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Tec
Gene Detail
 Symbol
Name
ID
Tec
tec protein tyrosine kinase
MGI:98662
Feature Type protein coding gene
Genetic Map
Chromosome 5
38.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr5:72755718-72868483 bp, - strand
From VEGA annotation of GRCm38

  112766 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1302  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, TEC type
Gene Tree: Tec

Human
homologs
Human Homolog TEC, tec protein tyrosine kinase
NCBI Gene ID 7006
neXtProt AC  NX_P42680
Human Synonyms  PSCTK4
Human Chr (Location)  4p12; chr4:48135783-48269797 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit a minor reduction in platetet aggregation in response to threshold concentrations of collagen-related peptide or collagen.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Tec interacts with 291 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process B cell receptor signaling pathway, immune system process, ...
Component cell-cell junction, cytoplasm, ...
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (93)    Tissues (44)    Images (13)
Theiler Stages: 13, 17, 19, 23, 24, 28
Assay TypeResults
RNA in situ 46
RNase protection 47
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(58) Genomic(2) cDNA(51) Primer pair(1) Other(4)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000025011 (Evidence)
Ensembl Gene ModelENSMUSG00000029217 (Evidence)
Entrez Gene21682 (Evidence)
UniGene319581
DFCITC1579177, TC1591839, TC1592566, TC1672147
DoTSDT.101137569, DT.101302026, DT.101377735, DT.101725013, DT.110648639, DT.529331, DT.91327773, DT.99840872
EC2.7.10.2
PDB1GL5
Consensus CDS ProjectCCDS51515.1, CCDS51516.1
International Mouse Knockout Project StatusTec
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025011 VEGA Gene Model | MGI Sequence Detail 112766 C57BL/6J ±  kb
transcript OTTMUST00000061564 VEGA | MGI Sequence Detail 2665 Not Applicable 
polypeptide OTTMUSP00000030213 VEGA | MGI Sequence Detail 630 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(18) UniProt(7)
Polymorphisms RFLP(3) : SNPs within 2kb(1097 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR001562 Zinc finger, Btk motif
Protein Ontology PR:000002240 tyrosine-protein kinase Tec
References (Earliest) J:22689 Wilks AF, et al., The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989 Dec 21;85(1):67-74
(Latest) J:205441 Liang Y, et al., The lymphoid lineage-specific actin-uncapping protein Rltpr is essential for costimulation via CD28 and the development of regulatory T cells. Nat Immunol. 2013 Aug;14(8):858-66
All references(63)
Other
accession IDs
MGD-MRK-14989

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory