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Uox
Gene Detail
 Symbol
Name
ID
Uox
urate oxidase
MGI:98907
Feature Type protein coding gene
Genetic Map
Chromosome 3
72.09 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr3:146597077-146632305 bp, + strand
From VEGA annotation of GRCm38

  35229 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7584  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: uricase
Gene Tree: Uox

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Radiation induced(1) Targeted(2)
Incidental mutations (data from APF )
 
Homozygous null mutants exhibit marked hyperuricemia and urate nephropathy. Most mutants die prior to four weeks of age. Homozygotes for a large paracentric inversion disrupting this same gene exhibit a similar phenotype.
 
Human Diseases Modeled Using Mouse Uox (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Uox interacts with 189 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process oxidation-reduction process, purine nucleobase metabolic process
Component mitochondrion, peroxisome
Function oxidoreductase activity, urate oxidase activity
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (188)    Tissues (94)    Images (12)
Theiler Stages: 22
Assay TypeResults
RNA in situ 188
cDNA source data(117)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(120) Genomic(2) cDNA(117) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029704 (Evidence)
Ensembl Gene ModelENSMUSG00000028186 (Evidence)
Entrez Gene22262 (Evidence)
UniGene10865
DFCITC1576756
DoTSDT.495819
NIA Mouse Gene IndexU003963
EC1.7.3.3
Consensus CDS ProjectCCDS17905.1
International Mouse Knockout Project StatusUox
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029704 VEGA Gene Model | MGI Sequence Detail 35229 C57BL/6J ±  kb
transcript OTTMUST00000073703 VEGA | MGI Sequence Detail 2737 Not Applicable 
polypeptide OTTMUSP00000038195 VEGA | MGI Sequence Detail 303 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(2) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(357 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002042 Uricase
InterPro IPR019842 Uricase, conserved site
Protein Ontology PR:000017226 uricase
References (Earliest) J:25456 Holmes RS, et al., Genetics of mouse Peroxisomal Enzymes. Mouse News Lett. 1976;54:32-33
(Latest) J:192527 Chen X, et al., Disrupted and transgenic urate oxidase alter urate and dopaminergic neurodegeneration. Proc Natl Acad Sci U S A. 2013 Jan 2;110(1):300-5
All references(37)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15358, MGI:2139782

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory