Uox
Gene Detail

Symbol Name ID

Uox urate oxidase MGI:98907

Feature Type

protein coding gene

Genetic Map

Chromosome 3

72.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr3:146597077-146632305 bp, + strand From VEGA annotation of GRCm38   35229 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7584  Vertebrate Homology Class
1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: uricase
Gene Tree: Uox

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(1) Radiation induced(1)
 

Homozygous null mutants exhibit marked hyperuricemia and urate nephropathy. Most mutants die prior to four weeks of age. Homozygotes for a large paracentric inversion disrupting this same gene exhibit a similar phenotype.

 
Human Diseases Modeled Using Mouse Uox (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	oxidation-reduction process, purine nucleobase metabolic process
Component	mitochondrion, peroxisome
Function	oxidoreductase activity, urate oxidase activity

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (188)    Tissues (94)    Images (12)
Theiler Stages: 22

Assay Type	Results
RNA in situ	188

cDNA source data(117)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(120) Genomic(2) cDNA(117) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000029704 (Evidence)
Ensembl Gene Model	ENSMUSG00000028186 (Evidence)
Entrez Gene	22262 (Evidence)
UniGene	10865
DFCI	TC1576756
DoTS	DT.495819
NIA Mouse Gene Index	U003963
EC	1.7.3.3
Consensus CDS Project	CCDS17905.1
International Mouse Knockout Project Status	Uox

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029704	VEGA Gene Model | MGI Sequence Detail	35229	C57BL/6J
transcript	OTTMUST00000073703	VEGA | MGI Sequence Detail	2737	Not Applicable
polypeptide	OTTMUSP00000038195	VEGA | MGI Sequence Detail	303	Not Applicable

All sequences(29) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(276 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002042	Uricase
InterPro	IPR019842	Uricase, conserved site
Protein Ontology	PR:000017226	uricase

References

(Earliest) J:25456 Holmes RS, et al., Genetics of mouse Peroxisomal Enzymes. Mouse News Lett. 1976;54:32-33
(Latest) J:192527 Chen X, et al., Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):300-5
All references(37)

Other accession IDs

MGD-MRK-15358, MGI:2139782