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Ccl1 Gene Detail
Summary
  • Symbol
    Ccl1
  • Name
    C-C motif chemokine ligand 1
  • Synonyms
    CCR8 ligand, I-309, Scya1, Tca-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98258
    NCBI Gene: 20290
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:82067492-82070638 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 49.99 cM
  • Mapping Data
    28 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98258
 protein coding gene Chr11:82067483-82196516 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018826
 protein coding gene Chr11:83420085-83558280 (-)
A/J MGP_AJ_G0018793
 protein coding gene Chr11:80215944-80348066 (-)
AKR/J MGP_AKRJ_G0018763
 protein coding gene Chr11:82619079-82749448 (-)
BALB/cJ MGP_BALBcJ_G0018766
 protein coding gene Chr11:80610254-80739860 (-)
C3H/HeJ MGP_C3HHeJ_G0018580
 protein coding gene Chr11:82662078-82798968 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019218
 protein coding gene Chr11:85932063-86066188 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016852
 protein coding gene Chr11:77179941-77317090 (-)
CAST/EiJ MGP_CASTEiJ_G0018135
 protein coding gene Chr11:83207905-83358883 (-)
CBA/J MGP_CBAJ_G0018551
 protein coding gene Chr11:89699799-89840186 (-)
DBA/2J MGP_DBA2J_G0018659
 protein coding gene Chr11:79780006-79910467 (-)
FVB/NJ MGP_FVBNJ_G0018648
 protein coding gene Chr11:79319462-79450411 (-)
LP/J MGP_LPJ_G0018729
 protein coding gene Chr11:83950428-84084663 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018675
 protein coding gene Chr11:89875940-90008535 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019258
 protein coding gene Chr11:82880170-83008721 (-)
PWK/PhJ MGP_PWKPhJ_G0017905
 protein coding gene Chr11:80609354-80742354 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017696
 protein coding gene Chr11:82495973-82628675 (-)
WSB/EiJ MGP_WSBEiJ_G0018187
 protein coding gene Chr11:82765484-82898571 (-)



Homology
more
  • Human Ortholog
    CCL1, C-C motif chemokine ligand 1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL1, C-C motif chemokine ligand 1
  • Synonyms
    I-309, P500, SCYA1, SISe, TCA3
  • Links
    NCBI Gene ID: 6346
    neXtProt AC: NX_P22362
    UniProt: P22362

  • Chr Location
    17q12; chr17:34360328-34363233 (-)  GRCh38
Human Diseases
more
  • Diseases
    4 with human CCL1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null allele are refractory to the anti-inflammatory response of the statin drug lovastatin and fail to exhibit an increase in regulatory T cell recruitment to sites of inflammation in a model of delayed-type hypersensitivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    21
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    26
  • cDNA Data
    11
  • Literature Summary
    3
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20290 NCBI Gene Model | MGI Sequence Detail 3147 C57BL/6J ±  kb
transcript NM_011329 RefSeq | MGI Sequence Detail 505 Not Specified  
polypeptide P10146 UniProt | EBI | MGI Sequence Detail 92 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 3
    cDNA 11
    Primer pair 3
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14332, MGD-MRK-14736, MGI:2671062
References
more
  • Summaries
    All 77
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:311437 Liu SS, et al., The chemokine CCL1 triggers an AMFR-SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis. Immunity. 2021 Sep 14;54(9):2042-2056.e8
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory