Ttr
Gene Detail

Symbol Name ID

Ttr transthyretin MGI:98865

Synonyms

prealbumin

Feature Type

protein coding gene

Genetic Map

Chromosome 18

11.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(25)

Sequence Map

Chr18:20665250-20674324 bp, + strand From Ensembl annotation of GRCm38   9075 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transthyretin/transthyretin-related protein
Gene Tree: Ttr

Human homologs

Human Homolog		TTR, transthyretin
NCBI Gene ID		7276
neXtProt AC		NX_P02766
Human Synonyms		CTS, CTS1, HsT2651, PALB, TBPA
Human Chr (Location)		18q12.1; chr18:29171730-29178987 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human TTR

Alleles and phenotypes

All alleles(16) : Targeted(11) Gene trapped(5)
 

Homozygous mutation of this gene results in decreased circulating thyroxine, triiodothyronine, and retinol levels.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	retinol metabolic process, transport
Component	extracellular region, extracellular space, ...
Function	hormone activity, hormone binding, ...

External Resources: FuncBase

Expression

Literature Summary: (73 records)
Data Summary: Results (386)    Tissues (216)    Images (78)
Theiler Stages: 11, 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	360
Northern blot	20
RT-PCR	6

cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(48) Genomic(11) cDNA(26) Primer pair(7) Other(4)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000061808 (Evidence)
Entrez Gene	22139 (Evidence)
DFCI	TC1573877
DoTS	DT.101269788, DT.40155904, DT.94152542, DT.97385642, DT.99870961
NIA Mouse Gene Index	U096355
PDB	2QPF
Consensus CDS Project	CCDS29085.1
International Mouse Knockout Project Status	Ttr

Sequences

Length	Strain/Species
genomic	ENSMUSG00000061808	Ensembl Gene Model | MGI Sequence Detail	9075	C57BL/6J
transcript	ENSMUST00000075312	Ensembl | MGI Sequence Detail	1219	Not Applicable
polypeptide	ENSMUSP00000074783	Ensembl | MGI Sequence Detail	147	Not Applicable

All sequences(42) RefSeq(2) UniProt(3)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(98 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023419	Transthyretin, conserved site
InterPro	IPR000895	Transthyretin/hydroxyisourate hydrolase
InterPro	IPR023416	Transthyretin/hydroxyisourate hydrolase, superfamily
InterPro	IPR023418	Transthyretin, thyroxine binding site
Protein Ontology	PR:000016801	transthyretin

References

(Earliest) J:14652 Wakasugi S, et al., Structural comparisons between mouse and human prealbumin. J Biochem. 1985 Dec;98(6):1707-14
(Latest) J:194049 Johansson PA, et al., The transcription factor Otx2 regulates choroid plexus development and function. Development. 2013 Mar;140(5):1055-66
All references(164)

Other accession IDs

MGD-MRK-15296, MGI:2147169, MGI:2147263, MGI:2147418