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Txn1
Gene Detail
Symbol

Name
ID
Txn1
thioredoxin 1
MGI:98874
Synonyms
Trx1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
31.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr4:57943373-57956411 bp, - strand
From VEGA annotation of GRCm38

  13039 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128202  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: Thioredoxin
Gene Tree: Txn1

Human
homologs
Human Homolog TXN, thioredoxin
NCBI Gene ID 7295
neXtProt AC  NX_P10599
Human Synonyms  TRDX, TRX, TRX1
Human Chr (Location)  9q31; chr9:110243812-110256640 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(12) Targeted(1)
 
Homozygotes for a targeted null mutation die soon after implantation. In vitro, mutant embryos do not hatch, inner cell mass cells fail to proliferate, and trophoblasts do not attach to the feeder layer.
 
Interactions
Txn1 interacts with 75 markers (Mir15a, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cell redox homeostasis, glycerol ether metabolic process, ...
Component axon, cytoplasm, ...
Function enzyme binding, peptide disulfide oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (38)    Tissues (3)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 38
cDNA source data(178)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(184) Genomic(5) cDNA(179)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000007384 (Evidence)
Ensembl Gene ModelENSMUSG00000028367 (Evidence)
Entrez Gene22166 (Evidence)
UniGene260618
DFCITC1573530
DoTSDT.101143311, DT.110810320, DT.55189762
NIA Mouse Gene IndexU025109
Consensus CDS ProjectCCDS18207.1
International Mouse Knockout Project StatusTxn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007384 VEGA Gene Model | MGI Sequence Detail 13039 C57BL/6J ±  kb
transcript OTTMUST00000017076 VEGA | MGI Sequence Detail 1051 Not Applicable 
polypeptide OTTMUSP00000007887 VEGA | MGI Sequence Detail 105 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005746 Thioredoxin
InterPro IPR017937 Thioredoxin, conserved site
InterPro IPR013766 Thioredoxin domain
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000016853 thioredoxin
References
(Earliest) J:38106 Tagaya Y, et al., ATL-derived factor (ADF), an IL-2 receptor/Tac inducer homologous to thioredoxin; possible involvement of dithiol-reduction in the IL-2 receptor induction [published erratum appears in EMBO J 1994 May 1;13(9):2244]. EMBO J. 1989 Mar;8(3):757-64
(Latest) J:210537 Shao D, et al., A redox-dependent mechanism for regulation of AMPK activation by Thioredoxin1 during energy starvation. Cell Metab. 2014 Feb 4;19(2):232-45
All references(55)
Other
accession IDs
MGD-MRK-15309, MGI:2140594

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory