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Serpina3k
Gene Detail
 Symbol
Name
ID
Serpina3k
serine (or cysteine) peptidase inhibitor, clade A, member 3K
MGI:98377
Synonyms 1300001I07Rik, alpha-1 antiproteinase, contrapsin, D12Rp54, MMCM2, MMSpi2, RP54, Spi2, Spi-2
Feature Type protein coding gene
Genetic Map
Chromosome 12
53.99 cM, cytoband F1
Detailed Genetic Map ± 1 cM


Mapping data(12)
Sequence Map
Chr12:104338486-104346144 bp, + strand
From VEGA annotation of GRCm38

  7659 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:111129  Vertebrate Homology Class
1 human; 4 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 6 cattle; 1 dog

Protein SuperFamily: serpin
Gene Tree: Serpina3k

Human
homologs
Human Homolog SERPINA3, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
NCBI Gene ID 12
neXtProt AC  NX_P01011
Human Synonyms  AACT, ACT, GIG25
Human Chr (Location)  14q32.1; chr14:94612377-94624053 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Serpina3k interacts with 36 markers (Mir1b, Mir27b, Mir96, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component blood microparticle, extracellular region, ...
Function peptidase inhibitor activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (50)    Tissues (11)    Images (20)
Theiler Stages: 23, 26, 27, 28
Assay TypeResults
RNA in situ 36
Northern blot 14
cDNA source data(511)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(515) Genomic(1) cDNA(513) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000035427 (Evidence)
Ensembl Gene ModelENSMUSG00000058207 (Evidence)
Entrez Gene20714 (Evidence)
UniGene291569
DoTSDT.101318263, DT.101407741, DT.40150689
Consensus CDS ProjectCCDS36537.1
International Mouse Knockout Project StatusSerpina3k
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035427 VEGA Gene Model | MGI Sequence Detail 7659 C57BL/6J ±  kb
transcript OTTMUST00000090585 VEGA | MGI Sequence Detail 2057 Not Applicable 
polypeptide OTTMUSP00000049729 VEGA | MGI Sequence Detail 418 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(1)
Polymorphisms RFLP(6) : SNPs within 2kb(227 from dbSNP Build 137)    SNPs within 2kb including multiple locations(231)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Protease inhibitor I4, serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000015938 serine protease inhibitor A3K
References (Earliest) J:5549 Wilcox FH, Genetic variation in plasma prealbumin of the house mouse. J Hered. 1975 Jan-Feb;66(1):19-22
(Latest) J:193640 Lo JC, et al., RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet. 2012;8(10):e1002969
All references(50)
Other
accession IDs
MGD-MRK-14022, MGD-MRK-14521, MGD-MRK-14526, MGD-MRK-3357, MGI:1915688

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory