Trhr^tm1Bau
Targeted Allele Detail

Summary

• Symbol: Trhr^tm1Bau
• Name: thyrotropin releasing hormone receptor; targeted mutation 1, Karl Bauer
• MGI ID: MGI:3044170
• Synonyms: THR-R1^-, trhr1ko
• Gene: Trhr Location: Chr15:44059531-44099308 bp, + strand Genetic Position: Chr15, 16.82 cM
• Alliance: Trhr^tm1Bau page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:90365
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The complete coding region encompassing the transcriptional start site in exon 2 and spanning part of exon 5 was replaced with LacZ and neo cassettes. Northern blot confirmed absence of transcript in pituitary glands of mutants. (J:90365)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trhr Mutation: 31 strains or lines available

References

• Original: J:90365 Rabeler R, et al., Generation of thyrotropin-releasing hormone receptor 1-deficient mice as an animal model of central hypothyroidism. Mol Endocrinol. 2004 Jun;18(6):1450-60
• All: 4 reference(s)