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Shb
Gene Detail
 Symbol
Name
ID
Shb
src homology 2 domain-containing transforming protein B
MGI:98294
Feature Type protein coding gene
Genetic Map
Chromosome 4
24.00 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:45423278-45532470 bp, - strand
From VEGA annotation of GRCm38

  109193 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:74458  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Shb

Human
homologs
Human Homolog SHB, Src homology 2 domain containing adaptor protein B
NCBI Gene ID 6461
neXtProt AC  NX_Q15464
Human Synonyms  bA3J10.2
Human Chr (Location)  9p13.2; chr9:37915898-38069213 (-)  GRCh38
Alleles
and
phenotypes
All alleles(32) : Gene trapped(28) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit some embryonic lethality associated with various embryogenesis defects including loss of embryo structures, open neural tube, hemorrhaging and tail defects. Heterozygous mice exhibit a distortion in the transmission ratio of the allele maternally.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process angiogenesis, apoptotic process, ...
Component cytoplasm, membrane, ...
Function glycoprotein binding, SH3/SH2 adaptor activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (116)    Tissues (12)    Images (22)
Theiler Stages: 23
Assay TypeResults
RNA in situ 116
cDNA source data(60)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(60) cDNA(60)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006723 (Evidence)
Ensembl Gene ModelENSMUSG00000044813 (Evidence)
Entrez Gene230126 (Evidence)
UniGene251716
DFCITC1599187, TC1602950, TC1623365
DoTSDT.101171610, DT.91583905, DT.97359361
NIA Mouse Gene IndexU068309
Consensus CDS ProjectCCDS51173.1
International Mouse Knockout Project StatusShb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006723 VEGA Gene Model | MGI Sequence Detail 109193 C57BL/6J ±  kb
transcript OTTMUST00000015477 VEGA | MGI Sequence Detail 2244 Not Applicable 
polypeptide OTTMUSP00000007136 VEGA | MGI Sequence Detail 503 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(3) UniProt(3)
Polymorphisms SNPs within 2kb(976 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000980 SH2 domain
Protein Ontology PR:000014835 SH2 domain-containing adapter protein B
References (Earliest) J:16321 Welsh M, et al., Shb is a ubiquitously expressed Src homology 2 protein. Oncogene. 1994 Jan;9(1):19-27
(Latest) J:203580 Gustafsson K, et al., The Src homology 2 protein Shb promotes cell cycle progression in murine hematopoietic stem cells by regulation of focal adhesion kinase activity. Exp Cell Res. 2013 Jul 15;319(12):1852-64
All references(41)
Other
accession IDs
MGD-MRK-14400, MGI:2448529

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory