Pomc
Gene Detail

Symbol Name ID

Pomc pro-opiomelanocortin-alpha MGI:97742

Synonyms

ACTH, adrenal corticotropic hormone, alpha-melanocyte stimulating hormone, alphaMSH, alpha-MSH, BE, beta-endorphin, beta-melanocyte stimulating hormone, beta-MSH, gamma-melanocyte stimulating hormone, gamma-MSH, POMC, Pomc-1

Feature Type

protein coding gene

Genetic Map

Chromosome 12

1.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr12:3954951-3960618 bp, + strand From NCBI annotation of GRCm38   5668 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:723  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: corticotropin-lipotropin
Gene Tree: Pomc

Human homologs

Human Homolog		POMC, proopiomelanocortin
NCBI Gene ID		5443
neXtProt AC		NX_P01189
Human Synonyms		ACTH, CLIP, LPH, MSH, NPP, POC
Human Chr (Location)		2p23.3; chr2:25383722-25391559 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human POMC

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygotes for a targeted null mutation are obese and exhibit abnormal hormone levels, abnormal pigmentation, increased food intake, and adiposity. Mice homozygous for another knock-out allele exhibit altered reward based behavior and immune response to LPS treatment.

 
Human Diseases Modeled Using Mouse Pomc (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	cell-cell signaling, cellular pigmentation, ...
Component	cytoplasm, extracellular region, ...
Function	G-protein coupled receptor binding, hormone activity, ...

External Resources: FuncBase

Expression

Literature Summary: (108 records)
Data Summary: Results (246)    Tissues (169)    Images (45)
Theiler Stages: 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	17
RNA in situ	200
RT-PCR	29

cDNA source data(79)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(97) Genomic(7) cDNA(85) Primer pair(4) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000020660 (Evidence)
Entrez Gene	18976 (Evidence)
UniGene	277996
DFCI	TC1574394, TC1584844
DoTS	DT.87028350, DT.87073255, DT.97359596
NIA Mouse Gene Index	U013711
Consensus CDS Project	CCDS25785.1
International Mouse Knockout Project Status	Pomc

Sequences

Length	Strain/Species
genomic	18976	NCBI Gene Model | MGI Sequence Detail	5668	C57BL/6J
transcript	NM_008895	RefSeq | MGI Sequence Detail	1007	C57BL/6
polypeptide	P01193	UniProt | EBI | MGI Sequence Detail	235	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(7) : SNPs(40 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013532	Opiodes neuropeptide
InterPro	IPR001941	Pro-opiomelanocortin/corticotropin, ACTH
InterPro	IPR013531	Pro-opiomelanocortin/corticotropin, ACTH, central region
InterPro	IPR013593	Pro-opiomelanocortin N-terminal
Protein Ontology	PR:000013015	pro-opiomelanocortin

Graphical View of Protein Domain Structure

References

(Earliest) J:21792 Civelli O, et al., Detection and quantitation of pro-opiomelanocortin mRNA in pituitary and brain tissues from different species. J Biol Chem. 1982 Jun 25;257(12):6783-7
(Latest) J:193919 Lu F, et al., Rax is a selector gene for mediobasal hypothalamic cell types. J Neurosci. 2013 Jan 2;33(1):259-72
All references(246)

Other accession IDs

MGD-MRK-13580, MGD-MRK-13582