Msr1
Gene Detail

Symbol Name ID

Msr1 macrophage scavenger receptor 1 MGI:98257

Synonyms

MRS-A, MSR-A, Scara1, Scvr, SR-AI, SR-AII

Feature Type

protein coding gene

Genetic Map

Chromosome 8

23.89 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr8:39581700-39642678 bp, - strand From NCBI annotation of GRCm38   60979 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic; rabbit, European    (Mammalian Orthology)
Comparative Map (Mouse/Human Msr1 ± 2 cM)

Protein SuperFamily: macrophage scavenger receptor
Gene Tree: Msr1

Human ortholog

MSR1 macrophage scavenger receptor 1 NCBI Gene ID 4481
Human Synonyms: CD204, phSR1, phSR2, SCARA1, SRA, SR-A
Human Chr8:15965387-16050300 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human MSR1 (2)

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-out allele exhibit abnormal uptake and degradation of acetylated low density lipoproteins by macrophages, increased interleukin-12 secretion in response to CpG oligodeoxynucleotide administration, and increased bacterial and viral infection induced morbidity/mortality.

 
Human Diseases Modeled Using Mouse Msr1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	cholesterol transport, endocytosis, ...
Component	collagen, cytoplasmic vesicle, ...
Function	low-density lipoprotein particle binding, scavenger receptor activity

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (57)    Tissues (54)    Images (8)
Theiler Stages: 13, 15, 17, 21, 23, 28

Assay Type	Results
Immunohistochemistry	11
RT-PCR	46

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(2) cDNA(25) Primer pair(2)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000025044 (Evidence)
Entrez Gene	20288 (Evidence)
UniGene	239291
DFCI	TC1577205, TC1590792
DoTS	DT.99665171, DT.99857579, DT.99857580
NIA Mouse Gene Index	U029747
Consensus CDS Project	CCDS52542.1, CCDS52543.1
International Mouse Knockout Project Status	Msr1

Sequences

Length	Strain/Species
genomic	20288	NCBI Gene Model | MGI Sequence Detail	60979	C57BL/6J
transcript	NM_031195	RefSeq | MGI Sequence Detail	3643	C57BL/6
polypeptide	P30204	UniProt | EBI | MGI Sequence Detail	458	Not Applicable

All sequences(35) RefSeq(4) UniProt(4)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(220 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008160	Collagen triple helix repeat
InterPro	IPR003543	Macrophage scavenger receptor
InterPro	IPR001190	Speract/scavenger receptor
InterPro	IPR017448	Speract/scavenger receptor-related
Protein Ontology	PR:000001885	macrophage scavenger receptor types I and II

Graphical View of Protein Domain Structure

References

(Earliest) J:10839 Freeman M, et al., An ancient, highly conserved family of cysteine-rich protein domains revealed by cloning type I and type II murine macrophage scavenger receptors. Proc Natl Acad Sci U S A. 1990 Nov;87(22):8810-4
(Latest) J:192417 Xu Y, et al., Class A scavenger receptor promotes cerebral ischemic injury by pivoting microglia/macrophage polarization. Neuroscience. 2012 Aug 30;218:35-48
All references(142)

Other accession IDs

MGD-MRK-14331