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Plcb1
Gene Detail
Symbol

Name
ID
Plcb1
phospholipase C, beta 1
MGI:97613
STS
Synonyms
3110043I21Rik, mKIAA0581
Feature Type
protein coding gene
Genetic Map
Chromosome 2
65.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr2:134786067-135475258 bp, + strand
From VEGA annotation of GRCm38

  689192 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22876  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: PLCB1
Protein SuperFamily: 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta
Gene Tree: Plcb1

Human
homologs
PLCB1, phospholipase C, beta 1 (phosphoinositide-specific)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 23236
neXtProt AC: NX_Q9NQ66

Human Synonyms: EIEE12, PI-PLC, PLC154, PLC-154, PLCB1A, PLCB1B, PLC-I

Human Chr (Location): 20p12; chr20:8132254-8884900 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PLCB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Radiation induced(1) Targeted(2) Transgenic(1)
Genomic Mutations involving Plcb1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit spontaneous seizures and high mortality around 3 weeks of age. Mutant males show exhibit sperm with a reduced acrosome reaction rate and fertilizing capacity in vitro and decreased fertility in vivo.
 
Human Diseases Modeled in Mice Using Plcb1 (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(1)
Interactions
Plcb1 interacts with 436 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process activation of meiosis involved in egg activation, brain development, ...
Component cytoplasm, cytosol, ...
Function calcium ion binding, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (165)    Tissues (155)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 118
RT-PCR 47
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase plcb1    NEW 
Molecular
reagents
All nucleic(51) cDNA(46) Primer pair(3) Other(2)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000015592 (Evidence)
Ensembl Gene Model ENSMUSG00000051177 (Evidence)
Entrez Gene 18795 (Evidence)
UniGene 330607
DFCI TC1579823, TC1591416, TC1617399, TC1641469
DoTS DT.101341004, DT.101409861, DT.55283316, DT.91281675, DT.94239846, DT.94311219, DT.94361175
NIA Mouse Gene Index U002517, U177573
EC 3.1.4.11
Consensus CDS Project CCDS16787.1, CCDS50729.1
International Mouse Phenotyping Consortium Status Plcb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015592 VEGA Gene Model | MGI Sequence Detail 689192 C57BL/6J ±  kb
transcript OTTMUST00000037031 VEGA | MGI Sequence Detail 7003 Not Applicable 
polypeptide OTTMUSP00000016610 VEGA | MGI Sequence Detail 1216 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(4) : SNPs within 2kb(5030 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR028400 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
InterPro IPR000008 C2 domain
InterPro IPR011992 EF-hand domain pair
InterPro IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
InterPro IPR000909 Phosphatidylinositol-specific phospholipase C, X domain
InterPro IPR001192 Phosphoinositide phospholipase C family
InterPro IPR015359 Phosphoinositide-specific phospholipase C, EF-hand-like domain
InterPro IPR009535 Phospholipase C-beta, conserved site
InterPro IPR014815 Phospholipase C-beta, C-terminal domain
InterPro IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
InterPro IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
InterPro IPR011993 Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)
Protein Ontology PR:000012828 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
References
(Earliest) J:30483 Hempel WM, et al., Expression of phospholipase C isozymes by murine B lymphocytes. J Immunol. 1991 Jun 1;146(11):3713-20
(Latest) J:184159 Antypa M, et al., Differential gene expression in migratory streams of cortical interneurons. Eur J Neurosci. 2011 Nov;34(10):1584-94
All references(88)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-13351, MGI:1920444, MGI:2138844

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory