Tg
Gene Detail

Symbol

Name
ID

Tg
thyroglobulin
MGI:98733

Synonyms

Tgn

Feature Type

protein coding gene

Genetic Map

Chromosome 15
29.30 cM, cytoband D3-E
Detailed Genetic Map ± 1 cM


Mapping data(42)

Sequence Map

Chr15:66670753-66850721 bp, + strand From VEGA annotation of GRCm38   179969 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:2430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: thyroglobulin
Gene Tree: Tg

Human
homologs

Human Homolog		TG, thyroglobulin
NCBI Gene ID		7038
neXtProt AC		NX_P01266
Human Synonyms		AITD3, TGN
Human Chr (Location)		8q24; chr8:132866916-133134902 (+)  GRCh38
Disease Associations		(2) Diseases Associated with Human TG

Mutations,
alleles, and
phenotypes

All mutations/alleles(4) : Gene trapped(1) Radiation induced(1) Spontaneous(1) Targeted(1)
Genomic Mutations involving Tg (1)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for a spontaneous mutation exhibit enlarged thyroid gland, hypothyroidism, abnormal thyroid gland morphology, and decreased body weight.

 
Human Diseases Modeled in Mice Using Tg (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)

Interactions

Tg interacts with 418 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (21 annotations)

Process	hormone biosynthetic process, iodide transport, ...
Component	endoplasmic reticulum, extracellular region, ...
Function	anion binding, carboxylic ester hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (31 records)

Data Summary: Results (39)    Tissues (16)    Images (11)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	12
RNA in situ	19
RT-PCR	8

cDNA source data(341)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(347) cDNA(345) Primer pair(1) Other(1)
Microarray probesets(3)

Other database
links

VEGA Gene Model	OTTMUSG00000035631 (Evidence)
Ensembl Gene Model	ENSMUSG00000053469 (Evidence)
Entrez Gene	21819 (Evidence)
UniGene	441333
DFCI	TC1572647
DoTS	DT.101294005, DT.102535635
NIA Mouse Gene Index	U016305
Consensus CDS Project	CCDS37091.1
International Mouse Knockout Project Status	Tg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035631	VEGA Gene Model | MGI Sequence Detail	179969	C57BL/6J
transcript	OTTMUST00000091186	VEGA | MGI Sequence Detail	8454	Not Applicable
polypeptide	OTTMUSP00000050192	VEGA | MGI Sequence Detail	2766	Not Applicable

All sequences(50) RefSeq(6) UniProt(5)

Polymorphisms

RFLP(7) : SNPs within 2kb(1650 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR002018	Carboxylesterase, type B
InterPro	IPR019819	Carboxylesterase type B, conserved site
InterPro	IPR016324	Thyroglobulin
InterPro	IPR000716	Thyroglobulin type-1
InterPro	IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like
Protein Ontology	PR:000016283	thyroglobulin

References

(Earliest) J:13923 Beamer WG, et al., [Adipose storage deficiency (asd)]. Mouse News Lett. 1982;67:21
(Latest) J:201463 Watson LA, et al., Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest. 2013 May 1;123(5):2049-63
All references(97)
Disease annotation references (1)

Other
accession IDs

MGD-MRK-15075, MGD-MRK-2049, MGI:88444