Trhr
Gene Detail

Symbol Name ID

Trhr thyrotropin releasing hormone receptor MGI:98824

Synonyms

TRH-R1

Feature Type

protein coding gene

Genetic Map

Chromosome 15

16.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr15:44196135-44235912 bp, + strand From NCBI annotation of GRCm38   39778 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20707  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: thyrotropin-releasing hormone receptor
Gene Tree: Trhr

Human homologs

Human Homolog		TRHR, thyrotropin-releasing hormone receptor
NCBI Gene ID		7201
neXtProt AC		NX_P34981
Human Synonyms		TRH-R
Human Chr (Location)		8q23; chr8:110099653-110131813 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TRHR

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygous null mice are fertile and display decreased thyroxine, triiodothyronine, and prolactin levels.

 
Human Diseases Modeled Using Mouse Trhr (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	elevation of cytosolic calcium ion concentration, G-protein coupled receptor signaling pathway, ...
Component	cell surface, integral to membrane, ...
Function	G-protein coupled receptor activity, protein homodimerization activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (97)    Tissues (97)    Images (17)
Theiler Stages: 9, 11, 13, 22, 28

Assay Type	Results
RNA in situ	93
RT-PCR	4

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(16) Genomic(2) cDNA(12) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000038760 (Evidence)
Entrez Gene	22045 (Evidence)
UniGene	309350
DFCI	TC1587775, TC1596643
DoTS	DT.110803031, DT.483275
NIA Mouse Gene Index	U016224
Consensus CDS Project	CCDS37068.1
International Mouse Knockout Project Status	Trhr

Sequences

Length	Strain/Species
genomic	22045	NCBI Gene Model | MGI Sequence Detail	39778	C57BL/6J
transcript	NM_013696	RefSeq | MGI Sequence Detail	3976	C57BL/6
polypeptide	P21761	UniProt | EBI | MGI Sequence Detail	393	Not Applicable

All sequences(28) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(265 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
InterPro	IPR002120	Thyrotrophin-releasing hormone receptor
InterPro	IPR009144	Thyrotropin-releasing hormone receptor
Protein Ontology	PR:000001557	thyrotropin-releasing hormone receptor

Graphical View of Protein Domain Structure

References

(Earliest) J:10900 Straub RE, et al., Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9514-8
(Latest) J:190867 Sun Y, et al., Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement. Nat Genet. 2012 Dec;44(12):1375-81
All references(47)

Other accession IDs

MGD-MRK-15227