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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Prkar2b
protein kinase, cAMP dependent regulatory, type II beta
MGI:97760
33 phenotypes from 3 alleles in 10 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Prkar2btm1Gsm/Prkar2btm1Gsm
B6.129-Prkar2btm1Gsm 		abnormal food intake J:72414
decreased body weight J:72414
decreased circulating cholesterol level J:72414
decreased circulating insulin level J:72414
decreased circulating LDL cholesterol level J:72414
decreased circulating leptin level J:72414
decreased circulating VLDL cholesterol level J:72414
decreased liver triglyceride level J:72414
decreased susceptibility to diet-induced hepatic steatosis J:72414
decreased susceptibility to diet-induced obesity J:72414
normal homeostasis/metabolism phenotype J:72414
improved glucose tolerance J:72414
Prkar2btm1Gsm/Prkar2btm1Gsm
involves: 129X1/SvJ * C57BL/6 		enhanced behavioral response to addictive substance J:47453
impaired coordination J:47453
Prkar2btm1Gsm/Prkar2btm1Gsm
Not Specified 		abnormal energy expenditure J:34751
decreased body weight J:34751
decreased circulating leptin level J:34751
decreased susceptibility to diet-induced hepatic steatosis J:34751
decreased susceptibility to diet-induced obesity J:34751
decreased triglyceride level J:34751
decreased white adipose tissue amount J:34751
normal homeostasis/metabolism phenotype J:34751
increased body temperature J:34751
polyphagia J:34751
Prkar2btm2Gsm/Prkar2b+
involves: C57BL/6 		decreased circulating leptin level J:131039
decreased percent body fat/body weight J:131039
polyphagia J:131039
Prkar2btm2Gsm/Prkar2btm2Gsm
involves: C57BL/6 		decreased percent body fat/body weight J:131039
increased locomotor activity J:131039
Prkar2btm3Gsm/Prkar2btm2Gsm
Drd1tm1(cre)Rpa/Drd1+
involves: C57BL/6 		normal adipose tissue phenotype J:196157
normal growth/size/body region phenotype J:196157
normal homeostasis/metabolism phenotype J:196157
hyperactivity J:196157
Prkar2btm3Gsm/Prkar2btm2Gsm
Slc32a1tm2(cre)Lowl/Slc32a1+
involves: 129S6/SvEvTac * C57BL/6 		normal adipose tissue phenotype J:196157
normal behavior/neurological phenotype J:196157
normal growth/size/body region phenotype J:196157
normal homeostasis/metabolism phenotype J:196157
Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Drd2-cre)ER44Gsat/0
involves: C57BL/6 * FVB/N 		normal behavior/neurological phenotype J:196157
decreased body weight J:196157
decreased circulating leptin level J:196157
decreased total body fat amount J:196157
Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Fabp4-cre)1Rev/0
involves: C57BL/6 		decreased body weight J:196157
decreased circulating leptin level J:196157
decreased gonadal fat pad weight J:196157
decreased total body fat amount J:196157
increased locomotor activity J:196157
Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Ins2-cre)25Mgn/0
involves: C57BL/6 * DBA 		normal adipose tissue phenotype J:196157
normal behavior/neurological phenotype J:196157
normal growth/size/body region phenotype J:196157
normal homeostasis/metabolism phenotype J:196157
Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		normal adipose tissue phenotype J:196157
normal behavior/neurological phenotype J:196157
normal growth/size/body region phenotype J:196157
Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Ppp1r1b-cre)1Meeh/0
involves: C57BL/6 		normal behavior/neurological phenotype J:196157
decreased circulating leptin level J:196157
decreased lean body mass J:196157
Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Syn1-cre)671Jxm/0
involves: C57BL/6 * CBA 		normal adipose tissue phenotype J:196157
normal behavior/neurological phenotype J:196157
normal growth/size/body region phenotype J:196157
Prkar2btm3Gsm/Prkar2btm3Gsm
B6.Cg-Prkar2btm3Gsm 		abnormal energy expenditure J:196157
abnormal food intake J:196157
decreased body weight J:196157
decreased circulating cholesterol level J:196157
decreased circulating insulin level J:196157
decreased circulating LDL cholesterol level J:196157
decreased circulating leptin level J:196157
decreased circulating VLDL cholesterol level J:196157
decreased liver triglyceride level J:196157
decreased percent body fat/body weight J:196157
decreased susceptibility to diet-induced obesity J:196157
decreased susceptibility to hepatic steatosis J:196157
decreased triglyceride level J:196157
decreased white adipose tissue amount J:196157
hyperactivity J:196157
improved glucose tolerance J:196157
increased energy expenditure J:196157
increased respiratory quotient J:196157
Prkar2btm3Gsm/Prkar2btm3Gsm
B6.Cg-Prkar2btm3Gsm 		increased body weight J:196157
increased total body fat amount J:196157
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory