (Evidence)
Entrez Gene	22433 (Evidence)
UniGene	469937
DFCI	TC1573995, TC1581376, TC1626706, TC1664431, TC1675223, TC1736635, TC1746839
DoTS	DT.101206153, DT.101305889, DT.110546222, DT.110546241, DT.87069884, DT.91345467, DT.94138632, DT.94138659, DT.97354287, DT.97355298
NIA Mouse Gene Index	U012281
Consensus CDS Project	CCDS24400.1
International Mouse Knockout Project Status	Xbp1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006338	VEGA Gene Model | MGI Sequence Detail	5235	C57BL/6J
transcript	OTTMUST00000014402	VEGA | MGI Sequence Detail	2129	Not Applicable
polypeptide	OTTMUSP00000006681	VEGA | MGI Sequence Detail	267	Not Applicable

All sequences(84) RefSeq(4) UniProt(4)

Polymorphisms

SNPs within 2kb(15 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR004827	Basic-leucine zipper domain
Protein Ontology	PR:000017476	X-box-binding protein 1

References

(Earliest) J:14524 Clauss IM, et al., In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn. 1993 Jun;197(2):146-56
(Latest) J:212913 Tang CH, et al., Inhibition of ER stress-associated IRE-1/XBP-1 pathway reduces leukemic cell survival. J Clin Invest. 2014 Jun 2;124(6):2585-98
All references(153)

Other
accession IDs

MGD-MRK-15468, MGI:1098709