Gene Expression Literature Summary

• Symbol: Prkaca
• Name: protein kinase, cAMP dependent, catalytic, alpha
• ID: MGI:97592

23 matching records from 23 references.

Summary by Age and Assay: Numbers in the table indicate the number of results matching the search criteria.

Age	E0.5	E1	E2	E2.5	E3	E3.5	E4	E9.5	E10.5	E11.5	E12	E12.5	E13.5	E14	E14.5	E15	E15.5	E16	E16.5	E18	E18.5	E19	P
Immunohistochemistry (section)								1	1										1				1
In situ RNA (section)										1	1		1	2	2		1	1		1	1		3
Immunohistochemistry (whole mount)	1	1	1		1	1	1																1
Northern blot												1	1		1
Western blot								1	1	2		1	1		1		1				2		6
RT-PCR	1	1		1	1	1	1									1		1				1	6

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Prkaca  protein kinase, cAMP dependent, catalytic, alpha   (Synonyms: C alpha, Cs, PKA, Pkaca)
Results	Reference
1	J:309666 Balta EA, Schaffner I, Wittmann MT, Sock E, von Zweydorf F, von Wittgenstein J, Steib K, Heim B, Kremmer E, Haberle BM, Ueffing M, Lie DC, Gloeckner CJ, Phosphorylation of the neurogenic transcription factor SOX11 on serine 133 modulates neuronal morphogenesis. Sci Rep. 2018 Nov 1;8(1):16196
2	J:244906 Berthon A, Faucz FR, Espiard S, Drougat L, Bertherat J, Stratakis CA, Age-dependent effects of Armc5 haploinsufficiency on adrenocortical function. Hum Mol Genet. 2017 Sep 15;26(18):3495-3507
2*	J:280416 Cadd G, McKnight GS, Distinct patterns of cAMP-dependent protein kinase gene expression in mouse brain. Neuron. 1989 Jul;3(1):71-9
6*	J:228948 Deak VA, Skroblin P, Dittmayer C, Knobeloch KP, Bachmann S, Klussmann E, The A-kinase Anchoring Protein GSKIP Regulates GSK3beta Activity and Controls Palatal Shelf Fusion in Mice. J Biol Chem. 2016 Jan 8;291(2):681-90
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:94148 Frederikse PH, Yun E, Kao HT, Zigler JS Jr, Sun Q, Qazi AS, Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation. Mol Vis. 2004 Oct 25;10:794-804
3*	J:46439 Freeman TC, Dixon AK, Campbell EA, Tait TM, Richardson PJ, Rice KM, Maslen GL, Metcalfe AD, Streuli CH, Bentley DR, Expression Mapping of Mouse Genes. MGI Direct Data Submission. 1998;
3*	J:25553 Greene RM, Lloyd MR, Uberti M, Nugent P, Pisano MM, Patterns of cyclic AMP-dependent protein kinase gene expression during ontogeny of the murine palate. J Cell Physiol. 1995 Jun;163(3):431-40
1	J:76765 Huang Y, Roelink H, McKnight GS, Protein kinase A deficiency causes axially localized neural tube defects in mice. J Biol Chem. 2002 May 31;277(22):19889-96
7*	J:35122 Imaizumi-Scherrer T, Faust DM, Benichou JC, Hellio R, Weiss MC, Accumulation in fetal muscle and localization to the neuromuscular junction of cAMP-dependent protein kinase A regulatory and catalytic subunits RI alpha and C alpha. J Cell Biol. 1996 Sep;134(5):1241-54
1*	J:157948 Jiang XS, Wassif CA, Backlund PS, Song L, Holtzclaw LA, Li Z, Yergey AL, Porter FD, Activation of Rho GTPases in Smith-Lemli-Opitz syndrome: pathophysiological and clinical implications. Hum Mol Genet. 2010 Apr 1;19(7):1347-57
1	J:336227 Karatsai O, Lehka L, Wojton D, Grabowska AI, Duda MK, Lenartowski R, Redowicz MJ, Unconventional myosin VI in the heart: Involvement in cardiac dysfunction progressing with age. Biochim Biophys Acta Mol Basis Dis. 2023 Aug;1869(6):166748
1	J:333724 Park EJ, Kim HS, Lee DH, Kim SM, Yoon JS, Lee JM, Im SJ, Lee H, Lee MW, Lee CW, Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nat Commun. 2023 Feb 25;14(1):1097
1	J:320677 Piazzon N, Maisonneuve C, Guilleret I, Rotman S, Constam DB, Bicc1 links the regulation of cAMP signaling in polycystic kidneys to microRNA-induced gene silencing. J Mol Cell Biol. 2012 Dec;4(6):398-408
1	J:286471 Testini C, Smith RO, Jin Y, Martinsson P, Sun Y, Hedlund M, Sainz-Jaspeado M, Shibuya M, Hellstrom M, Claesson-Welsh L, Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2. EMBO Rep. 2019 Nov 5;20(11):e47845
5*	J:215487 Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JL, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A,Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR, A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Neuron. 2014 Jul 16;83(2):309-23
1	J:121697 Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA, Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar;13(3):324-31
2	J:181006 Tuson M, He M, Anderson KV, Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube. Development. 2011 Nov;138(22):4921-30
2*	J:126153 Ulucan C, Wang X, Baljinnyam E, Bai Y, Okumura S, Sato M, Minamisawa S, Hirotani S, Ishikawa Y, Developmental changes in gene expression of Epac and its upregulation in myocardial hypertrophy. Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1662-72
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
14*	J:186779 Yamamizu K, Fujihara M, Tachibana M, Katayama S, Takahashi A, Hara E, Imai H, Shinkai Y, Yamashita JK, Protein kinase A determines timing of early differentiation through epigenetic regulation with G9a. Cell Stem Cell. 2012 Jun 14;10(6):759-70
1	J:142482 Yin Z, Jones GN, Towns WH 2nd, Zhang X, Abel ED, Binkley PF, Jarjoura D, Kirschner LS, Heart-specific ablation of Prkar1a causes failure of heart development and myxomagenesis. Circulation. 2008 Mar 18;117(11):1414-22
1	J:311150 Zhang Y, Hao J, Tarrago MG, Warner GM, Giorgadze N, Wei Q, Huang Y, He K, Chen C, Peclat TR, White TA, Ling K, Tchkonia T, Kirkland JL, Chini EN, Hu J, FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue. Cell Rep. 2021 Aug 3;36(5):109481