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Plcb1
Gene Detail
 Symbol
Name
ID
Plcb1
phospholipase C, beta 1
MGI:97613
STS D2Hss1
Synonyms 3110043I21Rik, mKIAA0581
Feature Type protein coding gene
Genetic Map
Chromosome 2
65.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr2:134786159-135475258 bp, + strand
From VEGA annotation of GRCm38

  689100 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22876  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta
Gene Tree: Plcb1

Human
homologs
Human Homolog PLCB1, phospholipase C, beta 1 (phosphoinositide-specific)
NCBI Gene ID 23236
neXtProt AC  NX_Q9NQ66
Human Synonyms  EIEE12, PI-PLC, PLC154, PLC-154, PLCB1A, PLCB1B, PLC-I
Human Chr (Location)  20p12; chr20:8132265-8884900 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLCB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Radiation induced(1) Targeted(2) Transgenic(1)
Genomic Mutations involving Plcb1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit spontaneous seizures and high mortality around 3 weeks of age. Mutant males show exhibit sperm with a reduced acrosome reaction rate and fertilizing capacity in vitro and decreased fertility in vivo.
 
Human Diseases Modeled Using Mouse Plcb1 (2)    Alleles Annotated to Human Diseases(2)   
Interactions
Plcb1 interacts with 436 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (67 annotations)
Process activation of meiosis involved in egg activation, brain development, ...
Component cytoplasm, cytosol, ...
Function calcium ion binding, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (165)    Tissues (155)    Images (21)
Theiler Stages: 2, 22, 23, 28
Assay TypeResults
RNA in situ 118
RT-PCR 47
cDNA source data(44)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) cDNA(45) Primer pair(3) Other(2)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000015592 (Evidence)
Ensembl Gene ModelENSMUSG00000051177 (Evidence)
Entrez Gene18795 (Evidence)
UniGene330607
DFCITC1579823, TC1591416, TC1617399, TC1641469
DoTSDT.101409861, DT.55283316, DT.91281675, DT.94239846, DT.94311219, DT.94361175
NIA Mouse Gene IndexU002517
EC3.1.4.11
Consensus CDS ProjectCCDS16787.1, CCDS50729.1
International Mouse Knockout Project StatusPlcb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015592 VEGA Gene Model | MGI Sequence Detail 689100 C57BL/6J ±  kb
transcript OTTMUST00000037031 VEGA | MGI Sequence Detail 7003 Not Applicable 
polypeptide OTTMUSP00000016610 VEGA | MGI Sequence Detail 1216 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(6) UniProt(3)
Polymorphisms RFLP(4) : SNPs within 2kb(5028 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR011992 EF-hand-like domain
InterPro IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
InterPro IPR009535 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site
InterPro IPR001192 Phosphoinositide phospholipase C
InterPro IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
InterPro IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
InterPro IPR014815 PLC-beta, C-terminal
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000012828 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
References (Earliest) J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
(Latest) J:184159 Antypa M, et al., Differential gene expression in migratory streams of cortical interneurons. Eur J Neurosci. 2011 Nov;34(10):1584-94
All references(88)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-13351, MGI:1920444, MGI:2138844

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory