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Ptprc
Gene Detail
 Symbol
Name
ID
Ptprc
protein tyrosine phosphatase, receptor type, C
MGI:97810
Synonyms B220, CD45, Ly-5, Lyt-4, T200
Feature Type protein coding gene
Genetic Map
Chromosome 1
60.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr1:138063413-138175706 bp, - strand
From VEGA annotation of GRCm38

  112294 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: leukocyte common antigen
Gene Tree: Ptprc

Human
homologs
Human Homolog PTPRC, protein tyrosine phosphatase, receptor type, C
NCBI Gene ID 5788
neXtProt AC  NX_P08575
Human Synonyms  B220, CD45, CD45R, GP180, LCA, L-CA, LY5, T200
Human Chr (Location)  1q31-q32; chr1:198638968-198757476 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human PTPRC
Alleles
and
phenotypes
All alleles(15) : Targeted(7) Chemically induced(5) Other(3)
 
Homozygous null mutants have defective T cell, B cell, and NK cell morphology and physiology. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death.
 
Human Diseases Modeled Using Mouse Ptprc (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (77 annotations)
Process activation of MAPK activity, B cell differentiation, ...
Component cell periphery, cell surface, ...
Function heparan sulfate proteoglycan binding, heparin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (106 records)
Data Summary: Results (74)    Tissues (28)    Images (43)
Theiler Stages: 15, 16, 17, 18, 19, 20, 21, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 41
RNA in situ 29
RT-PCR 4
cDNA source data(235)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(256) Genomic(16) cDNA(235) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000043098 (Evidence)
Ensembl Gene ModelENSMUSG00000026395 (Evidence)
Entrez Gene19264 (Evidence)
UniGene391573
DFCITC1573000, TC1592704, TC1605209, TC1614008, TC1666888
DoTSDT.101192522, DT.101254812, DT.101311356, DT.101319236, DT.101335838, DT.101367407, DT.94206213
NIA Mouse Gene IndexU021829
EC3.1.3.48
Consensus CDS ProjectCCDS15330.2, CCDS48383.2, CCDS59542.1
International Mouse Knockout Project StatusPtprc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043098 VEGA Gene Model | MGI Sequence Detail 112294 C57BL/6J ±  kb
transcript OTTMUST00000113094 VEGA | MGI Sequence Detail 5014 Not Applicable 
polypeptide OTTMUSP00000063320 VEGA | MGI Sequence Detail 1293 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(18) UniProt(11)
Polymorphisms All PCR and RFLP(13) : PCR(1) RFLP(12) SNPs within 2kb(822 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR016335 Leukocyte common antigen
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
InterPro IPR024739 Protein tyrosine phosphatase, receptor type, N-terminal
Protein Ontology PR:000001006 receptor-type tyrosine-protein phosphatase C
References (Earliest) J:12077 Komuro K, et al., Ly-5: a new lymphocyte antigen system. Immunogenetics. 1975;1:452-456
(Latest) J:206757 Florian MC, et al., A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing. Nature. 2013 Nov 21;503(7476):392-6
All references(411)
Other
accession IDs
MGD-MRK-11992, MGD-MRK-12076, MGD-MRK-13679, MGD-MRK-1864, MGI:3584395

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory