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Tec Gene Detail
Summary
  • Symbol
    Tec
  • Name
    tec protein tyrosine kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:98662
    NCBI Gene: 21682
  • Gene Overview
    MyGene.info: TEC
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:72755716-72868483 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      112768 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 38.44 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    TEC, tec protein tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TEC, tec protein tyrosine kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PSCTK4
  • Links
    NCBI Gene ID: 7006
    neXtProt AC: NX_P42680
    UniProt: P42680

  • Chr Location
    4p12-p11; chr4:48135783-48269864 (-)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotypes from multigenic genotypes
    264 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a minor reduction in platetet aggregation in response to threshold concentrations of collagen-related peptide or collagen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025011 VEGA Gene Model | MGI Sequence Detail 112768 C57BL/6J ±  kb
transcript OTTMUST00000061564 VEGA | MGI Sequence Detail 2659 Not Applicable  
polypeptide OTTMUSP00000030213 VEGA | MGI Sequence Detail 630 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1091 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 59
    Genomic 2
    cDNA 52
    Primer pair 1
    Other 4

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-14989
References
more
  • Summaries
    All 318
    Developmental Gene Expression 9
    Diseases 2
    Gene Ontology 6
    Phenotypes 264
  • Earliest
    J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
  • Latest
    J:263139 Philp AR, et al., Kcnn4 is a modifier gene of intestinal cystic fibrosis preventing lethality in the Cftr-F508del mouse. Sci Rep. 2018 Jun 18;8(1):9320

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory