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Pth
Gene Detail
Symbol

Name
ID
Pth
parathyroid hormone
MGI:97799
Feature Type
protein coding gene
Genetic Map
Chromosome 7
59.19 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr7:113385576-113388573 bp, - strand
From NCBI annotation of GRCm38

  2998 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:266  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: parathyroid hormone
Gene Tree: Pth

Human
homologs
Human Homolog PTH, parathyroid hormone
NCBI Gene ID 5741
neXtProt AC  NX_P01270
Human Synonyms  PTH1
Human Chr (Location)  11p15.3-p15.1; chr11:13492054-13496020 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PTH
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
 
Homozygotes for a targeted null mutation exhibit diminished cartilage mineralization, and reductions in angiopoietin-1, neovascularization, metaphyseal osteoblasts, and trabecular bone.
 
Phenotype Images(2)
Interactions
Pth interacts with 57 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (42)    Tissues (31)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 33
RT-PCR 4
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(3) cDNA(20) Primer pair(3) Other(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000059077 (Evidence)
Entrez Gene19226 (Evidence)
UniGene284168
DFCITC1583391
DoTSDT.91338735
NIA Mouse Gene IndexU029141
Consensus CDS ProjectCCDS21756.1
International Mouse Knockout Project StatusPth
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19226 NCBI Gene Model | MGI Sequence Detail 2998 C57BL/6J ±  kb
transcript NM_020623 RefSeq | MGI Sequence Detail 717 C57BL/6 
polypeptide NP_065648 RefSeq | MGI Sequence Detail 115 C57BL/6 

For the selected sequences
All sequences(14) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003625 Parathyroid hormone
InterPro IPR001415 Parathyroid hormone/parathyroid hormone-related protein
Protein Ontology PR:000013429 parathyroid hormone
References
(Earliest) J:7342 Heinrich G, et al., Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and deduced amino acid sequence of rat preproparathyroid hormone. J Biol Chem. 1984 Mar 10;259(5):3320-9
(Latest) J:195936 Quinn SJ, et al., Interactions between calcium and phosphorus in the regulation of the production of fibroblast growth factor 23 in vivo. Am J Physiol Endocrinol Metab. 2013 Feb 1;304(3):E310-20
All references(100)
Other
accession IDs
MGD-MRK-13667

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory