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Tpmt
Gene Detail
 Symbol
Name
ID
Tpmt
thiopurine methyltransferase
MGI:98812
Feature Type protein coding gene
Genetic Map
Chromosome 13
24.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr13:47025170-47044737 bp, - strand
From VEGA annotation of GRCm38

  19568 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:313  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: thiopurine S-methyltransferase
Gene Tree: Tpmt

Human
homologs
Human Homolog TPMT, thiopurine S-methyltransferase
NCBI Gene ID 7172
neXtProt AC  NX_P51580
Human Chr (Location)  6p22.3; chr6:18128311-18155143 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human TPMT
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(7) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous and heterozygous mutation of this gene results in increased sensitivity to mercaptopurine.
 
Human Diseases Modeled Using Mouse Tpmt (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Tpmt interacts with 113 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process methylation
Component cytoplasm, extracellular vesicular exosome
Function methyltransferase activity, S-adenosylmethionine-dependent methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (98)    Tissues (95)    Images (4)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 98
cDNA source data(33)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(36) cDNA(35) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000024764 (Evidence)
Ensembl Gene ModelENSMUSG00000021376 (Evidence)
Entrez Gene22017 (Evidence)
UniGene10169
DFCITC1582849, TC1600751
DoTSDT.101366425, DT.487113, DT.55275414, DT.94232342
NIA Mouse Gene IndexU034740
EC2.1.1.67
PDB3BGD, 3BGI, 2GB4
Consensus CDS ProjectCCDS26488.1
International Mouse Knockout Project StatusTpmt
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024764 VEGA Gene Model | MGI Sequence Detail 19568 C57BL/6J ±  kb
transcript OTTMUST00000060976 VEGA | MGI Sequence Detail 1081 Not Applicable 
polypeptide OTTMUSP00000029822 VEGA | MGI Sequence Detail 240 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(6) UniProt(6)
Polymorphisms SNPs within 2kb(174 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025835 Thiopurine S-methyltransferase
InterPro IPR008854 TPMT family
Protein Ontology PR:000016583 thiopurine S-methyltransferase
References (Earliest) J:8633 Otterness DM, et al., Mouse thiopurine methyltransferase pharmacogenetics: monogenic inheritance. J Pharmacol Exp Ther. 1987 Mar;240(3):817-24
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(37)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15208, MGI:2145410

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory