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Msr1
Gene Detail
Symbol

Name
ID
Msr1
macrophage scavenger receptor 1
MGI:98257
Synonyms
MRS-A, MSR-A, Scara1, Scvr, SR-AI, SR-AII
Feature Type
protein coding gene
Genetic Map
Chromosome 8
23.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr8:39581700-39642678 bp, - strand
From NCBI annotation of GRCm38

  60979 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12822  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: macrophage scavenger receptor
Gene Tree: Msr1

Human
homologs
Human Homolog MSR1, macrophage scavenger receptor 1
NCBI Gene ID 4481
neXtProt AC  NX_P21757
Human Synonyms  CD204, phSR1, phSR2, SCARA1, SRA, SR-A
Human Chr (Location)  8p22; chr8:16107878-16192791 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human MSR1
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit abnormal uptake and degradation of acetylated low density lipoproteins by macrophages, increased interleukin-12 secretion in response to CpG oligodeoxynucleotide administration, and increased bacterial and viral infection induced morbidity/mortality.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Msr1 interacts with 320 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cholesterol transport, endocytosis, ...
Component collagen trimer, cytoplasmic vesicle, ...
Function low-density lipoprotein particle binding, scavenger receptor activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (57)    Tissues (54)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 11
RT-PCR 46
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(2) cDNA(25) Primer pair(2)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000025044 (Evidence)
Entrez Gene20288 (Evidence)
UniGene239291
DFCITC1577205, TC1590792
DoTSDT.99665171, DT.99857579, DT.99857580
NIA Mouse Gene IndexU029747
Consensus CDS ProjectCCDS52542.1, CCDS52543.1
International Mouse Knockout Project StatusMsr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20288 NCBI Gene Model | MGI Sequence Detail 60979 C57BL/6J ±  kb
transcript NM_031195 RefSeq | MGI Sequence Detail 3643 C57BL/6 
polypeptide P30204 UniProt | EBI | MGI Sequence Detail 458 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(8) UniProt(7)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(602 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR003543 Macrophage scavenger receptor
InterPro IPR001190 Speract/scavenger receptor
InterPro IPR017448 Speract/scavenger receptor-related
Protein Ontology PR:000001885 macrophage scavenger receptor types I and II
Graphical View of Protein Domain Structure
References
(Earliest) J:10839 Freeman M, et al., An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Proc Natl Acad Sci U S A. 1990 Nov;87(22):8810-4
(Latest) J:209897 Ramakrishnan R, et al., Oxidized lipids block antigen cross-presentation by dendritic cells in cancer. J Immunol. 2014 Mar 15;192(6):2920-31
All references(156)
Other
accession IDs
MGD-MRK-14331

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory