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Tg Gene Detail
Summary
  • Symbol
    Tg
  • Name
    thyroglobulin
  • Synonyms
    Tgn
  • Feature Type
    protein coding gene
  • IDs
    MGI:98733
    NCBI Gene: 21819
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:66542606-66722570 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 29.30 cM, cytoband D3-E
  • Mapping Data
    42 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1625 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98733
 protein coding gene Chr15:66542602-66722570 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021907
 protein coding gene Chr15:66188339-66373767 (+)
A/J MGP_AJ_G0021866
 protein coding gene Chr15:63682255-63863290 (+)
AKR/J MGP_AKRJ_G0021848
 protein coding gene Chr15:65441880-65628205 (+)
BALB/cJ MGP_BALBcJ_G0021873
 protein coding gene Chr15:63859823-64046437 (+)
C3H/HeJ MGP_C3HHeJ_G0021646
 protein coding gene Chr15:65554898-65749614 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022312
 protein coding gene Chr15:68756546-68947409 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019849
 protein coding gene Chr15:60456683-60636851 (+)
CAST/EiJ MGP_CASTEiJ_G0021165
 protein coding gene Chr15:66215937-66406252 (+)
CBA/J MGP_CBAJ_G0021612
 protein coding gene Chr15:71045405-71236824 (+)
DBA/2J MGP_DBA2J_G0021737
 protein coding gene Chr15:63464487-63645304 (+)
FVB/NJ MGP_FVBNJ_G0021719
 protein coding gene Chr15:62498635-62682708 (+)
LP/J MGP_LPJ_G0021809
 protein coding gene Chr15:66080529-66267368 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021742
 protein coding gene Chr15:76144047-76335298 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022334
 protein coding gene Chr15:65814517-66003148 (+)
PWK/PhJ MGP_PWKPhJ_G0020906
 protein coding gene Chr15:63558938-63739669 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020747
 protein coding gene Chr15:65680113-65866151 (+)
WSB/EiJ MGP_WSBEiJ_G0021217
 protein coding gene Chr15:65788622-65971717 (+)



Homology
more
  • Human Ortholog
    TG, thyroglobulin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TG, thyroglobulin
  • Synonyms
    AITD3, TGN
  • Links
    NCBI Gene ID: 7038
    neXtProt AC: NX_P01266
    UniProt: P01266

  • Chr Location
    8q24.22; chr8:132866943-133134902 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Tg mouse models; 4 with human TG associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 10 alleles in 12 genetic backgrounds
    1 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a spontaneous mutation exhibit enlarged and abnormal thyroid gland, hypothyroidism, and decreased body weight with altered lymphotcyte numbers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    767
  • Tissues
    23
  • cDNA Data
    342
  • Literature Summary
    43
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21819 NCBI Gene Model | MGI Sequence Detail 179965 C57BL/6J ±  kb
    transcript NM_009375 RefSeq | MGI Sequence Detail 8462 Not Specified  
    polypeptide O08710 UniProt | EBI | MGI Sequence Detail 2766 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 350
      cDNA 347
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15075, MGD-MRK-2049, MGI:88444
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 43
      Diseases 2
      Gene Ontology 10
      Phenotypes 47
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:317410 Johansson E, et al., Asynchrony of Apical Polarization, Luminogenesis, and Functional Differentiation in the Developing Thyroid Gland. Front Endocrinol (Lausanne). 2021;12:760541
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    08/03/2022
    MGI 6.21     		The Jackson Laboratory