Src
Gene Detail

Symbol Name ID

Src Rous sarcoma oncogene MGI:98397

Synonyms

pp60c-src

Feature Type

protein coding gene

Genetic Map

Chromosome 2

78.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(36)

Sequence Map

Chr2:157418444-157471862 bp, + strand From VEGA annotation of GRCm38   53419 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21120  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Src

Human homologs

Human Homolog		SRC, SRC proto-oncogene, non-receptor tyrosine kinase
NCBI Gene ID		6714
neXtProt AC		NX_P12931
Human Synonyms		ASV, c-SRC, p60-Src, SRC1
Human Chr (Location)		20q12-q13; chr20:37344685-37405432 (+)  GRCh38

Alleles and phenotypes

All alleles(143) : Gene trapped(137) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for a targeted null mutation exhibit growth retardation, failure of tooth eruption, osteopetrosis with lack of secondary bone resorption, and lethality at 3-4 weeks.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (131 annotations)

Process	activation of protein kinase B activity, adherens junction organization, ...
Component	caveola, cytoplasm, ...
Function	ATP binding, cell adhesion molecule binding, ...

External Resources: FuncBase

Expression

Literature Summary: (31 records)

Data Summary: Results (107)    Tissues (54)    Images (15)
Theiler Stages: 19, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	13
RT-PCR	92

cDNA source data(92)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(105) Genomic(6) cDNA(95) Primer pair(1) Other(3)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016179 (Evidence)
Ensembl Gene Model	ENSMUSG00000027646 (Evidence)
Entrez Gene	20779 (Evidence)
UniGene	22845
DFCI	TC1578172, TC1598566
DoTS	DT.101359821, DT.101365231, DT.522608
NIA Mouse Gene Index	U002739
EC	2.7.10.2
Consensus CDS Project	CCDS16978.1, CCDS38305.1
International Mouse Knockout Project Status	Src

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016179	VEGA Gene Model | MGI Sequence Detail	53419	C57BL/6J
transcript	OTTMUST00000042346	VEGA | MGI Sequence Detail	2020	Not Applicable
polypeptide	OTTMUSP00000019028	VEGA | MGI Sequence Detail	541	Not Applicable

All sequences(74) RefSeq(14) UniProt(3)

Polymorphisms

RFLP(12) : SNPs within 2kb(502 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR000980	SH2 domain
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
Protein Ontology	PR:000027234	proto-oncogene tyrosine-protein kinase Src

References

(Earliest) J:5972 Collett MS, et al., Protein kinase activity associated with the avian sarcoma virus src gene product. Proc Natl Acad Sci U S A. 1978 Apr;75(4):2021-4
(Latest) J:210629 Valeri N, et al., MicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer. Cancer Cell. 2014 Apr 14;25(4):469-83
All references(267)

Other accession IDs

MGD-MRK-14556, MGI:2139334