Rr594 Other Genome Feature Detail

Summary

• Symbol
  Rr594
• Name
  regulatory region 594
• Synonyms
  nPE3

• Feature Type
  enhancer
• IDs
  MGI:7852691
• Regulates expression of
  Pomc (1 regulated gene)

Location &
Maps

• Sequence Map
  Chr12:3986524-3987162 bp

  From MGI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI
• J:357475: chr12:3936524-3937162 (GRCm38) chr12:3986524-3987162 (GRCm39)

• Genetic Map
  Chromosome 12, Syntenic

Strain
Comparison

• SNPs within 2kb
  105 from dbSNP Build 142

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  8 phenotypes from multigenic genotypes
  1 phenotype reference
  

• All Mutations and Alleles
  2
• Endonuclease-mediated
  2
• Find Mice (IMSR)
  0 strains or lines available

References

• Summaries
  All 2

  Phenotypes 1
• Earliest
  J:357475 Rojo D, et al., A mammalian tripartite enhancer cluster controls hypothalamic Pomc expression, food intake, and body weight. Proc Natl Acad Sci U S A. 2024 Apr 30;121(18):e2322692121

Rr594 regulates expression of:

Feature	Feature Type	Location	Reference
Pomc, pro-opiomelanocortin-alpha	protein coding gene	Chr12:4004951-4010642 (+)	J:357475