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Pgr
Gene Detail
 Symbol
Name
ID
Pgr
progesterone receptor
MGI:97567
Synonyms 9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-A, PR-B
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:8900419-8965425 bp, + strand
From VEGA annotation of GRCm38

  65007 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:713  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: progesterone receptor
Gene Tree: Pgr

Human
homologs
Human Homolog PGR, progesterone receptor
NCBI Gene ID 5241
neXtProt AC  NX_P06401
Human Synonyms  NR3C3, PR
Human Chr (Location)  11q22-q23; chr11:101029624-101129813 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PGR
Alleles
and
phenotypes
All alleles(14) : Targeted(14)
 
Null female mice are sterile and exhibit ovulatory defects, uterine hyperplasia, and impaired mammary development. Females lacking only isoform A are infertile but show normal mammary development, while females lacking only isoform B are fertile but present with mammary developmental defects.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process epithelial cell maturation, female mating behavior, ...
Component axon, axon terminus, ...
Function DNA binding, enzyme binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (94)    Tissues (55)    Images (7)
Theiler Stages: 16, 18, 21, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 87
RT-PCR 7
cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(21) Genomic(4) cDNA(16) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022998 (Evidence)
Ensembl Gene ModelENSMUSG00000031870 (Evidence)
Entrez Gene18667 (Evidence)
DFCITC1589136, TC1595996, TC1598023, TC1635777
DoTSDT.101351434, DT.101720817, DT.487429, DT.99852625
NIA Mouse Gene IndexU010032
Consensus CDS ProjectCCDS22816.1
International Mouse Knockout Project StatusPgr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022998 VEGA Gene Model | MGI Sequence Detail 65007 C57BL/6J ±  kb
transcript OTTMUST00000055387 VEGA | MGI Sequence Detail 3068 Not Applicable 
polypeptide OTTMUSP00000026522 VEGA | MGI Sequence Detail 926 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(4) UniProt(7)
Polymorphisms SNPs within 2kb(525 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR000128 Progesterone receptor
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000012621 progesterone receptor
References (Earliest) J:12501 Naylor SL, et al., The progesterone receptor gene is on mouse Chromosome 9. Cytogenet Cell Genet. 1989;51:1051
(Latest) J:204184 Kommagani R, et al., Acceleration of the glycolytic flux by steroid receptor coactivator-2 is essential for endometrial decidualization. PLoS Genet. 2013 Oct;9(10):e1003900
All references(184)
Other
accession IDs
MGD-MRK-13282, MGI:2143361, MGI:2444097, MGI:3642750

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory