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Phenotypes Associated with This Genotype
Genotype
MGI:5637537
Allelic
Composition
Trhrtm1Bau/Trhrtm1Bau
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trhrtm1Bau mutation (0 available); any Trhr mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• mice exhibit central hypothyroidism

growth/size/body
• in hypothyroid mutants
• fasting-induced weight loss is higher in hypothyroid and euthyroid mutants than in wild-type mice

homeostasis/metabolism
• hypothyroid mutants under fasting conditions show only a marginal elevation in serum ghrelin levels compared to fasting wild-type mice or euthyroid mutants
• acylated ghrelin levels in the serum are similar in hypothyroid and euthyroid mutants as in wild-type mice under feeding conditions
• the fasting-induced rise in acylated ghrelin that is seen in wild-type mice is diminished in hypothyroid and in euthyroid mutants
• hypothyroid mutants show elevated total ghrelin serum levels under feeding conditions compared to euthyroid mutants and wild-type mice
• mice rendered euthyroid by thyroid hormone treatment before fasting show lower serum thyroid hormone levels
• however, serum thyroid hormone levels do not change in hypothyroid mutants upon fasting
• approximate 50% reduction in serum T3 and T4 concentrations
• approximate 50% reduction in serum T3 and T4 concentrations
• increase in oxygen consumption under conditions of ad libitum food accessibility
• hypothyroid mutants display similar oxygen consumption and locomotor activity values under fasting and feeding conditions in the first hours of the dark period unlike wild-type mice which show a mild reduction in oxygen consumption and lower locomotor activity under food deprivation conditions
• however, oxygen consumption and locomotor activity decline in the second half of the fasting period as in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
congenital hypothyroidism DOID:0050328 OMIM:PS275200
J:220755


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
06/12/2024
MGI 6.13
The Jackson Laboratory