Src MGI Mouse Gene Detail - MGI:98397

Src Gene Detail

Symbol

Src
Name

Rous sarcoma oncogene
Synonyms

pp60c-src

Feature Type

protein coding gene
IDs

MGI:98397
NCBI Gene: 20779
Gene Overview

MyGene.info: SRC

Sequence Map

Chr2:157418444-157471862 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

53419 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 78.35 cM
Mapping Data

36 experiments

Human Ortholog

SRC, SRC proto-oncogene, non-receptor tyrosine kinase

Vertebrate Orthologs

10

Human Ortholog

SRC, SRC proto-oncogene, non-receptor tyrosine kinase
Orthology source: HomoloGene, HGNC
Synonyms

ASV, c-SRC, p60-Src, SRC1, THC6
Links

HGNC:11283

NCBI Gene ID: 6714

neXtProt AC: NX_P12931

UniProt: P12931
Chr Location

20q11.23; chr20:37344685-37405432 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 21120
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: SRC
Protein SuperFamily

tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree

Src

Diseases

1 with human SRC associations

				Human Disease	Mouse Models
				colorectal cancer IDs colorectal cancer DOID:9256 KEGG:05210 MESH:D015179 OMIM:114500 OMIM:608812 OMIM:611469 OMIM:612229 OMIM:612230 OMIM:612231 OMIM:612232 OMIM:612589 OMIM:612590 OMIM:612591 OMIM:612592 OMIM:615083 UMLS_CUI:C1527249

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

35 phenotypes from 3 alleles in 4 genetic backgrounds
31 phenotypes from multigenic genotypes
2 images
82 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

145
Gene trapped

137
Targeted

6
Transgenic

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

132 strains or lines available

Homozygotes for a targeted null mutation exhibit growth retardation, failure of tooth eruption, osteopetrosis with lack of secondary bone resorption, and lethality at 3-4 weeks.

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All GO Annotations

187
GO References

56

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

126
Tissues

69
cDNA Data

92
Literature Summary

36

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA SRC

ZFIN src

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Src interacts with 222 markers (Mir1a-1, Mir1a-2, Mir7-1, ...) View All

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All Sequences

73
RefSeq

16
UniProt

4
CCDS

CCDS16978.1, CCDS38305.1
UniGene

22845

			Length	Strain/Species	Flank
genomic	OTTMUSG00000016179	VEGA Gene Model \| MGI Sequence Detail	53419	C57BL/6J	± kb
transcript	OTTMUST00000042346	VEGA \| MGI Sequence Detail	2020	Not Applicable
polypeptide	OTTMUSP00000019028	VEGA \| MGI Sequence Detail	541	Not Applicable

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SNPs within 2kb

501 from dbSNP Build 142

RFLP

12

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UniProt

4 Sequences
Protein Ontology

PR:000027234 proto-oncogene tyrosine-protein kinase Src

(term hierarchy)
EC

2.7.10.2
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR001452 SH3 domain

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

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All nucleic 105

Genomic 6

cDNA 95

Primer pair 1

Other 3

Microarray probesets 4

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MGD-MRK-14556, MGI:2139334

Summaries

All 306

Developmental Gene Expression 36

Gene Ontology 56

Phenotypes 82
Earliest

J:5972 Collett MS, et al., Protein kinase activity associated with the avian sarcoma virus src gene product. Proc Natl Acad Sci U S A. 1978 Apr;75(4):2021-4
Latest

J:243445 Zhang J, et al., c-Src phosphorylation and activation of hexokinase promotes tumorigenesis and metastasis. Nat Commun. 2017 Jan 05;8:13732

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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