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Trhr
Gene Detail
 Symbol
Name
ID
Trhr
thyrotropin releasing hormone receptor
MGI:98824
Synonyms TRH-R1
Feature Type protein coding gene
Genetic Map
Chromosome 15
16.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr15:44196135-44235912 bp, + strand
From NCBI annotation of GRCm38

  39778 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20707  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: thyrotropin-releasing hormone receptor
Gene Tree: Trhr

Human
homologs
Human Homolog TRHR, thyrotropin-releasing hormone receptor
NCBI Gene ID 7201
neXtProt AC  NX_P34981
Human Synonyms  TRH-R
Human Chr (Location)  8q23; chr8:109087424-109119584 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TRHR
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are fertile and display decreased thyroxine, triiodothyronine, and prolactin levels.
 
Human Diseases Modeled Using Mouse Trhr (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Trhr interacts with 336 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process G-protein coupled receptor signaling pathway, positive regulation of cytosolic calcium ion concentration, ...
Component cell surface, integral component of membrane, ...
Function G-protein coupled receptor activity, protein homodimerization activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (97)    Tissues (97)    Images (17)
Theiler Stages: 9, 11, 13, 22, 28
Assay TypeResults
RNA in situ 93
RT-PCR 4
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(12) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000038760 (Evidence)
Entrez Gene22045 (Evidence)
UniGene309350
DFCITC1587775, TC1596643
DoTSDT.110803031, DT.483275
NIA Mouse Gene IndexU016224
Consensus CDS ProjectCCDS37068.1
International Mouse Knockout Project StatusTrhr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 22045 NCBI Gene Model | MGI Sequence Detail 39778 C57BL/6J ±  kb
transcript NM_013696 RefSeq | MGI Sequence Detail 3976 C57BL/6 
polypeptide P21761 UniProt | EBI | MGI Sequence Detail 393 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(333 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR002120 Thyrotrophin-releasing hormone receptor
Protein Ontology PR:000001557 thyrotropin-releasing hormone receptor
Graphical View of Protein Domain Structure
References (Earliest) J:10900 Straub RE, et al., Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9514-8
(Latest) J:190867 Sun Y, et al., Loss-of-function mutations in IGSF1 cause an X-linked syndrome of central hypothyroidism and testicular enlargement. Nat Genet. 2012 Dec;44(12):1375-81
All references(47)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15227

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory