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Ptprs Gene Detail
Summary
  • Symbol
    Ptprs
  • Name
    protein tyrosine phosphatase, receptor type, S
  • Synonyms
    PTP-NU3, PTPsigma, Ptpt9, RPTPsigma
  • Feature Type
    protein coding gene
  • IDs
    MGI:97815
    NCBI Gene: 19280
  • Gene Overview
    MyGene.info: PTPRS
Location & Maps
more
  • Sequence Map
    Chr17:56412431-56476483 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      64053 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 29.32 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    PTPRS, protein tyrosine phosphatase, receptor type S
  • Vertebrate Orthologs
    7
  • Human Ortholog
    PTPRS, protein tyrosine phosphatase, receptor type S
    Orthology source: HomoloGene
  • Synonyms
    PTPSIGMA, R-PTP-S, R-PTP-sigma
  • Links
    NCBI Gene ID: 5802
    neXtProt AC: NX_Q13332

  • Chr Location
    19p13.3; chr19:5205503-5340803 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 5 genetic backgrounds
    33 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Almost half of null homozygotes die in the first day of life. Embryos are characterized by decreased brain size including small pituitary glands and small olfactory bulbs. Adult mice are small, lack estrus, have decreased litter sizes and have impairedolfaction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000014929 VEGA Gene Model | MGI Sequence Detail 64053 C57BL/6J ±  kb
transcript OTTMUST00000035454 VEGA | MGI Sequence Detail 6855 Not Applicable  
polypeptide OTTMUSP00000015868 VEGA | MGI Sequence Detail 1907 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    27 from dbSNP Build 142
  • RFLP
Protein
Information
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Molecular
Reagents
less
  • All nucleic 419
    cDNA 418
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-13684, MGI:2146946
References
more
  • Summaries
    All 67
    Developmental Gene Expression 13
    Gene Ontology 6
    Phenotypes 28
  • Earliest
    J:4150 Schepens J, et al., Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain. Mol Biol Rep. 1992 Sep;16(4):241-8
  • Latest
    J:229257 Gu Z, et al., Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion. PLoS One. 2015;10(3):e0121550

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory