Prkaca
Gene Detail

Symbol Name ID

Prkaca protein kinase, cAMP dependent, catalytic, alpha MGI:97592

Synonyms

C alpha, Cs, PKA, Pkaca

Feature Type

protein coding gene

Genetic Map

Chromosome 8

40.22 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr8:83972978-83996445 bp, + strand From NCBI annotation of GRCm38   23468 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:121574  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Prkaca

Human homologs

Human Homolog		PRKACA, protein kinase, cAMP-dependent, catalytic, alpha
NCBI Gene ID		5566
neXtProt AC		NX_P17612
Human Synonyms		PKACA
Human Chr (Location)		19p13.1; chr19:14202500-14228559 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(4) Gene trapped(2)
 

Homozygous mutant mice are highly susceptible to perinatal lethality. Surviving mice are runted and while spermatogenesis progresses normally, mature sperm shows impaired motility.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (53 annotations)

Process	cellular response to glucose stimulus, cellular response to parathyroid hormone stimulus, ...
Component	cAMP-dependent protein kinase complex, centrosome, ...
Function	ATP binding, cAMP-dependent protein kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (199)    Tissues (161)    Images (40)
Theiler Stages: 1, 2, 3, 4, 5, 20, 21, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	9
RNA in situ	122
Northern blot	3
Western blot	4
RT-PCR	61

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(3) cDNA(14) Primer pair(4)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000005469 (Evidence)
Entrez Gene	18747 (Evidence)
DFCI	TC1586161, TC1637883, TC1656824, TC1712115, TC1730617, TC1777159
DoTS	DT.110851847, DT.110851851, DT.110851854, DT.535374, DT.91341731, DT.94255968, DT.94263558
NIA Mouse Gene Index	U009562, U066055
EC	2.7.11.11
PDB	1APM, 1ATP, 1BKX, 1FMO, 1J3H, 1JBP, 1JLU, 1L3R, 1PVK, 1RDQ, 1REJ, 1REK, 1SYK, 2CPK, 2ERZ, 2QCS, 2QUR, 2QVS, 3FHI, 3FJQ, 3IDB, 3IDC, 3O7L, 3PVB, 3QAL, 3QAM, 4DFX, 4DFY, 4DFZ, 4DIN, 1BX6, 1RE8, 3OW3, 4DG0, 4DG2, 4DH1, 4DH3, 4DH5, 4DH7, 4DH8
Consensus CDS Project	CCDS22463.1
International Mouse Knockout Project Status	Prkaca

Sequences

Length	Strain/Species
genomic	18747	NCBI Gene Model | MGI Sequence Detail	23468	C57BL/6J
transcript	NM_008854	RefSeq | MGI Sequence Detail	2300	C57BL/6
polypeptide	P05132	UniProt | EBI | MGI Sequence Detail	351	Not Applicable

All sequences(52) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(65 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000013222	cAMP-dependent protein kinase catalytic subunit alpha

Graphical View of Protein Domain Structure

References

(Earliest) J:25675 Uhler MD, et al., Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1300-4
(Latest) J:192113 Blasic JR Jr, et al., Phosphorylation of mouse melanopsin by protein kinase A. PLoS One. 2012;7(9):e45387
All references(106)

Other accession IDs

MGD-MRK-13323