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Prkaca
Gene Detail
Symbol

Name
ID
Prkaca
protein kinase, cAMP dependent, catalytic, alpha
MGI:97592
Synonyms
C alpha, Cs, PKA, Pkaca
Feature Type
protein coding gene
Genetic Map
Chromosome 8
40.22 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:83972978-83996444 bp, + strand
From NCBI annotation of GRCm38

  23467 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121574  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRKACA
Protein SuperFamily: kinase-related transforming protein
Gene Tree: Prkaca

Human
homologs
PRKACA, protein kinase, cAMP-dependent, catalytic, alpha
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5566
neXtProt AC: NX_P17612

Human Synonyms: PKACA, PPNAD4

Human Chr (Location): 19p13.1; chr19:14091688-14117747 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PRKACA

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutant mice are highly susceptible to perinatal lethality. Surviving mice are runted and while spermatogenesis progresses normally, mature sperm shows impaired motility.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(2)
Interactions
Prkaca interacts with 144 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (195)    Tissues (160)    Images (40)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 122
Northern blot 3
Western blot 4
RT-PCR 57
cDNA source data(124)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prkaca ; ZFIN prkacab    NEW 
Molecular
reagents
All nucleic(131) Genomic(3) cDNA(124) Primer pair(4)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000005469 (Evidence)
Entrez Gene 18747 (Evidence)
UniGene 19111
DFCI TC1586161, TC1637883, TC1656824, TC1712115, TC1730617, TC1777159
DoTS DT.110851847, DT.110851851, DT.110851854, DT.535374, DT.91341731, DT.94255968, DT.94263558
NIA Mouse Gene Index U009562, U066055
EC 2.7.11.11
PDB 1APM, 1ATP, 1BKX, 1BX6, 1FMO, 1J3H, 1JBP, 1JLU, 1L3R, 1PVK, 1RDQ, 1RE8, 1REJ, 1REK, 1SYK, 2CPK, 2ERZ, 2QCS, 2QUR, 2QVS, 3FHI, 3FJQ, 3IDB, 3IDC, 3J4Q, 3J4R, 3O7L, 3OW3, 3PVB, 3QAL, 3QAM, 3TNP, 3TNQ, 4DFX, 4DFY, 4DFZ, 4DG0, 4DG2, 4DG3, 4DH1, 4DH3, 4DH5, 4DH7, 4DH8, 4DIN, 4HPT, 4HPU, 4IAC, 4IAD, 4IAF, 4IAI, 4IAK, 4IAY, 4IAZ, 4IB0, 4IB1, 4IB3, 4NTS, 4NTT, 4O21, 4O22, 4WBB, 4XW4, 4XW5, 4XW6
Consensus CDS Project CCDS22463.1
International Mouse Phenotyping Consortium Status Prkaca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18747 NCBI Gene Model | MGI Sequence Detail 23467 C57BL/6J ±  kb
transcript NM_008854 RefSeq | MGI Sequence Detail 2300 C57BL/6 
polypeptide P05132 UniProt | EBI | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013222 cAMP-dependent protein kinase catalytic subunit alpha
Graphical View of Protein Domain Structure
References
(Earliest) J:25675 Uhler MD, et al., Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1300-4
(Latest) J:218384 Pollak NM, et al., The interplay of protein kinase a and perilipin 5 regulates cardiac lipolysis. J Biol Chem. 2015 Jan 16;290(3):1295-306
All references(118)
Other
accession IDs
MGD-MRK-13323

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory