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Rbp4tm1(RBP4)Zhel
Targeted Allele Detail
Summary
Symbol: Rbp4tm1(RBP4)Zhel
Name: retinol binding protein 4, plasma; targeted mutation 1, Zhenghua Li
MGI ID: MGI:5749289
Synonyms: hVal30:hRBP4, mRbp4hRBP4
Gene: Rbp4  Location: Chr19:38105077-38113729 bp, - strand  Genetic Position: Chr19, 32.75 cM, cytoband D1
Alliance: Rbp4tm1(RBP4)Zhel page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:220321
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence, RMCE-ready)
Mutation:    Insertion
 
Rbp4tm1(RBP4)Zhel expresses 1 gene
 
Mutation detailsES cells containing the Rbp4tm2Zhel null allele that serves as an acceptor in recombination mediated cassette exchange were electroporated with a replacement vector and a cre recombinase expression vector. The replacement vector consisted of a wild-type human RBP4 cDNA and a FRT-flanked puromycin resistance gene flanked by a loxKMR3 and a loxP site. (J:220321, J:260683)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rbp4 Mutation:  19 strains or lines available
References
Original:  J:220321 Mu Y, et al., CHF5074 (CSP-1103) stabilizes human transthyretin in mice humanized at the transthyretin and retinol-binding protein loci. FEBS Lett. 2015 Mar 24;589(7):849-56
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory