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Ptprc Gene Detail
Summary
  • Symbol
    Ptprc
  • Name
    protein tyrosine phosphatase, receptor type, C
  • Synonyms
    B220, CD45, Ly-5, Lyt-4, T200
  • Feature Type
    protein coding gene
  • IDs
    MGI:97810
    NCBI Gene: 19264
  • Gene Overview
    MyGene.info: PTPRC
Location & Maps
more
  • Sequence Map
    Chr1:138062861-138175708 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      112848 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 60.73 cM
  • Mapping Data
    28 experiments
Homology
more
  • Human Ortholog
    PTPRC, protein tyrosine phosphatase, receptor type C
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PTPRC, protein tyrosine phosphatase, receptor type C
    Orthology source: HomoloGene
  • Synonyms
    B220, CD45, CD45R, GP180, LCA, L-CA, LY5, T200
  • Links
    NCBI Gene ID: 5788
    neXtProt AC: NX_P08575

  • Chr Location
    1q31-q32; chr1:198638968-198757476 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Ptprc mouse models; 2 with human PTPRC associations

Human Disease Mouse Models
       Systemic Lupus Erythematosus; SLE   OMIM: 152700 View 3 models
       Hepatitis C Virus, Susceptibility to   OMIM: 609532
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Positive   OMIM: 608971
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    106 phenotypes from 13 alleles in 19 genetic backgrounds
    39 phenotypes from multigenic genotypes
    189 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (ENU)
    8
  • Chemically induced (other)
    2
  • Radiation induced
    1
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    3 involving Ptprc
  • Incidental Mutations
Homozygous null mutants have defective T cell, B cell, and NK cell morphology and physiology. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043098 VEGA Gene Model | MGI Sequence Detail 112848 C57BL/6J ±  kb
transcript OTTMUST00000113094 VEGA | MGI Sequence Detail 5074 Not Applicable  
polypeptide OTTMUSP00000063320 VEGA | MGI Sequence Detail 1293 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    830 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • EC
  • InterPro Domains
    IPR003961 Fibronectin type III
    IPR013783 Immunoglobulin-like fold
    IPR016130 Protein-tyrosine phosphatase, active site
    IPR003595 Protein-tyrosine phosphatase, catalytic
    IPR029021 Protein-tyrosine phosphatase-like
    IPR024739 Protein tyrosine phosphatase, receptor type, N-terminal
    IPR000242 PTP type protein phosphatase
    IPR016335 Receptor-type tyrosine-protein phosphatase C
    IPR000387 Tyrosine specific protein phosphatases domain
Molecular
Reagents
less
  • All nucleic 256
    Genomic 16
    cDNA 235
    Primer pair 4
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-11992, MGD-MRK-12076, MGD-MRK-13679, MGD-MRK-1864, MGI:3584395
References
more
  • Summaries
    All 465
    Developmental Gene Expression 124
    Diseases 3
    Gene Ontology 70
    Phenotypes 189
  • Earliest
    J:12077 Komuro K, et al., Ly-5: a new lymphocyte antigen system. Immunogenetics. 1975;1:452-456
  • Latest
    J:232644 Mirantes C, et al., Deletion of Pten in CD45-expressing cells leads to development of T-cell lymphoblastic lymphoma but not myeloid malignancies. Blood. 2016 Apr 14;127(15):1907-11

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory