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Abcb1b Gene Detail
Summary
  • Symbol
    Abcb1b
  • Name
    ATP-binding cassette, sub-family B member 1B
  • Synonyms
    Abcb1, mdr, Mdr1, Mdr1b, Pgy1, Pgy-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97568
    NCBI Gene: 18669
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:8848147-8916314 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 3.43 cM, cytoband A2-A3
  • Mapping Data
    27 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1101 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    6
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97568
 protein coding gene Chr5:8848147-8916315 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029287
 protein coding gene Chr5:5781307-5854152 (+)
A/J MGP_AJ_G0029250
 protein coding gene Chr5:5634381-5704954 (+)
AKR/J MGP_AKRJ_G0029199
 protein coding gene Chr5:5723492-5792714 (+)
BALB/cJ MGP_BALBcJ_G0029267
 protein coding gene Chr5:5815646-5886573 (+)
C3H/HeJ MGP_C3HHeJ_G0028987
 protein coding gene Chr5:5881936-6023977 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029717
 protein coding gene Chr5:6305692-6390854 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026960
 protein coding gene Chr5:5282976-5443694 (+)
CAST/EiJ MGP_CASTEiJ_G0028400
 protein coding gene Chr5:5680655-5840940 (+)
CBA/J MGP_CBAJ_G0028948
 protein coding gene Chr5:6453961-6532845 (+)
DBA/2J MGP_DBA2J_G0029102
 protein coding gene Chr5:5746209-5816205 (+)
FVB/NJ MGP_FVBNJ_G0029064
 protein coding gene Chr5:5500144-5569249 (+)
LP/J MGP_LPJ_G0029191
 protein coding gene Chr5:5906515-5994088 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029092
 protein coding gene Chr5:6444585-6519487 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029748
 protein coding gene Chr5:5714023-5788490 (+)
PWK/PhJ MGP_PWKPhJ_G0028122
 protein coding gene Chr5:5425840-5594505 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027955
 protein coding gene Chr5:5807962-5969938 (+)
WSB/EiJ MGP_WSBEiJ_G0028480
 protein coding gene Chr5:5664816-5816670 (+)



Homology
more
  • Human Ortholog
    ABCB1, ATP binding cassette subfamily B member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ABCB1, ATP binding cassette subfamily B member 1
  • Synonyms
    ABC20, CD243, CLCS, GP170, MDR1, p-170, P-GP, PGY1
  • Links
    NCBI Gene ID: 5243
    neXtProt AC: NX_P08183
    UniProt: P08183

  • Chr Location
    7q21.12; chr7:87503017-87713323 (-)  GRCh38
Human Diseases
more
  • Diseases
    27 with human ABCB1 associations

Human Disease Mouse Models
      
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 View 1 model
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    8 phenotypes from multigenic genotypes
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted mutations that inactivate the gene are hypersensitive to effects of drugs transported by phosphoglycoproteins.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    50
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    862
  • Tissues
    138
  • cDNA Data
    18
  • Literature Summary
    13
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18669 NCBI Gene Model | MGI Sequence Detail 68168 C57BL/6J ±  kb
transcript NM_011075 RefSeq | MGI Sequence Detail 4344 ZRU/MplStud  
polypeptide P06795 UniProt | EBI | MGI Sequence Detail 1276 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 50
    Genomic 16
    cDNA 30
    Primer pair 3
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12177, MGD-MRK-13283, MGD-MRK-13286
References
more
  • Summaries
    All 212
    Developmental Gene Expression 13
    Gene Ontology 11
    Phenotypes 82
  • Earliest
    J:8147 Gros P, et al., Isolation and characterization of DNA sequences amplified in multidrug-resistant hamster cells. Proc Natl Acad Sci U S A. 1986 Jan;83(2):337-41
  • Latest
    J:312727 Zawatsky CN, et al., Peripheral Hybrid CB1R and iNOS Antagonist MRI-1867 Displays Anti-Fibrotic Efficacy in Bleomycin-Induced Skin Fibrosis. Front Endocrinol (Lausanne). 2021;12:744857
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory