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Ttr
Gene Detail
Symbol

Name
ID
Ttr
transthyretin
MGI:98865
Synonyms
prealbumin
Feature Type
protein coding gene
Genetic Map
Chromosome 18
11.47 cM
Detailed Genetic Map ± 1 cM


Mapping data(25)
Sequence Map
Chr18:20665250-20674324 bp, + strand
From Ensembl annotation of GRCm38

  9075 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:317  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TTR
Protein SuperFamily: transthyretin/transthyretin-related protein
Gene Tree: Ttr

Human
homologs
TTR, transthyretin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7276
neXtProt AC: NX_P02766

Human Synonyms: CTS, CTS1, HEL111, HsT2651, PALB, TBPA

Human Chr (Location): 18q12.1; chr18:31591767-31599024 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human TTR

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(5) Targeted(12)
Incidental mutations (data from CvDC )
 
Homozygous mutation of this gene results in decreased circulating thyroxine, triiodothyronine, and retinol levels.
 
Interactions
Ttr interacts with 91 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process retinol metabolic process, thyroid hormone transport, ...
Component extracellular exosome, extracellular region, ...
Function hormone activity, hormone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (82 records)
Data Summary: Results (403)    Tissues (233)    Images (80)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 375
Northern blot 20
RT-PCR 8
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA TTR ; Xenbase ttr ; ZFIN ttr    NEW 
Molecular
reagents
All nucleic(49) Genomic(11) cDNA(26) Primer pair(8) Other(4)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000061808 (Evidence)
Entrez Gene 22139 (Evidence)
DFCI TC1573877
DoTS DT.101269788, DT.40155904, DT.94152542, DT.97385642, DT.99870961
NIA Mouse Gene Index U096355
PDB 2QPF
Consensus CDS Project CCDS29085.1
International Mouse Phenotyping Consortium Status Ttr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061808 Ensembl Gene Model | MGI Sequence Detail 9075 C57BL/6J ±  kb
transcript ENSMUST00000075312 Ensembl | MGI Sequence Detail 1219 Not Applicable 
polypeptide ENSMUSP00000074783 Ensembl | MGI Sequence Detail 147 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(3)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023419 Transthyretin, conserved site
InterPro IPR000895 Transthyretin/hydroxyisourate hydrolase
InterPro IPR023416 Transthyretin/hydroxyisourate hydrolase, superfamily
InterPro IPR023418 Transthyretin, thyroxine binding site
Protein Ontology PR:000016801 transthyretin
References
(Earliest) J:14652 Wakasugi S, et al., Structural comparisons between mouse and human prealbumin. J Biochem. 1985 Dec;98(6):1707-14
(Latest) J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16
All references(180)
Other
accession IDs
MGD-MRK-15296, MGI:2147169, MGI:2147263, MGI:2147418

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory