Ptprc
Gene Detail

Symbol Name ID

Ptprc protein tyrosine phosphatase, receptor type, C MGI:97810

Synonyms

B220, CD45, Ly-5, Lyt-4, T200

Feature Type

protein coding gene

Genetic Map

Chromosome 1

60.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)

Sequence Map

Chr1:138062861-138175305 bp, - strand From NCBI annotation of GRCm38   112445 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: leukocyte common antigen
Gene Tree: Ptprc

Human homologs

Human Homolog		PTPRC, protein tyrosine phosphatase, receptor type, C
NCBI Gene ID		5788
neXtProt AC		NX_P08575
Human Synonyms		B220, CD45, CD45R, GP180, LCA, L-CA, LY5, T200
Human Chr (Location)		1q31-q32; chr1:198608098-198726605 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human PTPRC

Alleles and phenotypes

All alleles(15) : Targeted(7) Chemically induced(5) Other(3)
 

Homozygous null mutants have defective T cell, B cell, and NK cell morphology and physiology. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death.

 
Human Diseases Modeled Using Mouse Ptprc (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (76 annotations)

Process	activation of MAPK activity, B cell differentiation, ...
Component	cell periphery, cell surface, ...
Function	heparan sulfate proteoglycan binding, heparin binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (101 records)
Data Summary: Results (49)    Tissues (16)    Images (31)
Theiler Stages: 15, 16, 18, 19, 20, 21, 23, 25, 28

Assay Type	Results
Immunohistochemistry	18
RNA in situ	29
RT-PCR	2

cDNA source data(232)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(252) Genomic(16) cDNA(232) Primer pair(3) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000026395 (Evidence)
Entrez Gene	19264 (Evidence)
UniGene	391573
DFCI	TC1573000, TC1592704, TC1605209, TC1614008, TC1666888
DoTS	DT.101192522, DT.101254812, DT.101311356, DT.101319236, DT.101335838, DT.101367407, DT.94206213
NIA Mouse Gene Index	U021829
EC	3.1.3.48
Consensus CDS Project	CCDS15330.1, CCDS48383.1
International Mouse Knockout Project Status	Ptprc

Sequences

Length	Strain/Species
genomic	19264	NCBI Gene Model | MGI Sequence Detail	112445	C57BL/6J
transcript	NM_001111316	RefSeq | MGI Sequence Detail	5568	C57BL/6
polypeptide	P06800	UniProt | EBI | MGI Sequence Detail	1291	Not Applicable

All sequences(56) RefSeq(6) UniProt(6)

Polymorphisms

All PCR and RFLP(13) : PCR(1) RFLP(12) SNPs(690 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR016335	Leukocyte common antigen
InterPro	IPR000387	Protein-tyrosine/Dual-specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
InterPro	IPR024739	Protein tyrosine phosphatase, receptor type, N-terminal
Protein Ontology	PR:000001006	receptor-type tyrosine-protein phosphatase C

Graphical View of Protein Domain Structure

References

(Earliest) J:12077 Komuro K, et al., Ly-5: a new lymphocyte antigen system. Immunogenetics. 1975;1:452-456
(Latest) J:194614 Coleman MA, et al., Tolerance induction with gene-modified stem cells and immune-preserving conditioning in primed mice: restricting antigen to differentiated antigen-presenting cells permits efficacy. Blood. 2013 Feb 7;121(6):1049-58
All references(383)

Other accession IDs

MGD-MRK-11992, MGD-MRK-12076, MGD-MRK-13679, MGD-MRK-1864, MGI:3584395