About   Help   FAQ
St3gal1 Gene Detail
Summary
  • Symbol
    St3gal1
  • Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 1
  • Synonyms
    CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase, Siat4, Siat4a, ST3GalI
  • Feature Type
    protein coding gene
  • IDs
    MGI:98304
    NCBI Gene: 20442
Location & Maps
more
  • Sequence Map
    Chr15:67102875-67113992 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11118 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ST3GAL1, ST3 beta-galactoside alpha-2,3-sialyltransferase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ST3GAL1, ST3 beta-galactoside alpha-2,3-sialyltransferase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Gal-NAc6S, SIAT4A, SIATFL, ST3GalA, ST3GalA.1, ST3GalIA, ST3GalIA,1, ST3O
  • Links
    NCBI Gene ID: 6482
    neXtProt AC: NX_Q11201

  • Chr Location
    8q24.22; chr8:133454848-133572454 (-)  GRCh38.p2

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    30 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    3
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    5 involving St3gal1
  • Incidental Mutations
Homozygous mutation of this gene results in altered terminal glycosylation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000013846 Ensembl Gene Model | MGI Sequence Detail 11118 C57BL/6J ±  kb
transcript ENSMUST00000092640 Ensembl | MGI Sequence Detail 4985 Not Applicable  
polypeptide ENSMUSP00000090307 Ensembl | MGI Sequence Detail 337 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    487 from dbSNP Build 142
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000030971 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
  • EC
  • InterPro Domains
    IPR001675 Glycosyl transferase family 29
    IPR012163 Sialyltransferase
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14411, MGI:2146025
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Diseases 1
    Gene Ontology 7
    Phenotypes 30
  • Earliest
    J:14675 Lee YC, et al., Molecular cloning and expression of Gal beta 1,3GalNAc alpha 2,3-sialyltransferase from mouse brain. Eur J Biochem. 1993 Sep 1;216(2):377-85
  • Latest
    J:217719 Orr SL, et al., A phenotype survey of 36 mutant mouse strains with gene-targeted defects in glycosyltransferases or glycan-binding proteins. Glycobiology. 2013 Mar;23(3):363-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory