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Tg Gene Detail
Summary
  • Symbol
    Tg
  • Name
    thyroglobulin
  • Synonyms
    Tgn
  • Feature Type
    protein coding gene
  • IDs
    MGI:98733
    NCBI Gene: 21819
  • Gene Overview
    MyGene.info: TG
Location & Maps
more
  • Sequence Map
    Chr15:66670753-66850721 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      179969 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 29.30 cM, cytoband D3-E
  • Mapping Data
    42 experiments
Homology
more
  • Human Ortholog
    TG, thyroglobulin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TG, thyroglobulin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AITD3, TGN
  • Links
    NCBI Gene ID: 7038
    neXtProt AC: NX_P01266
    UniProt: P01266

  • Chr Location
    8q24.22; chr8:132866943-133134902 (+)  GRCh38.p7
  • HomoloGene
    Vertebrate Homology Class 2430
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TG
  • Protein SuperFamily
    thyroglobulin
  • Gene Tree
    Tg
Human Diseases
more
  • Diseases
    1 with Tg mouse models; 1 with human TG associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 5 alleles in 6 genetic backgrounds
    1 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (ENU)
    3
  • Chemically induced (other)
    3
  • Gene trapped
    1
  • Radiation induced
    2
  • Spontaneous
    1
  • Targeted
    1
  • Transgenic
    1
  • Genomic Mutations
    5 involving Tg
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    66 strains or lines available
Mice homozygous for a spontaneous mutation exhibit enlarged thyroid gland, hypothyroidism, abnormal thyroid gland morphology, and decreased body weight.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    40
  • Tissues
    16
  • cDNA Data
    341
  • Literature Summary
    35
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035631 VEGA Gene Model | MGI Sequence Detail 179969 C57BL/6J ±  kb
transcript OTTMUST00000091186 VEGA | MGI Sequence Detail 8454 Not Applicable  
polypeptide OTTMUSP00000050192 VEGA | MGI Sequence Detail 2766 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    1648 from dbSNP Build 142
  • RFLP
    7
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 347
    cDNA 345
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15075, MGD-MRK-2049, MGI:88444
References
more
  • Summaries
    All 121
    Developmental Gene Expression 35
    Diseases 2
    Gene Ontology 6
    Phenotypes 38
  • Earliest
    J:13437 Bangham JW, Hairy ears, Eh. Mouse News Lett. 1965;33:68
  • Latest
    J:235682 Villacorte M, et al., Thyroid follicle development requires Smad1/5- and endothelial cell-dependent basement membrane assembly. Development. 2016 Jun 1;143(11):1958-70
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
05/16/2017
MGI 6.09 		The Jackson Laboratory