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Tcf3 Gene Detail
Summary
  • Symbol
    Tcf3
  • Name
    transcription factor 3
  • Synonyms
    A1, ALF2, bHLHb21, E12, E2A, E47, Pan1, Pan2, Tcfe2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:98510
    NCBI Gene: 21423
Location & Maps
more
  • Sequence Map
    Chr10:80409514-80433647 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24134 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TCF3, transcription factor 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TCF3, transcription factor 3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHb21, E2A, E47, ITF1, TCF-3, VDIR
  • Links
    NCBI Gene ID: 6929
    neXtProt AC: NX_P15923

  • Chr Location
    19p13.3; chr19:1609290-1652426 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 20 alleles in 24 genetic backgrounds
    55 phenotypes from multigenic genotypes
    84 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    65
  • Chemically induced (other)
    1
  • Gene trapped
    37
  • Targeted
    23
  • Transgenic
    4
  • Genomic Mutations
    1 involving Tcf3
  • Incidental Mutations
Homozygotes for targeted null mutations are devoid of mature B cells, have a partial early block in T-lymphocyte development, and show high postnatal mortality. Many survivors develop T-cell lymphomas between 3 and 10 months of age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019126 VEGA Gene Model | MGI Sequence Detail 24134 C57BL/6J ±  kb
transcript OTTMUST00000045822 VEGA | MGI Sequence Detail 2928 Not Applicable  
polypeptide OTTMUSP00000020640 VEGA | MGI Sequence Detail 653 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    56 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    12 Sequences
  • PDB
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Molecular
Reagents
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  • All nucleic 156
    Genomic 2
    cDNA 148
    Primer pair 5
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-14762, MGI:2143467, MGI:2143825
References
more
  • Summaries
    All 200
    Developmental Gene Expression 24
    Diseases 1
    Gene Ontology 48
    Phenotypes 84
  • Earliest
    J:48121 Murre C, et al., Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell. 1989 Aug 11;58(3):537-44
  • Latest
    J:226241 Duque-Afonso J, et al., Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia. J Clin Invest. 2015 Sep;125(9):3667-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory