Tpmt
Gene Detail

Symbol Name ID

Tpmt thiopurine methyltransferase MGI:98812

Feature Type

protein coding gene

Genetic Map

Chromosome 13

24.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr13:47025170-47044737 bp, - strand From VEGA annotation of GRCm38   19568 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:313  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: thiopurine S-methyltransferase
Gene Tree: Tpmt

Human homologs

Human Homolog		TPMT, thiopurine S-methyltransferase
NCBI Gene ID		7172
neXtProt AC		NX_P51580
Human Chr (Location)		6p22.3; chr6:18128542-18155374 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TPMT

Alleles and phenotypes

All alleles(10) : Targeted(3) Gene trapped(7)
 

Homozygous and heterozygous mutation of this gene results in increased sensitivity to mercaptopurine.

 
Human Diseases Modeled Using Mouse Tpmt (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	methylation
Component	cytoplasm
Function	methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (98)    Tissues (95)    Images (4)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	98

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(35) cDNA(34) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000024764 (Evidence)
Ensembl Gene Model	ENSMUSG00000021376 (Evidence)
Entrez Gene	22017 (Evidence)
UniGene	10169
DFCI	TC1582849, TC1600751
DoTS	DT.101366425, DT.487113, DT.55275414, DT.94232342
NIA Mouse Gene Index	U034740
EC	2.1.1.67
PDB	3BGD, 3BGI, 2GB4
Consensus CDS Project	CCDS26488.1
International Mouse Knockout Project Status	Tpmt

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024764	VEGA Gene Model | MGI Sequence Detail	19568	C57BL/6J
transcript	OTTMUST00000060976	VEGA | MGI Sequence Detail	1081	Not Applicable
polypeptide	OTTMUSP00000029822	VEGA | MGI Sequence Detail	240	Not Applicable

All sequences(52) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(102 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025835	Thiopurine S-methyltransferase
InterPro	IPR008854	TPMT family
Protein Ontology	PR:000016583	thiopurine S-methyltransferase

References

(Earliest) J:8633 Otterness DM, et al., Mouse thiopurine methyltransferase pharmacogenetics: monogenic inheritance. J Pharmacol Exp Ther. 1987 Mar;240(3):817-24
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(36)

Other accession IDs

MGD-MRK-15208, MGI:2145410