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Trhr Gene Detail
Summary
  • Symbol
    Trhr
  • Name
    thyrotropin releasing hormone receptor
  • Synonyms
    TRH-R1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98824
    NCBI Gene: 22045
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr15:44196135-44235912 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 16.82 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    331 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98824
protein coding gene Chr15:44195924-44235912 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021828
protein coding gene Chr15:42789751-42834247 (+)
A/J MGP_AJ_G0021788
protein coding gene Chr15:41167270-41209187 (+)
AKR/J MGP_AKRJ_G0021769
protein coding gene Chr15:42385478-42424971 (+)
BALB/cJ MGP_BALBcJ_G0021795
protein coding gene Chr15:41251596-41294926 (+)
C3H/HeJ MGP_C3HHeJ_G0021569
protein coding gene Chr15:42305447-42345953 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022234
protein coding gene Chr15:44463138-44508497 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019771
protein coding gene Chr15:38712417-38762950 (+)
CAST/EiJ MGP_CASTEiJ_G0021086
protein coding gene Chr15:42827780-42873198 (+)
CBA/J MGP_CBAJ_G0021538
protein coding gene Chr15:45997845-46048685 (+)
DBA/2J MGP_DBA2J_G0021662
protein coding gene Chr15:40967106-41013723 (+)
FVB/NJ MGP_FVBNJ_G0021640
protein coding gene Chr15:40280085-40318818 (+)
LP/J MGP_LPJ_G0021732
protein coding gene Chr15:42563514-42604235 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021664
protein coding gene Chr15:49373511-49415793 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022257
protein coding gene Chr15:42576819-42617969 (+)
PWK/PhJ MGP_PWKPhJ_G0020831
protein coding gene Chr15:41027549-41066563 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020668
protein coding gene Chr15:42267993-42305990 (+)
WSB/EiJ MGP_WSBEiJ_G0021141
protein coding gene Chr15:42467683-42514688 (+)



Homology
more
  • Human Ortholog
    TRHR, thyrotropin releasing hormone receptor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TRHR, thyrotropin releasing hormone receptor
    Orthology source: HGNC, HomoloGene
  • Synonyms
    TRH-R
  • Links
    NCBI Gene ID: 7201
    neXtProt AC: NX_P34981
    UniProt: P34981

  • Chr Location
    8q23.1; chr8:109085745-109119785 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Trhr mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are fertile and display decreased thyroxine, triiodothyronine, and prolactin levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038760 Ensembl Gene Model | MGI Sequence Detail 39778 C57BL/6J ±  kb
    transcript ENSMUST00000110289 Ensembl | MGI Sequence Detail 1745 Not Applicable  
    polypeptide ENSMUSP00000105918 Ensembl | MGI Sequence Detail 393 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 2
      cDNA 13
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15227
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:252758 Muller-Fielitz H, et al., Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis. Nat Commun. 2017 Sep 07;8(1):484

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory