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Prkar2b Gene Detail
Summary
  • Symbol
    Prkar2b
  • Name
    protein kinase, cAMP dependent regulatory, type II beta
  • Synonyms
    Pkarb2, PKARIIbeta, RII(beta)
  • Feature Type
    protein coding gene
  • IDs
    MGI:97760
    NCBI Gene: 19088
  • Gene Overview
    MyGene.info: PRKAR2B
Location & Maps
more
  • Sequence Map
    Chr12:31958476-32061296 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      102821 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 13.74 cM, cytoband B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PRKAR2B, protein kinase cAMP-dependent type II regulatory subunit beta
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKAR2B, protein kinase cAMP-dependent type II regulatory subunit beta
    Orthology source: HomoloGene
  • Synonyms
    PRKAR2, RII-BETA
  • Links
    NCBI Gene ID: 5577
    neXtProt AC: NX_P31323

  • Chr Location
    7q22; chr7:107044728-107161811 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 3 alleles in 10 genetic backgrounds
    11 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Gene trapped
    1
  • Targeted
    6
  • Incidental Mutations
Homozygou null mice are lean, weigh less than controls, and have reduced white fat pad size. Mice are resistant to both diet-induced obesity and to diet-induced insulin resistance. Mice show impaired coordination and increased sensitivity to chronic amphetamine exposure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016980 VEGA Gene Model | MGI Sequence Detail 102821 C57BL/6J ±  kb
transcript OTTMUST00000041179 VEGA | MGI Sequence Detail 1657 Not Applicable  
polypeptide OTTMUSP00000018451 VEGA | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    826 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013231 cAMP-dependent protein kinase type II-beta regulatory subunit
  • PDB
  • EC
  • InterPro Domains
    IPR012198 cAMP-dependent protein kinase regulatory subunit
    IPR003117 cAMP-dependent protein kinase regulatory subunit, dimerization-anchoring domain
    IPR018488 Cyclic nucleotide-binding, conserved site
    IPR000595 Cyclic nucleotide-binding domain
    IPR018490 Cyclic nucleotide-binding-like
    IPR014710 RmlC-like jelly roll fold
Molecular
Reagents
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  • All nucleic 90
    Genomic 2
    cDNA 88

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-13326, MGD-MRK-13611, MGI:2144832, MGI:2145000
References
more
  • Summaries
    All 68
    Developmental Gene Expression 10
    Gene Ontology 9
    Phenotypes 25
  • Earliest
    J:11311 Singh IS, et al., Molecular cloning and characterization of the promoter region of the mouse regulatory subunit RII beta of type II cAMP-dependent protein kinase. Biochem Biophys Res Commun. 1991 Jul 15;178(1):221-6
  • Latest
    J:228307 Zhou T, et al., Palmitoyl acyltransferase Aph2 in cardiac function and the development of cardiomyopathy. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15666-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory