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St3gal1 Gene Detail
Summary
  • Symbol
    St3gal1
  • Name
    ST3 beta-galactoside alpha-2,3-sialyltransferase 1
  • Synonyms
    CMP-N-acetylneuraminate: [beta-galactosidase alpha-2,3] sialytransferase, Siat4, Siat4a, ST3GalI
  • Feature Type
    protein coding gene
  • IDs
    MGI:98304
    NCBI Gene: 20442
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:67102875-67176830 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 29.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    487 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98304
protein coding gene Chr15:67102875-67176946 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021911
protein coding gene Chr15:66624858-66659663 (-)
A/J MGP_AJ_G0021870
protein coding gene Chr15:64112034-64138387 (-)
AKR/J MGP_AKRJ_G0021852
protein coding gene Chr15:65875636-65888430 (-)
BALB/cJ MGP_BALBcJ_G0021877
protein coding gene Chr15:64291360-64368886 (-)
C3H/HeJ MGP_C3HHeJ_G0021650
protein coding gene Chr15:66002789-66074515 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022316
protein coding gene Chr15:69208236-69254817 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019853
protein coding gene Chr15:60890765-60943685 (-)
CAST/EiJ MGP_CASTEiJ_G0021169
protein coding gene Chr15:66670065-66705933 (-)
CBA/J MGP_CBAJ_G0021616
protein coding gene Chr15:71495075-71569910 (-)
DBA/2J MGP_DBA2J_G0021741
protein coding gene Chr15:63888242-63963548 (-)
FVB/NJ MGP_FVBNJ_G0021723
protein coding gene Chr15:62927991-63002492 (-)
LP/J MGP_LPJ_G0021813
protein coding gene Chr15:66530392-66600625 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021746
protein coding gene Chr15:76599748-76621736 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022338
protein coding gene Chr15:66262839-66288781 (-)
PWK/PhJ MGP_PWKPhJ_G0020910
protein coding gene Chr15:63991775-64014375 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020751
protein coding gene Chr15:66124309-66197593 (-)
WSB/EiJ MGP_WSBEiJ_G0021221
protein coding gene Chr15:66231953-66255525 (-)



Homology
more
  • Human Ortholog
    ST3GAL1, ST3 beta-galactoside alpha-2,3-sialyltransferase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ST3GAL1, ST3 beta-galactoside alpha-2,3-sialyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Gal-NAc6S, SIAT4A, SIATFL, ST3GalA, ST3GalA.1, ST3GalIA, ST3GalIA,1, ST3O
  • Links
    NCBI Gene ID: 6482
    neXtProt AC: NX_Q11201
    UniProt: Q11201

  • Chr Location
    8q24.22; chr8:133454848-133572454 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    31 phenotype references
Homozygous mutation of this gene results in altered terminal glycosylation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000013846 Ensembl Gene Model | MGI Sequence Detail 73956 C57BL/6J ±  kb
transcript ENSMUST00000229028 Ensembl | MGI Sequence Detail 5732 Not Applicable  
polypeptide ENSMUSP00000154853 Ensembl | MGI Sequence Detail 337 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14411, MGI:2146025
References
more
  • Summaries
    All 63
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 7
    Phenotypes 31
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:252096 Paul A, et al., Transcriptional Architecture of Synaptic Communication Delineates GABAergic Neuron Identity. Cell. 2017 Oct 19;171(3):522-539.e20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory