Sim1
Gene Detail

Symbol Name ID

Sim1 single-minded homolog 1 (Drosophila) MGI:98306

Synonyms

bHLHe14

Feature Type

protein coding gene

Genetic Map

Chromosome 10

24.87 cM, cytoband B3-B4
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr10:50895651-50989152 bp, + strand From NCBI annotation of GRCm38   93502 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3715  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sim1

Human homologs

Human Homolog		SIM1, single-minded homolog 1 (Drosophila)
NCBI Gene ID		6492
neXtProt AC		NX_P81133
Human Synonyms		bHLHe14
Human Chr (Location)		6q16.3-q21; chr6:100836750-100911551 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SIM1

Alleles and phenotypes

All alleles(9) : Targeted(8) Chemically induced(1)
 

Mice homozygous for disruptions of this gene die at birth with abnormalities in the paraventricular and supraoptic nuclei. Heterozygous mutant mice are obese and may also be diabetic, hyperinsulinemic and insulin resistant.

 
Human Diseases Modeled Using Mouse Sim1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	cell differentiation, multicellular organismal development, ...
Component	nucleus
Function	DNA binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (69 records)
Data Summary: Results (330)    Tissues (228)    Images (92)
Theiler Stages: 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	326
In situ reporter (knock in)	4

cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(2) cDNA(18) Primer pair(3) Other(9)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000019913 (Evidence)
Entrez Gene	20464 (Evidence)
UniGene	4774
DFCI	TC1592926, TC1674115
DoTS	DT.521937
NIA Mouse Gene Index	U011496
Consensus CDS Project	CCDS48556.1
International Mouse Knockout Project Status	Sim1

Sequences

Length	Strain/Species
genomic	20464	NCBI Gene Model | MGI Sequence Detail	93502	C57BL/6J
transcript	NM_011376	RefSeq | MGI Sequence Detail	7355	Not Specified
polypeptide	Q61045	UniProt | EBI | MGI Sequence Detail	765	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(314 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
InterPro	IPR001610	PAC motif
InterPro	IPR000014	PAS domain
InterPro	IPR013767	PAS fold
InterPro	IPR013655	PAS fold-3
InterPro	IPR010578	Single-minded, C-terminal
Protein Ontology	PR:000014875	single-minded 1

Graphical View of Protein Domain Structure

References

(Earliest) J:15850 Guillemot F, et al., Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell. 1993 Nov 5;75(3):463-76
(Latest) J:181298 Alvarez-Bolado G, et al., Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions. Neural Dev. 2012;7(1):4
All references(116)

Other accession IDs

MGD-MRK-14414