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Prkaca
Gene Detail
 Symbol
Name
ID
Prkaca
protein kinase, cAMP dependent, catalytic, alpha
MGI:97592
Synonyms C alpha, Cs, PKA, Pkaca
Feature Type protein coding gene
Genetic Map
Chromosome 8
40.22 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr8:83972978-83996445 bp, + strand
From NCBI annotation of GRCm38

  23468 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:121574  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 dog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Prkaca

Human
homologs
Human Homolog PRKACA, protein kinase, cAMP-dependent, catalytic, alpha
NCBI Gene ID 5566
neXtProt AC  NX_P17612
Human Synonyms  PKACA
Human Chr (Location)  19p13.1; chr19:14091688-14117747 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(4) Gene trapped(2)
 
Homozygous mutant mice are highly susceptible to perinatal lethality. Surviving mice are runted and while spermatogenesis progresses normally, mature sperm shows impaired motility.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (65 annotations)
Process cellular response to glucose stimulus, cellular response to parathyroid hormone stimulus, ...
Component AMP-activated protein kinase complex, cAMP-dependent protein kinase complex, ...
Function ATP binding, cAMP-dependent protein kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (199)    Tissues (161)    Images (40)
Theiler Stages: 1, 2, 3, 4, 5, 20, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 122
Northern blot 3
Western blot 4
RT-PCR 61
cDNA source data(124)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(131) Genomic(3) cDNA(124) Primer pair(4)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000005469 (Evidence)
Entrez Gene18747 (Evidence)
UniGene19111
DFCITC1586161, TC1637883, TC1656824, TC1712115, TC1730617, TC1777159
DoTSDT.110851847, DT.110851851, DT.110851854, DT.535374, DT.91341731, DT.94255968, DT.94263558
NIA Mouse Gene IndexU009562, U066055
EC2.7.11.11
PDB1APM, 1ATP, 1BKX, 1FMO, 1J3H, 1JBP, 1JLU, 1L3R, 1PVK, 1RDQ, 1REJ, 1REK, 1SYK, 2CPK, 2ERZ, 2QCS, 2QUR, 2QVS, 3FHI, 3FJQ, 3IDB, 3IDC, 3J4Q, 3J4R, 3O7L, 3PVB, 3QAL, 3QAM, 4DFX, 4DFY, 4DFZ, 4DIN, 4HPT, 4HPU, 4IAC, 4IAD, 4IAF, 4IAI, 4IAK, 4IAY, 4IAZ, 1BX6, 1RE8, 3OW3, 4DG0, 4DG2, 4DG3, 4DH1, 4DH3, 4DH5, 4DH7, 4DH8, 4IB0, 4IB1, 4IB3
Consensus CDS ProjectCCDS22463.1
International Mouse Knockout Project StatusPrkaca
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18747 NCBI Gene Model | MGI Sequence Detail 23468 C57BL/6J ±  kb
transcript NM_008854 RefSeq | MGI Sequence Detail 2300 C57BL/6 
polypeptide P05132 UniProt | EBI | MGI Sequence Detail 351 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(143 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000013222 cAMP-dependent protein kinase catalytic subunit alpha
Graphical View of Protein Domain Structure
References (Earliest) J:25675 Uhler MD, et al., Isolation of cDNA clones coding for the catalytic subunit of mouse cAMP-dependent protein kinase. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1300-4
(Latest) J:206832 Parisiadou L, et al., LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Nat Neurosci. 2014 Mar;17(3):367-76
All references(112)
Other
accession IDs
MGD-MRK-13323

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory