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Src Gene Detail
Summary
  • Symbol
    Src
  • Name
    Rous sarcoma oncogene
  • Synonyms
    pp60c-src
  • Feature Type
    protein coding gene
  • IDs
    MGI:98397
    NCBI Gene: 20779
  • Gene Overview
    MyGene.info: SRC
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr2:157418444-157471862 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      53419 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 78.35 cM
  • Mapping Data
    36 experiments
Homology
more
  • Human Ortholog
    SRC, SRC proto-oncogene, non-receptor tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SRC, SRC proto-oncogene, non-receptor tyrosine kinase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ASV, c-SRC, p60-Src, SRC1, THC6
  • Links
    NCBI Gene ID: 6714
    neXtProt AC: NX_P12931
    UniProt: P12931

  • Chr Location
    20q11.23; chr20:37344685-37405432 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Src mouse models; 1 with human SRC associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    56 phenotypes from 4 alleles in 5 genetic backgrounds
    31 phenotypes from multigenic genotypes
    2 images
    86 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit growth retardation, failure of tooth eruption, osteopetrosis with lack of secondary bone resorption, and lethality at 3-4 weeks.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    192
  • GO References
    59
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    131
  • Tissues
    72
  • cDNA Data
    92
  • Literature Summary
    38
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016179 VEGA Gene Model | MGI Sequence Detail 53419 C57BL/6J ±  kb
    transcript OTTMUST00000042346 VEGA | MGI Sequence Detail 2020 Not Applicable  
    polypeptide OTTMUSP00000019028 VEGA | MGI Sequence Detail 541 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      501 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      Genomic 6
      cDNA 95
      Primer pair 1
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14556, MGI:2139334
    References
    more
    • Summaries
      All 379
      Developmental Gene Expression 38
      Diseases 1
      Gene Ontology 59
      Phenotypes 86
    • Earliest
      J:5972 Collett MS, et al., Protein kinase activity associated with the avian sarcoma virus src gene product. Proc Natl Acad Sci U S A. 1978 Apr;75(4):2021-4
    • Latest
      J:261626 Matsubara T, et al., The Actin-Binding Protein PPP1r18 Regulates Maturation, Actin Organization, and Bone Resorption Activity of Osteoclasts. Mol Cell Biol. 2018 Feb 15;38(4)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory