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Tcf3
Gene Detail
 Symbol
Name
ID
Tcf3
transcription factor 3
MGI:98510
Synonyms A1, ALF2, bHLHb21, E12, E2A, E47, Pan1, Pan2, Tcfe2a
Feature Type protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:80409514-80433647 bp, - strand
From VEGA annotation of GRCm38

  24134 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2408  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: transcription factor 3
Gene Tree: Tcf3

Human
homologs
Human Homolog TCF3, transcription factor 3
NCBI Gene ID 6929
neXtProt AC  NX_P15923
Human Synonyms  bHLHb21, E2A, E47, ITF1, TCF-3, VDIR
Human Chr (Location)  19p13.3; chr19:1609290-1652334 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(60) : Gene trapped(37) Targeted(23)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations are devoid of mature B cells, have a partial early block in T-lymphocyte development, and show high postnatal mortality. Many survivors develop T-cell lymphomas between 3 and 10 months of age.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Tcf3 interacts with 101 markers (Mir98, Mir124a-1, Mir124a-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (106 annotations)
Process B cell lineage commitment, cell development, ...
Component cytoplasm, nuclear chromatin, ...
Function bHLH transcription factor binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (120)    Tissues (91)    Images (14)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 74
Northern blot 27
RT-PCR 19
cDNA source data(146)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(156) Genomic(2) cDNA(148) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000019126 (Evidence)
Ensembl Gene ModelENSMUSG00000020167 (Evidence)
Entrez Gene21423 (Evidence)
UniGene3406
DFCITC1572568, TC1587680
DoTSDT.101160919, DT.101166896, DT.110602888, DT.492901, DT.94373614, DT.97343385
NIA Mouse Gene IndexU032010
PDB2QL2
Consensus CDS ProjectCCDS24022.1, CCDS48630.1, CCDS48631.1, CCDS48632.1, CCDS48633.1, CCDS48634.1, CCDS48635.1, CCDS48636.1
International Mouse Knockout Project StatusTcf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019126 VEGA Gene Model | MGI Sequence Detail 24134 C57BL/6J ±  kb
transcript OTTMUST00000045822 VEGA | MGI Sequence Detail 2928 Not Applicable 
polypeptide OTTMUSP00000020640 VEGA | MGI Sequence Detail 653 Not Applicable 

For the selected sequences
All sequences(122) RefSeq(16) UniProt(10)
Polymorphisms All PCR and RFLP(17) : PCR(1) RFLP(16) SNPs within 2kb(56 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000001943 transcription factor E2-alpha
References (Earliest) J:48121 Murre C, et al., Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell. 1989 Aug 11;58(3):537-44
(Latest) J:209824 D'Cruz LM, et al., E and Id proteins influence invariant NKT cell sublineage differentiation and proliferation. J Immunol. 2014 Mar 1;192(5):2227-36
All references(196)
Other
accession IDs
MGD-MRK-14762, MGI:2143467, MGI:2143825

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory