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Tec
Gene Detail
Symbol

Name
ID
Tec
tec protein tyrosine kinase
MGI:98662
Feature Type
protein coding gene
Genetic Map
Chromosome 5
38.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr5:72755716-72868483 bp, - strand
From VEGA annotation of GRCm38

  112768 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1302  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TEC
Protein SuperFamily: tyrosine-protein kinase, TEC type
Gene Tree: Tec

Human
homologs
TEC, tec protein tyrosine kinase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7006
neXtProt AC: NX_P42680

Human Synonyms: PSCTK4

Human Chr (Location): 4p12; chr4:48135783-48269797 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Radiation induced(1) Targeted(3)
Genomic Mutations involving Tec (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit a minor reduction in platetet aggregation in response to threshold concentrations of collagen-related peptide or collagen.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(4)
Interactions
Tec interacts with 290 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process adaptive immune response, B cell receptor signaling pathway, ...
Component cell-cell junction, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (93)    Tissues (44)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 46
RNase protection 47
cDNA source data(51)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tec    NEW 
Molecular
reagents
All nucleic(58) Genomic(2) cDNA(51) Primer pair(1) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000025011 (Evidence)
Ensembl Gene Model ENSMUSG00000029217 (Evidence)
Entrez Gene 21682 (Evidence)
UniGene 319581
DFCI TC1579177, TC1591839, TC1592566, TC1672147
DoTS DT.101137569, DT.101302026, DT.101377735, DT.101725013, DT.110648639, DT.529331, DT.91327773, DT.99840872
EC 2.7.10.2
PDB 1GL5
Consensus CDS Project CCDS51515.1, CCDS51516.1
International Mouse Phenotyping Consortium Status Tec
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025011 VEGA Gene Model | MGI Sequence Detail 112768 C57BL/6J ±  kb
transcript OTTMUST00000061564 VEGA | MGI Sequence Detail 2659 Not Applicable 
polypeptide OTTMUSP00000030213 VEGA | MGI Sequence Detail 630 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(20) UniProt(7)
Polymorphisms
RFLP(3) : SNPs within 2kb(1097 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 SH3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR001562 Zinc finger, Btk motif
Protein Ontology PR:000002240 tyrosine-protein kinase Tec
References
(Earliest) J:22689 Wilks AF, et al., The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989 Dec 21;85(1):67-74
(Latest) J:222587 Manne BK, et al., Distinct pathways regulate Syk protein activation downstream of immune tyrosine activation motif (ITAM) and hemITAM receptors in platelets. J Biol Chem. 2015 May 1;290(18):11557-68
All references(64)
Other
accession IDs
MGD-MRK-14989

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory