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Msr1 Gene Detail
Summary
  • Symbol
    Msr1
  • Name
    macrophage scavenger receptor 1
  • Synonyms
    MRS-A, MSR-A, Scara1, Scvr, SR-AI, SR-AII
  • Feature Type
    protein coding gene
  • IDs
    MGI:98257
    NCBI Gene: 20288
  • Gene Overview
    MyGene.info: MSR1
Location & Maps
more
  • Sequence Map
    Chr8:39581685-39642673 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      60989 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    MSR1, macrophage scavenger receptor 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MSR1, macrophage scavenger receptor 1
    Orthology source: HomoloGene
  • Synonyms
    CD204, phSR1, phSR2, SCARA1, SRA, SR-A
  • Links
    NCBI Gene ID: 4481
    neXtProt AC: NX_P21757

  • Chr Location
    8p22; chr8:16107878-16192791 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human MSR1 associations

Human Disease Mouse Models
       Barrett Esophagus   OMIM: 614266
Prostate Cancer   OMIM: 176807
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    112 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal uptake and degradation of acetylated low density lipoproteins by macrophages, increased interleukin-12 secretion in response to CpG oligodeoxynucleotide administration, and increased bacterial and viral infection induced morbidity/mortality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000061057 VEGA Gene Model | MGI Sequence Detail 60989 C57BL/6J ±  kb
transcript OTTMUST00000149172 VEGA | MGI Sequence Detail 1424 Not Applicable  
polypeptide OTTMUSP00000077437 VEGA | MGI Sequence Detail 458 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    958 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    Genomic 2
    cDNA 25
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-14331
References
more
  • Summaries
    All 162
    Developmental Gene Expression 5
    Diseases 1
    Gene Ontology 5
    Phenotypes 112
  • Earliest
    J:10839 Freeman M, et al., An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Proc Natl Acad Sci U S A. 1990 Nov;87(22):8810-4
  • Latest
    J:231550 Muczynski V, et al., Macrophage receptor SR-AI is crucial to maintain normal plasma levels of coagulation factor X. Blood. 2016 Feb 11;127(6):778-86

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory