About   Help   FAQ
Pgr Gene Detail
Summary
  • Symbol
    Pgr
  • Name
    progesterone receptor
  • Synonyms
    9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-A, PR-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:97567
    NCBI Gene: 18667
  • Gene Overview
    MyGene.info: PGR
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    PGR, progesterone receptor
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PGR, progesterone receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NR3C3, PR
  • Links
    NCBI Gene ID: 5241
    neXtProt AC: NX_P06401
    UniProt: P06401

  • Chr Location
    11q22.1; chr11:101029624-101130681 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 10 alleles in 10 genetic backgrounds
    59 phenotypes from multigenic genotypes
    3 images
    187 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null female mice are sterile and exhibit ovulatory defects, uterine hyperplasia, and impaired mammary development. Females lacking only isoform A are infertile but show normal mammary development, while females lacking only isoform B are fertile but present with mammary developmental defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000022998 VEGA Gene Model | MGI Sequence Detail 65007 C57BL/6J ±  kb
    transcript OTTMUST00000055387 VEGA | MGI Sequence Detail 3068 Not Applicable  
    polypeptide OTTMUSP00000026522 VEGA | MGI Sequence Detail 926 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      490 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 4
      cDNA 16
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13282, MGI:2143361, MGI:2444097, MGI:3642750
    References
    more
    • Summaries
      All 279
      Developmental Gene Expression 24
      Diseases 5
      Gene Ontology 15
      Phenotypes 187
    • Earliest
      J:12501 Naylor SL, et al., The progesterone receptor gene is on mouse Chromosome 9. Cytogenet Cell Genet. 1989;51:1051
    • Latest
      J:259690 Shroff A, et al., Knockout of autophagy gene, ATG5 in mice vaginal cells abrogates cytokine response and pathogen clearance during vaginal infection of Candida albicans. Cell Immunol. 2018 Feb;324:59-73

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory