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Prkca
Gene Detail
Symbol

Name
ID
Prkca
protein kinase C, alpha
MGI:97595
Synonyms
Pkca
Feature Type
protein coding gene
Genetic Map
Chromosome 11
70.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(37)
Sequence Map
Chr11:107933387-108343928 bp, - strand
From VEGA annotation of GRCm38

  410542 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55679  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: protein kinase C, alpha/beta/gamma types
Gene Tree: Prkca

Human
homologs
Human Homolog PRKCA, protein kinase C, alpha
NCBI Gene ID 5578
neXtProt AC  NX_P17252
Human Synonyms  AAG6, PKCA, PKC-alpha, PRKACA
Human Chr (Location)  17q22-q23.2; chr17:66302642-66810744 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(6) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show no overt macroscopic abnormalities, however examination of one line revealed increased cardiac muscle contractility and protection against heart failure.
 
Interactions
Prkca interacts with 479 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (102 annotations)
Process angiogenesis, apoptotic process, ...
Component apical part of cell, cell, ...
Function ATP binding, calcium-dependent protein kinase C activity, ...
External Resources: FuncBase
Expression
Literature Summary: (81 records)
Data Summary: Results (241)    Tissues (173)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 109
Western blot 26
RT-PCR 99
cDNA source data(71)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(82) cDNA(73) Primer pair(8) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000003131 (Evidence)
Ensembl Gene ModelENSMUSG00000050965 (Evidence)
Entrez Gene18750 (Evidence)
UniGene222178
DFCITC1581794, TC1591923, TC1597961
DoTSDT.110543235, DT.40185767, DT.97397898, DT.99854844
NIA Mouse Gene IndexU033564, U228381
EC2.7.11.13
Consensus CDS ProjectCCDS25573.1
International Mouse Knockout Project StatusPrkca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003131 VEGA Gene Model | MGI Sequence Detail 410542 C57BL/6J ±  kb
transcript OTTMUST00000006450 VEGA | MGI Sequence Detail 8409 Not Applicable 
polypeptide OTTMUSP00000003037 VEGA | MGI Sequence Detail 672 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(5) : SNPs within 2kb(2715 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR020454 Diacylglycerol/phorbol-ester binding
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR014375 Protein kinase C, alpha/beta/gamma types
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
InterPro IPR017892 Protein kinase, C-terminal
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000003058 protein kinase C alpha type
References
(Earliest) J:12309 Yang-Feng TL, et al., Protein kinase C genes in the mouse: Pkca maps to MMU 11 and Pkcc to MMU7. Cytogenet Cell Genet. 1987;46:723
(Latest) J:212370 Hill KS, et al., Protein kinase Calpha suppresses Kras-mediated lung tumor formation through activation of a p38 MAPK-TGFbeta signaling axis. Oncogene. 2014 Apr 17;33(16):2134-44
All references(261)
Other
accession IDs
MGD-MRK-13327, MGI:2144325

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory