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Prkar2b
Gene Detail
Symbol

Name
ID
Prkar2b
protein kinase, cAMP dependent regulatory, type II beta
MGI:97760
Synonyms
Pkarb2, PKARIIbeta, RII(beta)
Feature Type
protein coding gene
Genetic Map
Chromosome 12
13.74 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:31958476-32061296 bp, - strand
From VEGA annotation of GRCm38

  102821 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37666  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRKAR2B
Protein SuperFamily: cAMP-dependent protein kinase, regulatory subunit
Gene Tree: Prkar2b

Human
homologs
PRKAR2B, protein kinase, cAMP-dependent, regulatory, type II, beta
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5577
neXtProt AC: NX_P31323

Human Synonyms: PRKAR2, RII-BETA

Human Chr (Location): 7q22; chr7:107044728-107161811 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygou null mice are lean, weigh less than controls, and have reduced white fat pad size. Mice are resistant to both diet-induced obesity and to diet-induced insulin resistance. Mice show impaired coordination and increased sensitivity to chronic amphetamine exposure.
 
Interactions
Prkar2b interacts with 243 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process fatty acid metabolic process, learning, ...
Component cAMP-dependent protein kinase complex, centrosome, ...
Function cAMP binding, cAMP-dependent protein kinase inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (216)    Tissues (53)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 205
Northern blot 3
cDNA source data(87)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prkar2b    NEW 
Molecular
reagents
All nucleic(90) Genomic(2) cDNA(88)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000016980 (Evidence)
Ensembl Gene Model ENSMUSG00000002997 (Evidence)
Entrez Gene 19088 (Evidence)
UniGene 25594
DFCI TC1582287, TC1586026, TC1664826
DoTS DT.101336604, DT.101741259, DT.94263696
NIA Mouse Gene Index U033887
EC 2.7.1.37
PDB 3TNP, 3TNQ
Consensus CDS Project CCDS25869.1
International Mouse Phenotyping Consortium Status Prkar2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016980 VEGA Gene Model | MGI Sequence Detail 102821 C57BL/6J ±  kb
transcript OTTMUST00000041179 VEGA | MGI Sequence Detail 1657 Not Applicable 
polypeptide OTTMUSP00000018451 VEGA | MGI Sequence Detail 416 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(824 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002373 cAMP/cGMP-dependent protein kinase
InterPro IPR012198 cAMP-dependent protein kinase regulatory subunit
InterPro IPR003117 cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000013231 cAMP-dependent protein kinase type II-beta regulatory subunit
References
(Earliest) J:11311 Singh IS, et al., Molecular cloning and characterization of the promoter region of the mouse regulatory subunit RII beta of type II cAMP-dependent protein kinase. Biochem Biophys Res Commun. 1991 Jul 15;178(1):221-6
(Latest) J:206832 Parisiadou L, et al., LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Nat Neurosci. 2014 Mar;17(3):367-76
All references(68)
Other
accession IDs
MGD-MRK-13326, MGD-MRK-13611, MGI:2144832, MGI:2145000

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory