About   Help   FAQ
Sim1
Gene Detail
 Symbol
Name
ID
Sim1
single-minded homolog 1 (Drosophila)
MGI:98306
Synonyms bHLHe14
Feature Type protein coding gene
Genetic Map
Chromosome 10
24.87 cM, cytoband B3-B4
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:50895651-50989152 bp, + strand
From NCBI annotation of GRCm38

  93502 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3715  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sim1

Human
homologs
Human Homolog SIM1, single-minded family bHLH transcription factor 1
NCBI Gene ID 6492
neXtProt AC  NX_P81133
Human Synonyms  bHLHe14
Human Chr (Location)  6q16.3; chr6:100385015-100464929 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SIM1
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene die at birth with abnormalities in the paraventricular and supraoptic nuclei. Heterozygous mutant mice are obese and may also be diabetic, hyperinsulinemic and insulin resistant.
 
Human Diseases Modeled Using Mouse Sim1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Sim1 interacts with 431 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process cell differentiation, multicellular organismal development, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (70 records)
Data Summary: Results (357)    Tissues (250)    Images (97)
Theiler Stages: 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 353
In situ reporter (knock in) 4
cDNA source data(18)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(2) cDNA(19) Primer pair(3) Other(10)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000019913 (Evidence)
Entrez Gene20464 (Evidence)
UniGene4774
DFCITC1592926, TC1674115
DoTSDT.521937
NIA Mouse Gene IndexU011496
Consensus CDS ProjectCCDS48556.1
International Mouse Knockout Project StatusSim1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20464 NCBI Gene Model | MGI Sequence Detail 93502 C57BL/6J ±  kb
transcript NM_011376 RefSeq | MGI Sequence Detail 7355 Not Specified 
polypeptide Q61045 UniProt | EBI | MGI Sequence Detail 765 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(16) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(560 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR001610 PAC motif
InterPro IPR000014 PAS domain
InterPro IPR013767 PAS fold
InterPro IPR013655 PAS fold-3
InterPro IPR010578 Single-minded, C-terminal
Protein Ontology PR:000014875 single-minded homolog 1
Graphical View of Protein Domain Structure
References (Earliest) J:15850 Guillemot F, et al., Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell. 1993 Nov 5;75(3):463-76
(Latest) J:205554 Pivetta C, et al., Motor-circuit communication matrix from spinal cord to brainstem neurons revealed by developmental origin. Cell. 2014 Jan 30;156(3):537-48
All references(119)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14414

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory