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Tg
Gene Detail
Symbol

Name
ID
Tg
thyroglobulin
MGI:98733
Synonyms
Tgn
Feature Type
protein coding gene
Genetic Map
Chromosome 15
29.30 cM, cytoband D3-E
Detailed Genetic Map ± 1 cM


Mapping data(42)
Sequence Map
Chr15:66670753-66850721 bp, + strand
From VEGA annotation of GRCm38

  179969 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TG
Protein SuperFamily: thyroglobulin
Gene Tree: Tg

Human
homologs
TG, thyroglobulin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7038
neXtProt AC: NX_P01266

Human Synonyms: AITD3, TGN

Human Chr (Location): 8q24; chr8:132866935-133134902 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TG

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Radiation induced(1) Spontaneous(1) Targeted(1)
Genomic Mutations involving Tg (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous mutation exhibit enlarged thyroid gland, hypothyroidism, abnormal thyroid gland morphology, and decreased body weight.
 
Human Diseases Modeled in Mice Using Tg (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Tg interacts with 417 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process hormone biosynthetic process, iodide transport, ...
Component endoplasmic reticulum, extracellular region, ...
Function anion binding, chaperone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (39)    Tissues (16)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 12
RNA in situ 19
RT-PCR 8
cDNA source data(341)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tg ; ZFIN tg    NEW 
Molecular
reagents
All nucleic(347) cDNA(345) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035631 (Evidence)
Ensembl Gene Model ENSMUSG00000053469 (Evidence)
Entrez Gene 21819 (Evidence)
UniGene 441333
DFCI TC1572647
DoTS DT.101294005, DT.102535635
NIA Mouse Gene Index U016305
Consensus CDS Project CCDS37091.1
International Mouse Phenotyping Consortium Status Tg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035631 VEGA Gene Model | MGI Sequence Detail 179969 C57BL/6J ±  kb
transcript OTTMUST00000091186 VEGA | MGI Sequence Detail 8454 Not Applicable 
polypeptide OTTMUSP00000050192 VEGA | MGI Sequence Detail 2766 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(5)
Polymorphisms
RFLP(7) : SNPs within 2kb(1650 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019819 Carboxylesterase type B, conserved site
InterPro IPR016324 Thyroglobulin
InterPro IPR000716 Thyroglobulin type-1
InterPro IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
Protein Ontology PR:000016283 thyroglobulin
References
(Earliest) J:13923 Beamer WG, et al., [Adipose storage deficiency (asd)]. Mouse News Lett. 1982;67:21
(Latest) J:220108 Marotta P, et al., The paired box transcription factor Pax8 is essential for function and survival of adult thyroid cells. Mol Cell Endocrinol. 2014 Oct;396(1-2):26-36
All references(93)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15075, MGD-MRK-2049, MGI:88444

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory