About   Help   FAQ
Pth
Gene Detail
Symbol

Name
ID
Pth
parathyroid hormone
MGI:97799
Feature Type
protein coding gene
Genetic Map
Chromosome 7
59.19 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr7:113385576-113388573 bp, - strand
From NCBI annotation of GRCm38

  2998 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:266  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: PTH
Protein SuperFamily: parathyroid hormone
Gene Tree: Pth

Human
homologs
PTH, parathyroid hormone
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5741
neXtProt AC: NX_P01270

Human Synonyms: PTH1

Human Chr (Location): 11p15.3-p15.1; chr11:13492054-13496020 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PTH

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from CvDC )
 
Homozygotes for a targeted null mutation exhibit diminished cartilage mineralization, and reductions in angiopoietin-1, neovascularization, metaphyseal osteoblasts, and trabecular bone.
 
Phenotype Images(2)
Interactions
Pth interacts with 57 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (14 records)
Data Summary: Results (42)    Tissues (31)    Images (16)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 33
RT-PCR 4
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PTH ZFIN pth1a, pth1b    NEW 
Molecular
reagents
All nucleic(29) Genomic(3) cDNA(20) Primer pair(3) Other(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000059077 (Evidence)
Entrez Gene 19226 (Evidence)
UniGene 284168
DFCI TC1583391
DoTS DT.91338735
NIA Mouse Gene Index U029141
Consensus CDS Project CCDS21756.1
International Mouse Phenotyping Consortium Status Pth
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19226 NCBI Gene Model | MGI Sequence Detail 2998 C57BL/6J ±  kb
transcript NM_020623 RefSeq | MGI Sequence Detail 717 C57BL/6 
polypeptide NP_065648 RefSeq | MGI Sequence Detail 115 C57BL/6 

For the selected sequences
All sequences(13) RefSeq(2) UniProt(1)
Polymorphisms
All PCR and RFLP(4) : PCR(1) RFLP(3) SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003625 Parathyroid hormone
InterPro IPR001415 Parathyroid hormone/parathyroid hormone-related protein
Protein Ontology PR:000013429 parathyroid hormone
References
(Earliest) J:7342 Heinrich G, et al., Gene encoding parathyroid hormone. Nucleotide sequence of the rat gene and deduced amino acid sequence of rat preproparathyroid hormone. J Biol Chem. 1984 Mar 10;259(5):3320-9
(Latest) J:217502 Chojnowski JL, et al., Multiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse. Development. 2014 Oct;141(19):3697-708
All references(95)
Other
accession IDs
MGD-MRK-13667

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory