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Trhr
Gene Detail
Symbol

Name
ID
Trhr
thyrotropin releasing hormone receptor
MGI:98824
Synonyms
TRH-R1
Feature Type
protein coding gene
Genetic Map
Chromosome 15
16.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr15:44196135-44235912 bp, + strand
From Ensembl annotation of GRCm38

  39778 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20707  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: TRHR
Protein SuperFamily: thyrotropin-releasing hormone receptor
Gene Tree: Trhr

Human
homologs
TRHR, thyrotropin-releasing hormone receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7201
neXtProt AC: NX_P34981

Human Synonyms: TRH-R

Human Chr (Location): 8q23; chr8:109086342-109119584 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TRHR

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice are fertile and display decreased thyroxine, triiodothyronine, and prolactin levels.
 
Human Diseases Modeled in Mice Using Trhr (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Trhr interacts with 335 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (97)    Tissues (97)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 93
RT-PCR 4
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(16) Genomic(2) cDNA(12) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000038760 (Evidence)
Entrez Gene 22045 (Evidence)
UniGene 309350
DFCI TC1587775, TC1596643
DoTS DT.110803031, DT.483275
NIA Mouse Gene Index U016224
Consensus CDS Project CCDS37068.1
International Mouse Phenotyping Consortium Status Trhr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038760 Ensembl Gene Model | MGI Sequence Detail 39778 C57BL/6J ±  kb
transcript ENSMUST00000110289 Ensembl | MGI Sequence Detail 1745 Not Applicable 
polypeptide ENSMUSP00000105918 Ensembl | MGI Sequence Detail 393 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(333 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR002120 Thyrotrophin-releasing hormone receptor
Protein Ontology PR:000001557 thyrotropin-releasing hormone receptor
References
(Earliest) J:10900 Straub RE, et al., Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9514-8
(Latest) J:220755 Mayerl S, et al., Absence of TRH receptor 1 in male mice affects gastric ghrelin production. Endocrinology. 2015 Feb;156(2):755-67
All references(45)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15227

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory