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Tg
Gene Detail
 Symbol
Name
ID
Tg
thyroglobulin
MGI:98733
Synonyms Tgn
Feature Type protein coding gene
Genetic Map
Chromosome 15
29.30 cM, cytoband D3-E
Detailed Genetic Map ± 1 cM


Mapping data(42)
Sequence Map
Chr15:66670753-66850721 bp, + strand
From VEGA annotation of GRCm38

  179969 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: thyroglobulin
Gene Tree: Tg

Human
homologs
Human Homolog TG, thyroglobulin
NCBI Gene ID 7038
neXtProt AC  NX_P01266
Human Synonyms  AITD3, TGN
Human Chr (Location)  8q24; chr8:132866916-133134902 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TG
Alleles
and
phenotypes
All alleles(3) : Gene trapped(1) Spontaneous(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a spontaneous mutation exhibit enlarged thyroid gland, hypothyroidism, abnormal thyroid gland morphology, and decreased body weight.
 
Human Diseases Modeled Using Mouse Tg (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process hormone biosynthetic process, iodide transport, ...
Component endoplasmic reticulum, extracellular region, ...
Function anion binding, chaperone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (39)    Tissues (15)    Images (11)
Theiler Stages: 20, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 19
RT-PCR 8
cDNA source data(341)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(347) cDNA(345) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035631 (Evidence)
Ensembl Gene ModelENSMUSG00000053469 (Evidence)
Entrez Gene21819 (Evidence)
UniGene441333
DFCITC1572647
DoTSDT.101294005, DT.102535635
NIA Mouse Gene IndexU016305
Consensus CDS ProjectCCDS37091.1
International Mouse Knockout Project StatusTg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035631 VEGA Gene Model | MGI Sequence Detail 179969 C57BL/6J ±  kb
transcript OTTMUST00000091186 VEGA | MGI Sequence Detail 8454 Not Applicable 
polypeptide OTTMUSP00000050192 VEGA | MGI Sequence Detail 2766 Not Applicable 

For the selected sequences
All sequences(50) RefSeq(6) UniProt(5)
Polymorphisms RFLP(7) : SNPs within 2kb(1650 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002018 Carboxylesterase, type B
InterPro IPR019819 Carboxylesterase type B, conserved site
InterPro IPR016324 Thyroglobulin
InterPro IPR000716 Thyroglobulin type-1
InterPro IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
Protein Ontology PR:000016283 thyroglobulin
References (Earliest) J:13923 Beamer WG, et al., [Adipose storage deficiency (asd)]. Mouse News Lett. 1982;67:21
(Latest) J:201463 Watson LA, et al., Atrx deficiency induces telomere dysfunction, endocrine defects, and reduced life span. J Clin Invest. 2013 May 1;123(5):2049-63
All references(97)
Other
accession IDs
MGD-MRK-15075, MGD-MRK-2049, MGI:88444

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory