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Ccl1 Gene Detail
Summary
  • Symbol
    Ccl1
  • Name
    chemokine (C-C motif) ligand 1
  • Synonyms
    CCR8 ligand, I-309, Scya1, Tca-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98258
    NCBI Gene: 20290
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:82176666-82179812 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 49.99 cM
  • Mapping Data
    28 experiments
Strain
Comparison
more
  • SNPs within 2kb
    45 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98258
protein coding gene Chr11:82176657-82305690 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018826
protein coding gene Chr11:83420085-83558280 (-)
A/J MGP_AJ_G0018793
protein coding gene Chr11:80215944-80348066 (-)
AKR/J MGP_AKRJ_G0018763
protein coding gene Chr11:82619079-82749448 (-)
BALB/cJ MGP_BALBcJ_G0018766
protein coding gene Chr11:80610254-80739860 (-)
C3H/HeJ MGP_C3HHeJ_G0018580
protein coding gene Chr11:82662078-82798968 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019218
protein coding gene Chr11:85932063-86066188 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016852
protein coding gene Chr11:77179941-77317090 (-)
CAST/EiJ MGP_CASTEiJ_G0018135
protein coding gene Chr11:83207905-83358883 (-)
CBA/J MGP_CBAJ_G0018551
protein coding gene Chr11:89699799-89840186 (-)
DBA/2J MGP_DBA2J_G0018659
protein coding gene Chr11:79780006-79910467 (-)
FVB/NJ MGP_FVBNJ_G0018648
protein coding gene Chr11:79319462-79450411 (-)
LP/J MGP_LPJ_G0018729
protein coding gene Chr11:83950428-84084663 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018675
protein coding gene Chr11:89875940-90008535 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019258
protein coding gene Chr11:82880170-83008721 (-)
PWK/PhJ MGP_PWKPhJ_G0017905
protein coding gene Chr11:80609354-80742354 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017696
protein coding gene Chr11:82495973-82628675 (-)
WSB/EiJ MGP_WSBEiJ_G0018187
protein coding gene Chr11:82765484-82898571 (-)



Homology
more
  • Human Ortholog
    CCL1, C-C motif chemokine ligand 1
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CCL1, C-C motif chemokine ligand 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    I-309, P500, SCYA1, SISe, TCA3
  • Links
    NCBI Gene ID: 6346
    neXtProt AC: NX_P22362
    UniProt: P22362

  • Chr Location
    17q12; chr17:34360328-34363233 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null allele are refractory to the anti-inflammatory response of the statin drug lovastatin and fail to exhibit an increase in regulatory T cell recruitment to sites of inflammation in a model of delayed-type hypersensitivity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20290 NCBI Gene Model | MGI Sequence Detail 3147 C57BL/6J ±  kb
transcript NM_011329 RefSeq | MGI Sequence Detail 505 Not Specified  
polypeptide P10146 UniProt | EBI | MGI Sequence Detail 92 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    Genomic 3
    cDNA 11
    Primer pair 3
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-14332, MGD-MRK-14736, MGI:2671062
References
more
  • Summaries
    All 71
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:240215 Farmaki E, et al., A CCL8 gradient drives breast cancer cell dissemination. Oncogene. 2016 Dec 08;35(49):6309-6318

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
08/06/2019
MGI 6.14
The Jackson Laboratory