Pgr
Gene Detail

Symbol Name ID

Pgr progesterone receptor MGI:97567

Synonyms

9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-A, PR-B

Feature Type

protein coding gene

Genetic Map

Chromosome 9

2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:8900419-8965425 bp, + strand From VEGA annotation of GRCm38   65007 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:713  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: progesterone receptor
Gene Tree: Pgr

Human homologs

Human Homolog		PGR, progesterone receptor
NCBI Gene ID		5241
neXtProt AC		NX_P06401
Human Synonyms		NR3C3, PR
Human Chr (Location)		11q22-q23; chr11:100900355-101000544 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PGR

Alleles and phenotypes

All alleles(12) : Targeted(12)
 

Null female mice are sterile and exhibit ovulatory defects, uterine hyperplasia, and impaired mammary development. Females lacking only isoform A are infertile but show normal mammary development, while females lacking only isoform B are fertile but present with mammary developmental defects.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (35 annotations)

Process	epithelial cell maturation, intracellular receptor signaling pathway, ...
Component	cytoplasm, cytosol, ...
Function	DNA binding, enzyme binding, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (94)    Tissues (55)    Images (7)
Theiler Stages: 16, 18, 21, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	87
RT-PCR	7

cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(4) cDNA(16) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000022998 (Evidence)
Ensembl Gene Model	ENSMUSG00000031870 (Evidence)
Entrez Gene	18667 (Evidence)
DFCI	TC1589136, TC1595996, TC1598023, TC1635777
DoTS	DT.101351434, DT.101720817, DT.487429, DT.99852625
NIA Mouse Gene Index	U010032
Consensus CDS Project	CCDS22816.1
International Mouse Knockout Project Status	Pgr

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022998	VEGA Gene Model | MGI Sequence Detail	65007	C57BL/6J
transcript	OTTMUST00000055387	VEGA | MGI Sequence Detail	3068	Not Applicable
polypeptide	OTTMUSP00000026522	VEGA | MGI Sequence Detail	926	Not Applicable

All sequences(42) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(549 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008946	Nuclear hormone receptor, ligand-binding
InterPro	IPR000536	Nuclear hormone receptor, ligand-binding, core
InterPro	IPR000128	Progesterone receptor
InterPro	IPR001723	Steroid hormone receptor
InterPro	IPR013088	Zinc finger, NHR/GATA-type
InterPro	IPR001628	Zinc finger, nuclear hormone receptor-type
Protein Ontology	PR:000012621	progesterone receptor

References

(Earliest) J:12501 Naylor SL, et al., The progesterone receptor gene is on mouse Chromosome 9. Cytogenet Cell Genet. 1989;51:1051
(Latest) J:195226 van der Zee M, et al., Alterations in Wnt-beta-catenin and Pten signalling play distinct roles in endometrial cancer initiation and progression. J Pathol. 2013 May;230(1):48-58
All references(172)

Other accession IDs

MGD-MRK-13282, MGI:2143361, MGI:2444097, MGI:3642750