Tg MGI Mouse Gene Detail - MGI:98733

Tg Gene Detail

Symbol

Tg
Name

thyroglobulin
Synonyms

Tgn

Feature Type

protein coding gene
IDs

MGI:98733
NCBI Gene: 21819
Gene Overview

MyGene.info: TG
Alliance

gene page

Sequence Map

Chr15:66670753-66850721 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

179969 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 29.30 cM, cytoband D3-E
Mapping Data

42 experiments

Human Ortholog

TG, thyroglobulin

Vertebrate Orthologs

10

Human Ortholog

TG, thyroglobulin
Orthology source: HomoloGene, HGNC
Synonyms

AITD3, TGN
Links

HGNC:11764

NCBI Gene ID: 7038

neXtProt AC: NX_P01266

UniProt: P01266
Chr Location

8q24.22; chr8:132866943-133134902 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 2430
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: TG
Protein SuperFamily

thyroglobulin
Gene Tree

Tg

Diseases

1 with Tg mouse models

Human Disease

Mouse Models

congenital hypothyroidism

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

20 phenotypes from 5 alleles in 6 genetic backgrounds
1 images
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (ENU)

3
Chemically induced (other)

3
Gene trapped

1
Radiation induced

2
Spontaneous

1
Targeted

1
Transgenic

1
Genomic Mutations

5 involving Tg
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

87 strains or lines available

Mice homozygous for a spontaneous mutation exhibit enlarged thyroid gland, hypothyroidism, abnormal thyroid gland morphology, and decreased body weight.

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All GO Annotations

20
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

47
Tissues

16
cDNA Data

341
Literature Summary

36

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN tg

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Tg interacts with 417 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

44
RefSeq

4
UniProt

5
CCDS

CCDS37091.1
UniGene

441333

			Length	Strain/Species	Flank
genomic	OTTMUSG00000035631	VEGA Gene Model \| MGI Sequence Detail	179969	C57BL/6J	± kb
transcript	OTTMUST00000091186	VEGA \| MGI Sequence Detail	8454	Not Applicable
polypeptide	OTTMUSP00000050192	VEGA \| MGI Sequence Detail	2766	Not Applicable

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SNPs within 2kb

1648 from dbSNP Build 142

RFLP

7

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UniProt

5 Sequences
Protein Ontology

PR:000016283 thyroglobulin

(term hierarchy)
InterPro Domains

IPR029058 Alpha/Beta hydrolase fold

IPR002018 Carboxylesterase, type B

IPR019819 Carboxylesterase type B, conserved site

IPR016324 Thyroglobulin

IPR000716 Thyroglobulin type-1

IPR036857 Thyroglobulin type-1 superfamily

IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like

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All nucleic 348

cDNA 345

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-15075, MGD-MRK-2049, MGI:88444

Summaries

All 125

Developmental Gene Expression 36

Diseases 2

Gene Ontology 6

Phenotypes 38
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:235682 Villacorte M, et al., Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly. Development. 2016 Jun 1;143(11):1958-70

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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