Tec
Gene Detail

Symbol Name ID

Tec tec protein tyrosine kinase MGI:98662

Feature Type

protein coding gene

Genetic Map

Chromosome 5

38.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr5:72755718-72868483 bp, - strand From VEGA annotation of GRCm38   112766 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Tec ± 2 cM)

Protein SuperFamily: tyrosine-protein kinase, TEC type
Gene Tree: Tec

Human ortholog

TEC tec protein tyrosine kinase NCBI Gene ID 7006
Human Synonyms: PSCTK4
Human Chr4:48137800-48271814 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Mice homozygous for a knock-out allele exhibit a minor reduction in platetet aggregation in response to threshold concentrations of collagen-related peptide or collagen.

 
Human Diseases Modeled Using Mouse Tec (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	B cell receptor signaling pathway, integrin-mediated signaling pathway, ...
Component	cytoplasm, cytoskeleton, ...
Function	ATP binding, kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (93)    Tissues (44)    Images (13)
Theiler Stages: 13, 17, 19, 23, 24, 28

Assay Type	Results
RNA in situ	46
RNase protection	47

cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(59) Genomic(2) cDNA(52) Primer pair(1) Other(4)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000025011 (Evidence)
Ensembl Gene Model	ENSMUSG00000029217 (Evidence)
Entrez Gene	21682 (Evidence)
UniGene	319581
DFCI	TC1579177, TC1591839, TC1592566, TC1672147
DoTS	DT.101137569, DT.101302026, DT.101377735, DT.101725013, DT.110648639, DT.529331, DT.91327773, DT.99840872
EC	2.7.10.2
PDB	1GL5
Consensus CDS Project	CCDS51515.1, CCDS51516.1
International Mouse Knockout Project Status	Tec

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025011	VEGA Gene Model | MGI Sequence Detail	112766	C57BL/6J
transcript	OTTMUST00000061564	VEGA | MGI Sequence Detail	2665	Not Applicable
polypeptide	OTTMUSP00000030213	VEGA | MGI Sequence Detail	630	Not Applicable

All sequences(85) RefSeq(7) UniProt(7)

Polymorphisms

RFLP(3) : SNPs(879 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR001562	Zinc finger, Btk motif
Protein Ontology	PR:000002240	tyrosine-protein kinase Tec

References

(Earliest) J:22689 Wilks AF, et al., The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989 Dec 21;85(1):67-74
(Latest) J:174854 Ormsby T, et al., Btk is a positive regulator in the TREM-1/DAP12 signaling pathway. Blood. 2011 Jul 28;118(4):936-45
All references(61)

Other accession IDs

MGD-MRK-14989