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Ptprc
Gene Detail
Symbol

Name
ID
Ptprc
protein tyrosine phosphatase, receptor type, C
MGI:97810
Synonyms
B220, CD45, Ly-5, Lyt-4, T200
Feature Type
protein coding gene
Genetic Map
Chromosome 1
60.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr1:138062861-138175708 bp, - strand
From VEGA annotation of GRCm38

  112848 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PTPRC
Protein SuperFamily: leukocyte common antigen
Gene Tree: Ptprc

Human
homologs
PTPRC, protein tyrosine phosphatase, receptor type, C
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5788
neXtProt AC: NX_P08575

Human Synonyms: B220, CD45, CD45R, GP180, LCA, L-CA, LY5, T200

Human Chr (Location): 1q31-q32; chr1:198638968-198757476 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human PTPRC

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Chemically induced (ENU)(7) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants have defective T cell, B cell, and NK cell morphology and physiology. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death.
 
Human Diseases Modeled in Mice Using Ptprc (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ptprc interacts with 315 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (80 annotations)
Process activation of MAPK activity, B cell differentiation, ...
Component cell periphery, cell surface, ...
Function heparan sulfate proteoglycan binding, heparin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (119 records)
Data Summary: Results (79)    Tissues (31)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 46
RNA in situ 29
RT-PCR 4
cDNA source data(235)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ptprc ; ZFIN ptprc    NEW 
Molecular
reagents
All nucleic(256) Genomic(16) cDNA(235) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000043098 (Evidence)
Ensembl Gene Model ENSMUSG00000026395 (Evidence)
Entrez Gene 19264 (Evidence)
UniGene 391573
DFCI TC1573000, TC1592704, TC1605209, TC1614008, TC1666888
DoTS DT.101192522, DT.101254812, DT.101311356, DT.101319236, DT.101335838, DT.101367407, DT.94206213
NIA Mouse Gene Index U021829
EC 3.1.3.48
Consensus CDS Project CCDS15330.2, CCDS48383.2, CCDS59542.1
International Mouse Phenotyping Consortium Status Ptprc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043098 VEGA Gene Model | MGI Sequence Detail 112848 C57BL/6J ±  kb
transcript OTTMUST00000113094 VEGA | MGI Sequence Detail 5074 Not Applicable 
polypeptide OTTMUSP00000063320 VEGA | MGI Sequence Detail 1293 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(18) UniProt(11)
Polymorphisms
All PCR and RFLP(13) : PCR(1) RFLP(12) SNPs within 2kb(830 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR029021 Protein-tyrosine phosphatase-like
InterPro IPR024739 Protein tyrosine phosphatase, receptor type, N-terminal
InterPro IPR000242 PTP type protein phosphatase
InterPro IPR016335 Receptor-type tyrosine-protein phosphatase C
InterPro IPR000387 Tyrosine specific protein phosphatases domain
Protein Ontology PR:000001006 receptor-type tyrosine-protein phosphatase C
References
(Earliest) J:12077 Komuro K, et al., Ly-5: a new lymphocyte antigen system. Immunogenetics. 1975;1:452-456
(Latest) J:223004 Mikucki ME, et al., Non-redundant requirement for CXCR3 signalling during tumoricidal T-cell trafficking across tumour vascular checkpoints. Nat Commun. 2015;6:7458
All references(448)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11992, MGD-MRK-12076, MGD-MRK-13679, MGD-MRK-1864, MGI:3584395

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory