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Ptprc
Gene Detail
Symbol

Name
ID
Ptprc
protein tyrosine phosphatase, receptor type, C
MGI:97810
Synonyms
B220, CD45, Ly-5, Lyt-4, T200
Feature Type
protein coding gene
Genetic Map
Chromosome 1
60.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr1:138063407-138175706 bp, - strand
From VEGA annotation of GRCm38

  112300 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: leukocyte common antigen
Gene Tree: Ptprc

Human
homologs
Human Homolog PTPRC, protein tyrosine phosphatase, receptor type, C
NCBI Gene ID 5788
neXtProt AC  NX_P08575
Human Synonyms  B220, CD45, CD45R, GP180, LCA, L-CA, LY5, T200
Human Chr (Location)  1q31-q32; chr1:198638968-198757476 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human PTPRC
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(5) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants have defective T cell, B cell, and NK cell morphology and physiology. Mice carrying an engineered point mutation exhibit lymphoproliferation and autoimmunity that leads to premature death.
 
Human Diseases Modeled Using Mouse Ptprc (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ptprc interacts with 315 markers (Mir1b, Mir7-1, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (78 annotations)
Process activation of MAPK activity, B cell differentiation, ...
Component cell periphery, cell surface, ...
Function heparan sulfate proteoglycan binding, heparin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (114 records)
Data Summary: Results (75)    Tissues (29)    Images (43)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 42
RNA in situ 29
RT-PCR 4
cDNA source data(235)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(256) Genomic(16) cDNA(235) Primer pair(4) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000043098 (Evidence)
Ensembl Gene ModelENSMUSG00000026395 (Evidence)
Entrez Gene19264 (Evidence)
UniGene391573
DFCITC1573000, TC1592704, TC1605209, TC1614008, TC1666888
DoTSDT.101192522, DT.101254812, DT.101311356, DT.101319236, DT.101335838, DT.101367407, DT.94206213
NIA Mouse Gene IndexU021829
EC3.1.3.48
Consensus CDS ProjectCCDS15330.2, CCDS48383.2, CCDS59542.1
International Mouse Knockout Project StatusPtprc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043098 VEGA Gene Model | MGI Sequence Detail 112300 C57BL/6J ±  kb
transcript OTTMUST00000113094 VEGA | MGI Sequence Detail 5074 Not Applicable 
polypeptide OTTMUSP00000063320 VEGA | MGI Sequence Detail 1293 Not Applicable 

For the selected sequences
All sequences(109) RefSeq(18) UniProt(17)
Polymorphisms
All PCR and RFLP(13) : PCR(1) RFLP(12) SNPs within 2kb(822 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR016335 Leukocyte common antigen
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
InterPro IPR024739 Protein tyrosine phosphatase, receptor type, N-terminal
Protein Ontology PR:000001006 receptor-type tyrosine-protein phosphatase C
References
(Earliest) J:12077 Komuro K, et al., Ly-5: a new lymphocyte antigen system. Immunogenetics. 1975;1:452-456
(Latest) J:214813 Liakhovitskaia A, et al., Runx1 is required for progression of CD41+ embryonic precursors into HSCs but not prior to this. Development. 2014 Sep;141(17):3319-23
All references(433)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11992, MGD-MRK-12076, MGD-MRK-13679, MGD-MRK-1864, MGI:3584395

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory