Tcf3
Gene Detail

Symbol Name ID

Tcf3 transcription factor 3 MGI:98510

Synonyms

A1, ALF2, bHLHb21, E12, E2A, E47, Pan1, Pan2, Tcfe2a

Feature Type

protein coding gene

Genetic Map

Chromosome 10

39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:80409514-80433647 bp, - strand From VEGA annotation of GRCm38   24134 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2408  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: transcription factor 3
Gene Tree: Tcf3

Human homologs

Human Homolog		TCF3, transcription factor 3
NCBI Gene ID		6929
neXtProt AC		NX_P15923
Human Synonyms		bHLHb21, E2A, E47, ITF1, TCF-3, VDIR
Human Chr (Location)		19p13.3; chr19:1609289-1652328 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(60) : Targeted(23) Gene trapped(37)
 

Homozygotes for targeted null mutations are devoid of mature B cells, have a partial early block in T-lymphocyte development, and show high postnatal mortality. Many survivors develop T-cell lymphomas between 3 and 10 months of age.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (93 annotations)

Process	B cell lineage commitment, cell development, ...
Component	cytoplasm, nuclear nucleosome, ...
Function	bHLH transcription factor binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (117)    Tissues (84)    Images (12)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	71
Northern blot	27
RT-PCR	19

cDNA source data(151)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(161) Genomic(2) cDNA(153) Primer pair(5) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000019126 (Evidence)
Ensembl Gene Model	ENSMUSG00000020167 (Evidence)
Entrez Gene	21423 (Evidence)
UniGene	3406
DFCI	TC1572568, TC1587680
DoTS	DT.101160919, DT.101166896, DT.110602888, DT.492901, DT.94373614, DT.97343385
NIA Mouse Gene Index	U032010
PDB	2QL2
Consensus CDS Project	CCDS24022.1, CCDS48630.1, CCDS48631.1, CCDS48632.1, CCDS48633.1, CCDS48634.1, CCDS48635.1, CCDS48636.1
International Mouse Knockout Project Status	Tcf3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000019126	VEGA Gene Model | MGI Sequence Detail	24134	C57BL/6J
transcript	OTTMUST00000045822	VEGA | MGI Sequence Detail	2928	Not Applicable
polypeptide	OTTMUSP00000020640	VEGA | MGI Sequence Detail	653	Not Applicable

All sequences(120) RefSeq(16) UniProt(10)

Polymorphisms

All PCR and RFLP(17) : PCR(1) RFLP(16) SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
Protein Ontology	PR:000001943	transcription factor E2-alpha

References

(Earliest) J:48121 Murre C, et al., Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell. 1989 Aug 11;58(3):537-44
(Latest) J:194759 Xu W, et al., E2A transcription factors limit expression of Gata3 to facilitate T lymphocyte lineage commitment. Blood. 2013 Feb 28;121(9):1534-42
All references(185)

Other accession IDs

MGD-MRK-14762, MGI:2143467, MGI:2143825