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Src
Gene Detail
 Symbol
Name
ID
Src
Rous sarcoma oncogene
MGI:98397
Synonyms pp60c-src
Feature Type protein coding gene
Genetic Map
Chromosome 2
78.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(36)
Sequence Map
Chr2:157418444-157471862 bp, + strand
From VEGA annotation of GRCm38

  53419 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21120  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Src

Human
homologs
Human Homolog SRC, SRC proto-oncogene, non-receptor tyrosine kinase
NCBI Gene ID 6714
neXtProt AC  NX_P12931
Human Synonyms  ASV, c-SRC, p60-Src, SRC1
Human Chr (Location)  20q12-q13; chr20:37344685-37405432 (+)  GRCh38
Alleles
and
phenotypes
All alleles(143) : Gene trapped(137) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit growth retardation, failure of tooth eruption, osteopetrosis with lack of secondary bone resorption, and lethality at 3-4 weeks.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (131 annotations)
Process activation of protein kinase B activity, adherens junction organization, ...
Component caveola, cytoplasm, ...
Function ATP binding, cell adhesion molecule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (31 records)
Data Summary: Results (107)    Tissues (54)    Images (15)
Theiler Stages: 19, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 13
RT-PCR 92
cDNA source data(92)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(105) Genomic(6) cDNA(95) Primer pair(1) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016179 (Evidence)
Ensembl Gene ModelENSMUSG00000027646 (Evidence)
Entrez Gene20779 (Evidence)
UniGene22845
DFCITC1578172, TC1598566
DoTSDT.101359821, DT.101365231, DT.522608
NIA Mouse Gene IndexU002739
EC2.7.10.2
Consensus CDS ProjectCCDS16978.1, CCDS38305.1
International Mouse Knockout Project StatusSrc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016179 VEGA Gene Model | MGI Sequence Detail 53419 C57BL/6J ±  kb
transcript OTTMUST00000042346 VEGA | MGI Sequence Detail 2020 Not Applicable 
polypeptide OTTMUSP00000019028 VEGA | MGI Sequence Detail 541 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(14) UniProt(3)
Polymorphisms RFLP(12) : SNPs within 2kb(502 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000027234 proto-oncogene tyrosine-protein kinase Src
References (Earliest) J:5972 Collett MS, et al., Protein kinase activity associated with the avian sarcoma virus src gene product. Proc Natl Acad Sci U S A. 1978 Apr;75(4):2021-4
(Latest) J:210629 Valeri N, et al., MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell. 2014 Apr 14;25(4):469-83
All references(267)
Other
accession IDs
MGD-MRK-14556, MGI:2139334

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory