Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rbp4tm2Zhel
Name:	retinol binding protein 4, plasma; targeted mutation 2, Zhenghua Li
MGI ID:	MGI:6196354
Synonyms:	Rbp4-
Gene:	Rbp4  Location: Chr19:38105077-38113729 bp, - strand  Genetic Position: Chr19, 32.75 cM, cytoband D1
Alliance:	Rbp4tm2Zhel page

Germline Transmission:	Earliest citation of germline transmission: J:260684
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout, RMCE-ready) Mutations:    Insertion, Intragenic deletion   Mutation details: A null allele was created by replacing the ATG start site within exon 2 with a PGK-neo cassette flanked by lox71 and loxP sites. Besides disrupting the gene, the cassette also serves as an acceptor in recombination mediated cassette exchange (RMCE). RT-PCR confirmed absence of mRNA in the brain, lung, liver, and kidney. Northern blots of liver RNA and Western blots of serum confirmed absence of mRNA and protein, respectively. (J:260684)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

6 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rbp4 Mutation:	19 strains or lines available

Original:	J:260684 Shen J, et al., Severe ocular phenotypes in Rbp4-deficient mice in the C57BL/6 genetic background. Lab Invest. 2016 Jun;96(6):680-91
All:	3 reference(s)