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Trhr Gene Detail
Summary
  • Symbol
    Trhr
  • Name
    thyrotropin releasing hormone receptor
  • Synonyms
    TRH-R1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98824
    NCBI Gene: 22045
Location & Maps
more
  • Sequence Map
    Chr15:44196135-44235912 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39778 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 16.82 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    TRHR, thyrotropin releasing hormone receptor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    TRHR, thyrotropin releasing hormone receptor
    Orthology source: HomoloGene
  • Synonyms
    TRH-R
  • Links
    NCBI Gene ID: 7201
    neXtProt AC: NX_P34981

  • Chr Location
    8q23; chr8:109086342-109119584 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Trhr mouse models; 1 with human TRHR associations

Human Disease Mouse Models
       Thyrotropin-Releasing Hormone Receptor; TRHR   OMIM: 188545 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    2
  • Gene trapped
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Trhr
  • Incidental Mutations
Homozygous null mice are fertile and display decreased thyroxine, triiodothyronine, and prolactin levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038760 Ensembl Gene Model | MGI Sequence Detail 39778 C57BL/6J ±  kb
transcript ENSMUST00000110289 Ensembl | MGI Sequence Detail 1745 Not Applicable  
polypeptide ENSMUSP00000105918 Ensembl | MGI Sequence Detail 393 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    331 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001557 thyrotropin-releasing hormone receptor
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR002120 Thyrotropin-releasing hormone receptor
Molecular
Reagents
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  • All nucleic 16
    Genomic 2
    cDNA 12
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-15227
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Diseases 1
    Gene Ontology 3
    Phenotypes 13
  • Earliest
    J:10900 Straub RE, et al., Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9514-8
  • Latest
    J:220755 Mayerl S, et al., Absence of TRH receptor 1 in male mice affects gastric ghrelin production. Endocrinology. 2015 Feb;156(2):755-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory