About   Help   FAQ
Snrpn
Gene Detail
Symbol

Name
ID
Snrpn
small nuclear ribonucleoprotein N
MGI:98347
Synonyms
2410045I01Rik, MGC:18604, MGC:30325, Peg4, Pwcr1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
34.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr7:59982495-60005111 bp, - strand
From VEGA annotation of GRCm38

  22617 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68297  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SNRPN
Protein SuperFamily: small nuclear ribonucleoprotein associated protein, SmB/SmN types
Gene Tree: Snrpn

Human
homologs
SNRPN, small nuclear ribonucleoprotein polypeptide N
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6638
neXtProt AC: NX_P63162

Human Synonyms: HCERN3, PWCR, RT-LI, SM-D, sm-N, SMN, SNRNP-N, SNURF-SNRPN

Human Chr (Location): 15q11.2; chr15:24823647-24978582 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SNRPN

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Targeted(13) Transgenic(1)
Genomic Mutations involving Snrpn (3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted intragenic deletions are phenotypically normal. Deletions that also encompass neighboring genes on the paternal chromosome exhibit growth retardation, hypotonia, and high mortality.
 
Human Diseases Modeled in Mice Using Snrpn (2)    Mutations Annotated to Human Diseases (5)   
Interactions
Snrpn interacts with 141 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process mRNA splicing, via spliceosome
Component catalytic step 2 spliceosome, cytoplasm, ...
Function poly(A) RNA binding, RNA binding
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (259)    Tissues (33)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 221
Northern blot 23
RT-PCR 15
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(31) Genomic(9) cDNA(14) Primer pair(7) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000042349 (Evidence)
Ensembl Gene Model ENSMUSG00000102252 (Evidence)
Entrez Gene 20646 (Evidence)
Consensus CDS Project CCDS39974.1
International Mouse Phenotyping Consortium Status Snrpn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000042349 VEGA Gene Model | MGI Sequence Detail 22617 C57BL/6J ±  kb
transcript OTTMUST00000111612 VEGA | MGI Sequence Detail 1932 Not Applicable 
polypeptide OTTMUSP00000062525 VEGA | MGI Sequence Detail 240 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(6) UniProt(2)
Polymorphisms
All PCR and RFLP(7) : PCR(1) RFLP(6) SNPs within 2kb(1873 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR010920 Like-Sm (LSM) domain
InterPro IPR001163 Ribonucleoprotein LSM domain
InterPro IPR006649 Ribonucleoprotein LSM domain, eukaryotic/archaea-type
InterPro IPR017131 Small ribonucleoprotein associated, SmB/SmN
Protein Ontology PR:000015349 small nuclear ribonucleoprotein-associated protein N
References
(Earliest) J:2311 Gerrelli D, et al., Cloning and sequencing of a mouse embryonal carcinoma cell mRNA encoding the tissue specific RNA splicing protein SmN. Nucleic Acids Res. 1991 Dec 11;19(23):6642
(Latest) J:217174 Nakagaki A, et al., Imprinting analysis of the mouse chromosome 7C region in DNMT1-null embryos. Gene. 2014 Dec 10;553(1):63-8
All references(118)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-14477, MGI:1923808

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/20/2015
MGI 5.22
The Jackson Laboratory