Plcb1
Gene Detail

Symbol Name ID

Plcb1 phospholipase C, beta 1 MGI:97613

STS

D2Hss1

Synonyms

3110043I21Rik, mKIAA0581

Feature Type

protein coding gene

Genetic Map

Chromosome 2

65.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr2:134786159-135475258 bp, + strand From VEGA annotation of GRCm38   689100 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Plcb1 ± 2 cM)

Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta
Gene Tree: Plcb1

Human ortholog

PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) NCBI Gene ID 23236
Human Synonyms: EIEE12, PI-PLC, PLC154, PLC-154, PLCB1A, PLCB1B, PLC-I
Human Chr20:8113296-8865547 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human PLCB1 (1)

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(1) Transgenic(1)
 

Homozygotes for a targeted null mutation exhibit spontaneous seizures and high mortality around 3 weeks of age. Mutant males show exhibit sperm with a reduced acrosome reaction rate and fertilizing capacity in vitro and decreased fertility in vivo.

 
Human Diseases Modeled Using Mouse Plcb1 (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (65 annotations)

Process	activation of meiosis involved in egg activation, brain development, ...
Component	cytoplasm, cytosol, ...
Function	calcium ion binding, calmodulin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (165)    Tissues (155)    Images (21)
Theiler Stages: 2, 22, 23, 28

Assay Type	Results
RNA in situ	118
RT-PCR	47

cDNA source data(44)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(50) cDNA(45) Primer pair(3) Other(2)
Microarray probesets(10)

Other database links

VEGA Gene Model	OTTMUSG00000015592 (Evidence)
Ensembl Gene Model	ENSMUSG00000051177 (Evidence)
Entrez Gene	18795 (Evidence)
UniGene	330607
DFCI	TC1579823, TC1591416, TC1617399, TC1641469
DoTS	DT.101409861, DT.55283316, DT.91281675, DT.94239846, DT.94311219, DT.94361175
NIA Mouse Gene Index	U002517
EC	3.1.4.11
Consensus CDS Project	CCDS16787.1, CCDS50729.1
International Mouse Knockout Project Status	Plcb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015592	VEGA Gene Model | MGI Sequence Detail	689100	C57BL/6J
transcript	OTTMUST00000037031	VEGA | MGI Sequence Detail	7003	Not Applicable
polypeptide	OTTMUSP00000016610	VEGA | MGI Sequence Detail	1216	Not Applicable

All sequences(59) RefSeq(4) UniProt(4)

Polymorphisms

RFLP(4) : SNPs(3856 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR016280	Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
InterPro	IPR009535	Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta, conserved site
InterPro	IPR001192	Phosphoinositide phospholipase C
InterPro	IPR000909	Phospholipase C, phosphatidylinositol-specific , X domain
InterPro	IPR001711	Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro	IPR015359	Phospholipase C, phosphoinositol-specific, EF-hand-like
InterPro	IPR014815	PLC-beta, C-terminal
InterPro	IPR017946	PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro	IPR011993	Pleckstrin homology-like domain
Protein Ontology	PR:000012828	1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1

References

(Earliest) J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
(Latest) J:184159 Antypa M, et al., Differential gene expression in migratory streams of cortical interneurons. Eur J Neurosci. 2011 Nov;34(10):1584-94
All references(88)

Other accession IDs

MGD-MRK-13351, MGI:1920444, MGI:2138844