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Ttr
Gene Detail
 Symbol
Name
ID
Ttr
transthyretin
MGI:98865
Synonyms prealbumin
Feature Type protein coding gene
Genetic Map
Chromosome 18
11.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr18:20665250-20674324 bp, + strand
From Ensembl annotation of GRCm38

  9075 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transthyretin/transthyretin-related protein
Gene Tree: Ttr

Human
homologs
Human Homolog TTR, transthyretin
NCBI Gene ID 7276
neXtProt AC  NX_P02766
Human Synonyms  CTS, CTS1, HEL111, HsT2651, PALB, TBPA
Human Chr (Location)  18q12.1; chr18:31591767-31599024 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human TTR
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(5) Targeted(11)
 
Homozygous mutation of this gene results in decreased circulating thyroxine, triiodothyronine, and retinol levels.
 
Interactions
Ttr interacts with 91 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process retinol metabolic process, transport
Component extracellular region, extracellular space, ...
Function hormone activity, hormone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (77 records)
Data Summary: Results (405)    Tissues (235)    Images (80)
Theiler Stages: 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 377
Northern blot 20
RT-PCR 8
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(49) Genomic(11) cDNA(26) Primer pair(8) Other(4)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000061808 (Evidence)
Entrez Gene22139 (Evidence)
DFCITC1573877
DoTSDT.101269788, DT.40155904, DT.94152542, DT.97385642, DT.99870961
NIA Mouse Gene IndexU096355
PDB2QPF
Consensus CDS ProjectCCDS29085.1
International Mouse Knockout Project StatusTtr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061808 Ensembl Gene Model | MGI Sequence Detail 9075 C57BL/6J ±  kb
transcript ENSMUST00000075312 Ensembl | MGI Sequence Detail 1219 Not Applicable 
polypeptide ENSMUSP00000074783 Ensembl | MGI Sequence Detail 147 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(3)
Polymorphisms All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023419 Transthyretin, conserved site
InterPro IPR000895 Transthyretin/hydroxyisourate hydrolase
InterPro IPR023416 Transthyretin/hydroxyisourate hydrolase, superfamily
InterPro IPR023418 Transthyretin, thyroxine binding site
Protein Ontology PR:000016801 transthyretin
References (Earliest) J:14652 Wakasugi S, et al., Structural comparisons between mouse and human prealbumin. J Biochem. 1985 Dec;98(6):1707-14
(Latest) J:211347 Wang X, et al., The systemic amyloid precursor transthyretin (TTR) behaves as a neuronal stress protein regulated by HSF1 in SH-SY5Y human neuroblastoma cells and APP23 Alzheimer's disease model mice. J Neurosci. 2014 May 21;34(21):7253-65
All references(175)
Other
accession IDs
MGD-MRK-15296, MGI:2147169, MGI:2147263, MGI:2147418

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory