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Pomc
Gene Detail
Symbol

Name
ID
Pomc
pro-opiomelanocortin-alpha
MGI:97742
Synonyms
ACTH, adrenal corticotropic hormone, alpha-melanocyte stimulating hormone, alphaMSH, alpha-MSH, BE, beta-endorphin, beta-melanocyte stimulating hormone, beta-MSH, gamma-melanocyte stimulating hormone, gamma-MSH, POMC, Pomc-1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
1.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr12:3954951-3960618 bp, + strand
From Ensembl annotation of GRCm38

  5668 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:723  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: POMC
Protein SuperFamily: corticotropin-lipotropin
Gene Tree: Pomc

Human
homologs
POMC, proopiomelanocortin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5443
neXtProt AC: NX_P01189

Human Synonyms: ACTH, CLIP, LPH, MSH, NPP, POC

Human Chr (Location): 2p23.3; chr2:25160853-25168871 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human POMC

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
 
Homozygotes for a targeted null mutation are obese and exhibit abnormal hormone levels, abnormal pigmentation, increased food intake, and adiposity. Mice homozygous for another knock-out allele exhibit altered reward based behavior and immune response to LPS treatment.
 
Human Diseases Modeled in Mice Using Pomc (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)
Interactions
Pomc interacts with 28 markers (Mir128-2, Mir146, Mir193b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell-cell signaling, cellular pigmentation, ...
Component cytoplasm, extracellular region, ...
Function G-protein coupled receptor binding, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (126 records)
Data Summary: Results (271)    Tissues (178)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 28
RNA in situ 214
RT-PCR 29
cDNA source data(76)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA POMC ; Xenbase pomc ; ZFIN pomca, pomcb    NEW 
Molecular
reagents
All nucleic(94) Genomic(7) cDNA(82) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000020660 (Evidence)
Entrez Gene 18976 (Evidence)
UniGene 277996
DFCI TC1574394, TC1584844
DoTS DT.87028350, DT.87073255, DT.97359596, DT.99861914
NIA Mouse Gene Index U013711
Consensus CDS Project CCDS25785.1
International Mouse Phenotyping Consortium Status Pomc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020660 Ensembl Gene Model | MGI Sequence Detail 5668 C57BL/6J ±  kb
transcript ENSMUST00000020990 Ensembl | MGI Sequence Detail 1007 Not Applicable 
polypeptide ENSMUSP00000020990 Ensembl | MGI Sequence Detail 235 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(10) UniProt(1)
Polymorphisms
RFLP(7) : SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013532 Opiodes neuropeptide
InterPro IPR001941 Pro-opiomelanocortin/corticotropin, ACTH
InterPro IPR013531 Pro-opiomelanocortin/corticotropin, ACTH, central region
InterPro IPR013593 Pro-opiomelanocortin N-terminal
Protein Ontology PR:000013015 pro-opiomelanocortin
References
(Earliest) J:21792 Civelli O, et al., Detection and quantitation of pro-opiomelanocortin mRNA in pituitary and brain tissues from different species. J Biol Chem. 1982 Jun 25;257(12):6783-7
(Latest) J:221577 Sanz E, et al., Fertility-regulating Kiss1 neurons arise from hypothalamic POMC-expressing progenitors. J Neurosci. 2015 Apr 8;35(14):5549-56
All references(268)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-13580, MGD-MRK-13582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory