Sim1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Sim1
single-minded family bHLH transcription factor 1
MGI:98306

34 phenotypes from 5 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sim1^Rgsc646/Sim1⁺ involves: C57BL/6JJcl * DBA/2JJcl	hyperglycemia	J:133634
	increased circulating insulin level	J:133634
	increased glycosylated hemoglobin level	J:133634
	increased urine glucose level	J:133634
	insulin resistance	J:133634
	obese	J:133634
Sim1^tm1.1Az/Sim1⁺ involves: 129X1/SvJ * C57BL/6 * FVB	abnormal energy homeostasis	J:95410
	increased body length	J:95410
	increased body weight	J:95410
	increased circulating glucose level	J:95410
	increased circulating insulin level	J:95410
	increased circulating leptin level	J:95410
	increased susceptibility to diet-induced obesity	J:95410
	increased total body fat amount	J:95410
	obese	J:95410
	polyphagia	J:95410
Sim1^tm1.2Az/Sim1^tm1.2Az involves: 129X1/SvJ * C57BL/6 * FVB	no abnormal phenotype detected	J:95410
Sim1^tm1Fan/Sim1⁺ involves: 129/Sv * C57BL/6	abnormal brown adipose tissue morphology	J:70586
	abnormal diencephalon morphology	J:50772
	abnormal glucose homeostasis	J:70586
	abnormal white adipose tissue morphology	J:70586
	increased body length	J:70586
	increased brown adipose tissue amount	J:70586
	increased circulating insulin level	J:70586
	increased susceptibility to weight gain	J:70586
	increased white adipose tissue amount	J:70586
	polyphagia	J:70586
Sim1^tm1Fan/Sim1^tm1Fan involves: 129/Sv * C57BL/6	abnormal diencephalon morphology	J:50772
	abnormal paraventricular hypothalamic nucleus morphology	J:50772
	abnormal pituicyte morphology	J:50772
	abnormal supraoptic nucleus morphology	J:50772
	absent magnocellular neurosecretory cells	J:50772
	neonatal lethality, complete penetrance	J:50772
	pituitary gland hypoplasia	J:50772
Sim1^tm1Fan/Sim1^tm1Fan involves: 129S1/Sv * 129X1/SvJ	abnormal nervous system tract morphology	J:104419
Sim1^tm1Jlmd/Sim1^tm1Jlmd involves: 129S1/Sv * 129X1/SvJ * C57BL/6	abnormal hypothalamus morphology	J:104419, J:120909
	abnormal nervous system tract morphology	J:104419
	abnormal neuronal migration	J:120909
	decreased apoptosis	J:120909
	neonatal lethality	J:104419
	normal nervous system phenotype	J:120909

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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