Uoxⁱⁿ
Radiation induced Allele Detail

Summary

• Symbol: Uoxⁱⁿ
• Name: urate oxidase; urate oxidase In(3)55Rk-induced
• MGI ID: MGI:2157909
• Gene: Uox Location: Chr3:146302904-146337238 bp, + strand Genetic Position: Chr3, 72.09 cM
• Alliance: Uoxⁱⁿ page

Mutation origin

• Strain of Origin: DBA/2J

Mutation description

• Allele Type: Radiation induced
• Mutation: Inversion
• Uoxⁱⁿ involves 1812 genes/genome features (Gm6731, 4930449A18Rik, Gm10959 ...) View all
• Mutation details: PCR analysis on genomic DNA derived from mice carrying the In(3)55K inversion suggests that a disruption 3' to base 844 of exon 7 results in the mutation. Northern blot analysis on mRNA derived from liver RNA of homozygous mice confirmed that negligible amounts of encoded transcript was produced from this allele. (J:70677)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Uox Mutation: 31 strains or lines available

Notes

See also In(3)55Rk-d and In(3)55Rk-p.

References

• Original: J:70677 Cook SA, et al., Mouse paracentric inversion In(3)55Rk mutates the urate oxidase gene. Cytogenet Cell Genet. 2001;93(1-2):77-82
• All: 2 reference(s)