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Sox9
Gene Detail
Symbol

Name
ID
Sox9
SRY (sex determining region Y)-box 9
MGI:98371
Synonyms
2010306G03Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 11
77.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr11:112782224-112787760 bp, + strand
From VEGA annotation of GRCm38

  5537 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:294  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sox9

Human
homologs
Human Homolog SOX9, SRY (sex determining region Y)-box 9
NCBI Gene ID 6662
neXtProt AC  NX_P48436
Human Synonyms  CMD1, CMPD1, SRA1
Human Chr (Location)  17q24.3; chr17:72121020-72126420 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SOX9
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 
Null mutant heterozygotes and conditional knockout mutants display perinatal lethality with cleft palate, hypoplasia and distortion of numerous cartilage-derived skeletal structures, and premature mineralization in many bones. Specific conditional knockout mutations are sex-reversed.
 
Human Diseases Modeled Using Mouse Sox9 (1)    Alleles Annotated to Human Diseases(4)    Phenotype Images(7)
Interactions
Sox9 interacts with 299 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (220 annotations)
Process astrocyte fate commitment, bronchus cartilage development, ...
Component intracellular, nuclear transcription factor complex, ...
Function beta-catenin binding, bHLH transcription factor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (726 records)
Data Summary: Results (1443)    Tissues (716)    Images (384)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 165
RNA in situ 1049
In situ reporter (knock in) 33
Northern blot 9
RT-PCR 184
RNase protection 3
cDNA source data(114)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(165) Genomic(2) cDNA(117) Primer pair(21) Other(25)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000003313 (Evidence)
Ensembl Gene ModelENSMUSG00000000567 (Evidence)
Entrez Gene20682 (Evidence)
UniGene286407
DFCITC1574097
DoTSDT.524924, DT.94207385
NIA Mouse Gene IndexU013510
Consensus CDS ProjectCCDS25595.1
International Mouse Knockout Project StatusSox9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003313 VEGA Gene Model | MGI Sequence Detail 5537 C57BL/6J ±  kb
transcript OTTMUST00000006937 VEGA | MGI Sequence Detail 4135 Not Applicable 
polypeptide OTTMUSP00000003300 VEGA | MGI Sequence Detail 507 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(2) UniProt(43)
Polymorphisms
All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(45 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009071 High mobility group (HMG) box domain
InterPro IPR022151 Sox developmental protein N-terminal
Protein Ontology PR:000015435 transcription factor SOX-9
References
(Earliest) J:4011 Wright EM, et al., Seven new members of the Sox gene family expressed during mouse development. Nucleic Acids Res. 1993 Feb 11;21(3):744
(Latest) J:214395 Hsu YC, et al., Transit-amplifying cells orchestrate stem cell activity and tissue regeneration. Cell. 2014 May 8;157(4):935-49
All references(855)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-14510, MGI:1917265, MGI:2144464

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory