Pth
Gene Detail

Symbol Name ID

Pth parathyroid hormone MGI:97799

Feature Type

protein coding gene

Genetic Map

Chromosome 7

59.19 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(18)

Sequence Map

Chr7:113385576-113388573 bp, - strand From NCBI annotation of GRCm38   2998 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:266  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: parathyroid hormone
Gene Tree: Pth

Human homologs

Human Homolog		PTH, parathyroid hormone
NCBI Gene ID		5741
neXtProt AC		NX_P01270
Human Synonyms		PTH1
Human Chr (Location)		11p15.3-p15.1; chr11:13513601-13517567 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PTH

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Homozygotes for a targeted null mutation exhibit diminished cartilage mineralization, and reductions in angiopoietin-1, neovascularization, metaphyseal osteoblasts, and trabecular bone.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (27 annotations)

Process	adenylate cyclase-activating G-protein coupled receptor signaling pathway, cell-cell signaling, ...
Component	extracellular space
Function	hormone activity, parathyroid hormone receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (20)    Tissues (9)    Images (15)
Theiler Stages: 15, 17, 19, 20, 21, 24, 26

Assay Type	Results
Immunohistochemistry	5
RNA in situ	11
RT-PCR	4

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(3) cDNA(20) Primer pair(3) Other(3)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000059077 (Evidence)
Entrez Gene	19226 (Evidence)
UniGene	284168
DFCI	TC1583391
DoTS	DT.91338735
NIA Mouse Gene Index	U029141
Consensus CDS Project	CCDS21756.1
International Mouse Knockout Project Status	Pth

Sequences

Length	Strain/Species
genomic	19226	NCBI Gene Model | MGI Sequence Detail	2998	C57BL/6J
transcript	NM_020623	RefSeq | MGI Sequence Detail	717	C57BL/6
polypeptide	NP_065648	RefSeq | MGI Sequence Detail	115	C57BL/6

All sequences(13) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs(27 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003625	Parathyroid hormone
InterPro	IPR001415	Parathyroid hormone/parathyroid hormone-related protein
Protein Ontology	PR:000013429	parathyroid hormone

References

(Earliest) J:7342 Heinrich G, et al., Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and deduced amino acid sequence of rat preproparathyroid hormone. J Biol Chem. 1984 Mar 10;259(5):3320-9
(Latest) J:190032 Bonnet N, et al., Regulation of beta catenin signaling and parathyroid hormone anabolic effects in bone by the matricellular protein periostin. Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):15048-53
All references(96)

Other accession IDs

MGD-MRK-13667