Uox Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Uox
urate oxidase
MGI:98907

50 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Uox^{em1(IMPC)Ccpcz}/Uox⁺ C57BL/6NCrl-Uox^{em1(IMPC)Ccpcz}/Ccpcz	abnormal pancreas morphology	J:211773
	enlarged pancreas	J:211773
	small pancreas	J:211773
Uox^{em1(IMPC)Ccpcz}/Uox^{em1(IMPC)Ccpcz} C57BL/6NCrl-Uox^{em1(IMPC)Ccpcz}/Ccpcz	preweaning lethality, complete penetrance	J:211773
Uox^em1Cli/Uox^em1Cli C57BL/6J-Uox^em1Cli	abnormal cytokine level	J:271949
	abnormal kidney interstitium morphology	J:271949
	abnormal kidney morphology	J:271949
	abnormal nephron morphology	J:271949
	decreased circulating triglyceride level	J:271949
	decreased insulin secretion	J:271949
	decreased pancreatic beta cell mass	J:271949
	decreased survivor rate	J:271949
	dilated renal tubule	J:271949
	impaired glucose tolerance	J:271949
	increased blood urea nitrogen level	J:271949
	increased blood uric acid level	J:271949
	increased circulating cholesterol level	J:271949
	increased circulating creatinine level	J:271949
	increased circulating LDL cholesterol level	J:271949
	increased circulating triglyceride level	J:271949
	increased glomerular capsule space	J:271949
	increased pancreatic beta cell apoptosis	J:271949
	increased susceptibility to non-insulin-dependent diabetes	J:271949
	increased systemic arterial blood pressure	J:271949
	kidney inflammation	J:271949
	nephron necrosis	J:271949
	premature death	J:271949
	renal interstitial fibrosis	J:271949
Uox^tm1Bay/Uox^tm1Bay involves: 129S7/SvEvBrd * C57BL/6J	abnormal kidney morphology	J:16490, J:103187
	abnormal nephron morphology	J:16490
	abnormal renal glomerulus morphology	J:103187
	abnormal renal tubule morphology	J:16490
	abnormal urine color	J:103187
	crystalluria	J:103187
	cystolithiasis	J:103187
	decreased urine osmolality	J:103187
	dilated kidney collecting duct	J:103187
	dilated renal tubule	J:16490
	distended urinary bladder	J:103187
	hydronephrosis	J:16490, J:103187
	increased blood urea nitrogen level	J:103187
	increased blood uric acid level	J:16490
	increased glomerular capsule space	J:16490
	increased urine uric acid level	J:16490, J:103187
	kidney cortex cyst	J:16490
	kidney cyst	J:16490
	pale kidney	J:16490
	polydipsia	J:103187
	polyuria	J:103187
	premature death	J:16490
	renal cast	J:16490
	renal fibrosis	J:103187
	renal glomerulus atrophy	J:16490
	renal tubule atrophy	J:103187
	small kidney	J:16490
	tubulointerstitial nephritis	J:16490
	uremia	J:103187

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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