Sox9
Gene Detail

Symbol Name ID

Sox9 SRY-box containing gene 9 MGI:98371

Synonyms

2010306G03Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 11

77.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr11:112782224-112787760 bp, + strand From VEGA annotation of GRCm38   5537 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:294  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sox9

Human homologs

Human Homolog		SOX9, SRY (sex determining region Y)-box 9
NCBI Gene ID		6662
neXtProt AC		NX_P48436
Human Synonyms		CMD1, CMPD1, SRA1
Human Chr (Location)		17q23; chr17:70117161-70122561 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SOX9

Alleles and phenotypes

All alleles(14) : Targeted(14)
 

Null mutant heterozygotes and conditional knockout mutants display perinatal lethality with cleft palate, hypoplasia and distortion of numerous cartilage-derived skeletal structures, and premature mineralization in many bones. Specific conditional knockout mutations are sex-reversed.

 
Human Diseases Modeled Using Mouse Sox9 (1)    Alleles Annotated to Human Diseases(4)    Phenotype Images(6)

Gene Ontology (GO) classifications

All GO classifications: (146 annotations)

Process	astrocyte fate commitment, cAMP-mediated signaling, ...
Component	nucleus, protein complex, ...
Function	beta-catenin binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (598 records)
Data Summary: Results (945)    Tissues (435)    Images (240)
Theiler Stages: 5, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	97
RNA in situ	673
Northern blot	9
RT-PCR	163
RNase protection	3

cDNA source data(108)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(146) Genomic(2) cDNA(111) Primer pair(16) Other(17)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000003313 (Evidence)
Ensembl Gene Model	ENSMUSG00000000567 (Evidence)
Entrez Gene	20682 (Evidence)
UniGene	286407
DFCI	TC1574097
DoTS	DT.524924, DT.94207385
NIA Mouse Gene Index	U013510
Consensus CDS Project	CCDS25595.1
International Mouse Knockout Project Status	Sox9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000003313	VEGA Gene Model | MGI Sequence Detail	5537	C57BL/6J
transcript	OTTMUST00000006937	VEGA | MGI Sequence Detail	4135	Not Applicable
polypeptide	OTTMUSP00000003300	VEGA | MGI Sequence Detail	507	Not Applicable

All sequences(71) RefSeq(2) UniProt(23)

Polymorphisms

All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR009071	High mobility group, superfamily
InterPro	IPR022151	Sox developmental protein N-terminal
Protein Ontology	PR:000015435	transcription factor SOX-9

References

(Earliest) J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
(Latest) J:194289 Bell SM, et al., Kruppel-like factor 5 controls villus formation and initiation of cytodifferentiation in the embryonic intestinal epithelium. Dev Biol. 2013 Mar 15;375(2):128-39
All references(710)

Other accession IDs

MGD-MRK-14510, MGI:1917265, MGI:2144464