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Prkaca Gene Detail
Summary
  • Symbol
    Prkaca
  • Name
    protein kinase, cAMP dependent, catalytic, alpha
  • Synonyms
    C alpha, Cs, PKA, Pkaca
  • Feature Type
    protein coding gene
  • IDs
    MGI:97592
    NCBI Gene: 18747
  • Gene Overview
    MyGene.info: PRKACA
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:83972993-83996443 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 40.22 cM, cytoband C3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97592
protein coding gene Chr8:83972978-83996444 (.)
129S1/SvImJ MGP_129S1SvImJ_G0033844
protein coding gene Chr8:84833724-84858129 (+)
A/J MGP_AJ_G0033827
protein coding gene Chr8:81513238-81536514 (+)
AKR/J MGP_AKRJ_G0033753
protein coding gene Chr8:83918480-83946803 (+)
BALB/cJ MGP_BALBcJ_G0033820
protein coding gene Chr8:81619461-81642570 (+)
C3H/HeJ MGP_C3HHeJ_G0033530
protein coding gene Chr8:84531531-84554710 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034340
protein coding gene Chr8:88074941-88104283 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031282
protein coding gene Chr8:75313946-75337298 (+)
CAST/EiJ MGP_CASTEiJ_G0032860
protein coding gene Chr8:83945392-83971854 (+)
CBA/J MGP_CBAJ_G0033506
protein coding gene Chr8:91207733-91231500 (+)
DBA/2J MGP_DBA2J_G0033661
protein coding gene Chr8:81150654-81173587 (+)
FVB/NJ MGP_FVBNJ_G0033607
protein coding gene Chr8:80072645-80096297 (+)
LP/J MGP_LPJ_G0033751
protein coding gene Chr8:84948350-84972806 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033649
protein coding gene Chr8:93709946-93734471 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034357
protein coding gene Chr8:83896358-83920637 (+)
PWK/PhJ MGP_PWKPhJ_G0032564
protein coding gene Chr8:80371623-80395579 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032401
protein coding gene Chr8:82710178-82733280 (+)
WSB/EiJ MGP_WSBEiJ_G0032973
protein coding gene Chr8:84306768-84333616 (+)



Homology
more
  • Human Ortholog
    PRKACA, protein kinase cAMP-activated catalytic subunit alpha
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PRKACA, protein kinase cAMP-activated catalytic subunit alpha
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PKACA, PPNAD4
  • Links
    NCBI Gene ID: 5566
    neXtProt AC: NX_P17612
    UniProt: P17612

  • Chr Location
    19p13.12; chr19:14091688-14117747 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PRKACA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 5 alleles in 4 genetic backgrounds
    40 phenotypes from multigenic genotypes
    2 images
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice are highly susceptible to perinatal lethality. Surviving mice are runted and while spermatogenesis progresses normally, mature sperm shows impaired motility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000005469 Ensembl Gene Model | MGI Sequence Detail 23451 C57BL/6J ±  kb
    transcript ENSMUST00000005606 Ensembl | MGI Sequence Detail 2276 Not Applicable  
    polypeptide ENSMUSP00000005606 Ensembl | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 132
      Genomic 3
      cDNA 125
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13323
    References
    more
    • Summaries
      All 226
      Developmental Gene Expression 16
      Diseases 2
      Gene Ontology 41
      Phenotypes 62
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
    • Latest
      J:266142 Grosjean F, et al., Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice. PLoS One. 2018;13(9):e0204366

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory