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Pomc
Gene Detail
Symbol

Name
ID
Pomc
pro-opiomelanocortin-alpha
MGI:97742
Synonyms
ACTH, adrenal corticotropic hormone, alpha-melanocyte stimulating hormone, alphaMSH, alpha-MSH, BE, beta-endorphin, beta-melanocyte stimulating hormone, beta-MSH, gamma-melanocyte stimulating hormone, gamma-MSH, POMC, Pomc-1
Feature Type
protein coding gene
Genetic Map
Chromosome 12
1.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)
Sequence Map
Chr12:3954951-3960618 bp, + strand
From Ensembl annotation of GRCm38

  5668 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:723  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: corticotropin-lipotropin
Gene Tree: Pomc

Human
homologs
Human Homolog POMC, proopiomelanocortin
NCBI Gene ID 5443
neXtProt AC  NX_P01189
Human Synonyms  ACTH, CLIP, LPH, MSH, NPP, POC
Human Chr (Location)  2p23.3; chr2:25160853-25168690 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human POMC
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
 
Homozygotes for a targeted null mutation are obese and exhibit abnormal hormone levels, abnormal pigmentation, increased food intake, and adiposity. Mice homozygous for another knock-out allele exhibit altered reward based behavior and immune response to LPS treatment.
 
Human Diseases Modeled Using Mouse Pomc (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(1)
Interactions
Pomc interacts with 28 markers (Mir128-2, Mir146, Mir193b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell-cell signaling, cellular pigmentation, ...
Component cytoplasm, extracellular region, ...
Function G-protein coupled receptor binding, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (116 records)
Data Summary: Results (246)    Tissues (171)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 200
RT-PCR 29
cDNA source data(76)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(94) Genomic(7) cDNA(82) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000020660 (Evidence)
Entrez Gene18976 (Evidence)
UniGene277996
DFCITC1574394, TC1584844
DoTSDT.87028350, DT.87073255, DT.97359596, DT.99861914
NIA Mouse Gene IndexU013711
Consensus CDS ProjectCCDS25785.1
International Mouse Knockout Project StatusPomc
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020660 Ensembl Gene Model | MGI Sequence Detail 5668 C57BL/6J ±  kb
transcript ENSMUST00000020990 Ensembl | MGI Sequence Detail 1007 Not Applicable 
polypeptide ENSMUSP00000020990 Ensembl | MGI Sequence Detail 235 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(10) UniProt(1)
Polymorphisms
RFLP(7) : SNPs within 2kb(63 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013532 Opiodes neuropeptide
InterPro IPR001941 Pro-opiomelanocortin/corticotropin, ACTH
InterPro IPR013531 Pro-opiomelanocortin/corticotropin, ACTH, central region
InterPro IPR013593 Pro-opiomelanocortin N-terminal
Protein Ontology PR:000013015 pro-opiomelanocortin
References
(Earliest) J:21792 Civelli O, et al., Detection and quantitation of pro-opiomelanocortin mRNA in pituitary and brain tissues from different species. J Biol Chem. 1982 Jun 25;257(12):6783-7
(Latest) J:208259 Yoder JM, et al., Phase-dependent resetting of the adrenal clock by ACTH in vitro. Am J Physiol Regul Integr Comp Physiol. 2014 Mar 15;306(6):R387-93
All references(257)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-13580, MGD-MRK-13582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory