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Uox Gene Detail
Summary
  • Symbol
    Uox
  • Name
    urate oxidase
  • Feature Type
    protein coding gene
  • IDs
    MGI:98907
    NCBI Gene: 22262
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:146302904-146337238 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 72.09 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1111 from dbSNP Build 142
  • Strain Annotations
    14
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98907
 protein coding gene Chr3:146276181-146338060 (+)
129S1/SvImJ ENSMUSG00200003583
 protein coding gene Chr3:143197218-143259684 (+)
A/J ENSMUSG00195003358
 protein coding gene Chr3:143310346-143372375 (+)
AKR/J ENSMUSG00220000409
 protein coding gene Chr3:141725096-141787581 (+)
BALB/cJ ENSMUSG00180023173
 protein coding gene Chr3:143180758-143242792 (+)
C3H/HeJ ENSMUSG00175018448
 protein coding gene Chr3:142762745-142824749 (+)
C57BL/6NJ ENSMUSG00215009899
 protein coding gene Chr3:143465615-143527679 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025727
 protein coding gene Chr3:139760842-139821919 (+)
CAST/EiJ no annotation
CBA/J ENSMUSG00210003696
 protein coding gene Chr3:143440128-143502100 (+)
DBA/2J ENSMUSG00185023500
 protein coding gene Chr3:144030219-144092687 (+)
FVB/NJ ENSMUSG00205019211
 protein coding gene Chr3:142305694-142367706 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230018400
 protein coding gene Chr3:145950604-146013073 (+)
NOD/ShiLtJ ENSMUSG00190004033
 protein coding gene Chr3:144400047-144462308 (+)
NZO/HlLtJ ENSMUSG00225002563
 protein coding gene Chr3:148461946-148523970 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    UOX, urate oxidase (pseudogene)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UOX, urate oxidase (pseudogene)
  • Synonyms
    UOXP, URICASE
  • Links
    NCBI Gene ID: 391051

  • Chr Location
    1p31.1; chr1:84364958-84397831 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Uox mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 3 alleles in 3 genetic backgrounds
    10 phenotypes from multigenic genotypes
    1 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit marked hyperuricemia and urate nephropathy. Most mutants die prior to four weeks of age. Homozygotes for a large paracentric inversion disrupting this same gene exhibit a similar phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    799
  • Tissues
    97
  • cDNA Data
    118
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22262 NCBI Gene Model | MGI Sequence Detail 34335 C57BL/6J ±  kb
    transcript NM_009474 RefSeq | MGI Sequence Detail 1843 C57BL/6  
    polypeptide P25688 UniProt | EBI | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 121
      Genomic 2
      cDNA 118
      Primer pair 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15358, MGI:2139782
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 2
      Diseases 4
      Gene Ontology 13
      Phenotypes 38
    • Earliest
      J:297524 Lee PC, Developmental changes of adenosine deaminase, xanthine oxidase, and uricase in mouse tissues. Dev Biol. 1973 Apr;31(2):227-33
    • Latest
      J:377320 Chen J, et al., Activation of mitophagy antagonizes high uric acid-induced hepatic lipid accumulation. J Biol Chem. 2025 Dec 13;302(2):111054
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory