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Ccl1 Gene Detail
Summary
  • Symbol
    Ccl1
  • Name
    chemokine (C-C motif) ligand 1
  • Synonyms
    CCR8 ligand, I-309, Scya1, Tca-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98258
    NCBI Gene: 20290
Location & Maps
more
  • Sequence Map
    Chr11:82176657-82305690 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      129034 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 49.99 cM
  • Mapping Data
    28 experiments
Homology
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  • Human Ortholog
    CCL1, C-C motif chemokine ligand 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CCL1, C-C motif chemokine ligand 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    I-309, P500, SCYA1, SISe, TCA3
  • Links
    NCBI Gene ID: 6346
    neXtProt AC: NX_P22362

  • Chr Location
    17q12; chr17:34360328-34363233 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Ccl1
  • Incidental Mutations
Mice homozygous for a targeted null allele are refractory to the anti-inflammatory response of the statin drug lovastatin and fail to exhibit an increase in regulatory T cell recruitment to sites of inflammation in a model of delayed-type hypersensitivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000926 VEGA Gene Model | MGI Sequence Detail 129034 C57BL/6J ±  kb
transcript OTTMUST00000001804 VEGA | MGI Sequence Detail 514 Not Applicable  
polypeptide OTTMUSP00000000867 VEGA | MGI Sequence Detail 92 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    918 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000001985 C-C motif chemokine 1
  • InterPro Domains
    IPR000827 CC chemokine, conserved site
    IPR001811 Chemokine interleukin-8-like domain
Molecular
Reagents
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  • All nucleic 18
    Genomic 3
    cDNA 10
    Primer pair 3
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-14332, MGD-MRK-14736, MGI:2671062
References
more
  • Summaries
    All 54
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 11
  • Earliest
    J:8889 Burd PR, et al., Cloning and characterization of a novel T cell activation gene. J Immunol. 1987 Nov 1;139(9):3126-31
  • Latest
    J:217800 Ohama H, et al., M2b macrophage elimination and improved resistance of mice with chronic alcohol consumption to opportunistic infections. Am J Pathol. 2015 Feb;185(2):420-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory