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Ptprs Gene Detail
Summary
  • Symbol
    Ptprs
  • Name
    protein tyrosine phosphatase, receptor type, S
  • Synonyms
    PTP-NU3, PTPsigma, Ptpt9, RPTPsigma
  • Feature Type
    protein coding gene
  • IDs
    MGI:97815
    NCBI Gene: 19280
  • Gene Overview
    MyGene.info: PTPRS
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:56412426-56476480 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.32 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    27 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97815
protein coding gene Chr17:56412426-56476483 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023926
protein coding gene Chr17:58106920-58174240 (-)
A/J MGP_AJ_G0023884
protein coding gene Chr17:56514123-56577963 (-)
AKR/J MGP_AKRJ_G0023853
protein coding gene Chr17:57210781-57276212 (-)
BALB/cJ MGP_BALBcJ_G0023885
protein coding gene Chr17:56336160-56400335 (-)
C3H/HeJ MGP_C3HHeJ_G0023649
protein coding gene Chr17:57936006-58001410 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024331
protein coding gene Chr17:60372433-60436088 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021777
protein coding gene Chr17:52999142-53062990 (-)
CAST/EiJ MGP_CASTEiJ_G0023131
protein coding gene Chr17:58228812-58291833 (-)
CBA/J MGP_CBAJ_G0023625
protein coding gene Chr17:62716034-62789369 (-)
DBA/2J MGP_DBA2J_G0023753
protein coding gene Chr17:55222454-55285989 (-)
FVB/NJ MGP_FVBNJ_G0023719
protein coding gene Chr17:54752583-54817432 (-)
LP/J MGP_LPJ_G0023835
protein coding gene Chr17:58791191-58858531 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023747
protein coding gene Chr17:62213317-62276779 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024375
protein coding gene Chr17:57579675-57644504 (-)
PWK/PhJ MGP_PWKPhJ_G0022877
protein coding gene Chr17:54576980-54640816 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022688
protein coding gene Chr17:54332381-54397869 (-)
WSB/EiJ MGP_WSBEiJ_G0023197
protein coding gene Chr17:58184199-58251021 (-)



Homology
more
  • Human Ortholog
    PTPRS, protein tyrosine phosphatase receptor type S
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PTPRS, protein tyrosine phosphatase receptor type S
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PTPSIGMA, R-PTP-S, R-PTP-sigma
  • Links
    NCBI Gene ID: 5802
    neXtProt AC: NX_Q13332
    UniProt: Q13332

  • Chr Location
    19p13.3; chr19:5205503-5340803 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    18 phenotypes from 3 alleles in 6 genetic backgrounds
    33 phenotypes from multigenic genotypes
    5 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Almost half of null homozygotes die in the first day of life. Embryos are characterized by decreased brain size including small pituitary glands and small olfactory bulbs. Adult mice are small, lack estrus, have decreased litter sizes and have impairedolfaction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19280 NCBI Gene Model | MGI Sequence Detail 64055 C57BL/6J ±  kb
    transcript NM_011218 RefSeq | MGI Sequence Detail 6874 C57BL/6  
    polypeptide B0V2N1 UniProt | EBI | MGI Sequence Detail 1907 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 420
      cDNA 419
      Primer pair 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13684, MGI:2146946
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 15
      Gene Ontology 13
      Phenotypes 33
    • Earliest
      J:4150 Schepens J, et al., Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain. Mol Biol Rep. 1992 Sep;16(4):241-8
    • Latest
      J:268686 Luo F, et al., Modulation of proteoglycan receptor PTPsigma enhances MMP-2 activity to promote recovery from multiple sclerosis. Nat Commun. 2018 Oct 8;9(1):4126

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    07/16/2019
    MGI 6.14
    The Jackson Laboratory