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Src
Gene Detail
Symbol

Name
ID
Src
Rous sarcoma oncogene
MGI:98397
Synonyms
pp60c-src
Feature Type
protein coding gene
Genetic Map
Chromosome 2
78.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(36)
Sequence Map
Chr2:157418444-157471862 bp, + strand
From VEGA annotation of GRCm38

  53419 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21120  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SRC
Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Src

Human
homologs
SRC, SRC proto-oncogene, non-receptor tyrosine kinase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6714
neXtProt AC: NX_P12931

Human Synonyms: ASV, c-SRC, p60-Src, SRC1

Human Chr (Location): 20q12-q13; chr20:37344685-37405432 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(143) : Gene trapped(137) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit growth retardation, failure of tooth eruption, osteopetrosis with lack of secondary bone resorption, and lethality at 3-4 weeks.
 
Phenotype Images(2)
Interactions
Src interacts with 222 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (169 annotations)
Process activation of protein kinase B activity, adherens junction organization, ...
Component actin filament, caveola, ...
Function ATP binding, cell adhesion molecule binding, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (126)    Tissues (69)    Images (17)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 13
Western blot 6
RT-PCR 92
cDNA source data(92)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SRC ; Xenbase src ; ZFIN src    NEW 
Molecular
reagents
All nucleic(105) Genomic(6) cDNA(95) Primer pair(1) Other(3)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016179 (Evidence)
Ensembl Gene Model ENSMUSG00000027646 (Evidence)
Entrez Gene 20779 (Evidence)
UniGene 22845
DFCI TC1578172, TC1598566
DoTS DT.101359821, DT.101365231, DT.522608
NIA Mouse Gene Index U002739
EC 2.7.10.2
Consensus CDS Project CCDS16978.1, CCDS38305.1
International Mouse Phenotyping Consortium Status Src
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016179 VEGA Gene Model | MGI Sequence Detail 53419 C57BL/6J ±  kb
transcript OTTMUST00000042346 VEGA | MGI Sequence Detail 2020 Not Applicable 
polypeptide OTTMUSP00000019028 VEGA | MGI Sequence Detail 541 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(18) UniProt(3)
Polymorphisms
RFLP(12) : SNPs within 2kb(502 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000027234 proto-oncogene tyrosine-protein kinase Src
References
(Earliest) J:5972 Collett MS, et al., Protein kinase activity associated with the avian sarcoma virus src gene product. Proc Natl Acad Sci U S A. 1978 Apr;75(4):2021-4
(Latest) J:218764 Iqbal Hossain M, et al., Dual role of Src kinase in governing neuronal survival. Brain Res. 2015 Jan 12;1594:1-14
All references(285)
Other
accession IDs
MGD-MRK-14556, MGI:2139334

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory