About   Help   FAQ
Pgr Gene Detail
Summary
  • Symbol
    Pgr
  • Name
    progesterone receptor
  • Synonyms
    9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-A, PR-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:97567
    NCBI Gene: 18667
  • Gene Overview
    MyGene.info: PGR
Location & Maps
more
Homology
more
  • Human Ortholog
    PGR, progesterone receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PGR, progesterone receptor
    Orthology source: HomoloGene
  • Synonyms
    NR3C3, PR
  • Links
    NCBI Gene ID: 5241
    neXtProt AC: NX_P06401

  • Chr Location
    11q22-q23; chr11:101029624-101130668 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PGR associations

Human Disease Mouse Models
       Progesterone Resistance   OMIM: 264080
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 10 alleles in 10 genetic backgrounds
    39 phenotypes from multigenic genotypes
    3 images
    153 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Null female mice are sterile and exhibit ovulatory defects, uterine hyperplasia, and impaired mammary development. Females lacking only isoform A are infertile but show normal mammary development, while females lacking only isoform B are fertile but present with mammary developmental defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022998 VEGA Gene Model | MGI Sequence Detail 65007 C57BL/6J ±  kb
transcript OTTMUST00000055387 VEGA | MGI Sequence Detail 3068 Not Applicable  
polypeptide OTTMUSP00000026522 VEGA | MGI Sequence Detail 926 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    490 from dbSNP Build 142
Protein
Information
less
  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000012621 progesterone receptor
  • InterPro Domains
    IPR001723 Nuclear hormone receptor
    IPR000536 Nuclear hormone receptor, ligand-binding domain
    IPR000128 Progesterone receptor
    IPR013088 Zinc finger, NHR/GATA-type
    IPR001628 Zinc finger, nuclear hormone receptor-type
Molecular
Reagents
less
  • All nucleic 21
    Genomic 4
    cDNA 16
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-13282, MGI:2143361, MGI:2444097, MGI:3642750
References
more
  • Summaries
    All 214
    Developmental Gene Expression 19
    Diseases 5
    Gene Ontology 14
    Phenotypes 153
  • Earliest
    J:12501 Naylor SL, et al., The progesterone receptor gene is on mouse Chromosome 9. Cytogenet Cell Genet. 1989;51:1051
  • Latest
    J:229513 Shen J, et al., Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development. Oncotarget. 2016 Feb 17;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/26/2016
MGI 6.03
The Jackson Laboratory