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Pgr
Gene Detail
Symbol

Name
ID
Pgr
progesterone receptor
MGI:97567
Synonyms
9930019P03Rik, ENSMUSG00000074510, NR3C3, PR, PR-A, PR-B
Feature Type
protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:8900419-8965425 bp, + strand
From VEGA annotation of GRCm38

  65007 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:713  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: PGR
Protein SuperFamily: progesterone receptor
Gene Tree: Pgr

Human
homologs
PGR, progesterone receptor
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5241
neXtProt AC: NX_P06401

Human Synonyms: NR3C3, PR

Human Chr (Location): 11q22-q23; chr11:101029624-101130668 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PGR

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Targeted(15) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Null female mice are sterile and exhibit ovulatory defects, uterine hyperplasia, and impaired mammary development. Females lacking only isoform A are infertile but show normal mammary development, while females lacking only isoform B are fertile but present with mammary developmental defects.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Pgr interacts with 114 markers (Mir16-2, Mir19a, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (54 annotations)
Process epithelial cell maturation, female mating behavior, ...
Component axon, axon terminus, ...
Function ATPase binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (94)    Tissues (57)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 87
RT-PCR 7
cDNA source data(16)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase pgr ; ZFIN pgr    NEW 
Molecular
reagents
All nucleic(21) Genomic(4) cDNA(16) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000022998 (Evidence)
Ensembl Gene Model ENSMUSG00000031870 (Evidence)
Entrez Gene 18667 (Evidence)
DFCI TC1589136, TC1595996, TC1598023, TC1635777
DoTS DT.101351434, DT.101720817, DT.487429, DT.99852625
NIA Mouse Gene Index U010032
Consensus CDS Project CCDS22816.1
International Mouse Phenotyping Consortium Status Pgr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022998 VEGA Gene Model | MGI Sequence Detail 65007 C57BL/6J ±  kb
transcript OTTMUST00000055387 VEGA | MGI Sequence Detail 3068 Not Applicable 
polypeptide OTTMUSP00000026522 VEGA | MGI Sequence Detail 926 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(4) UniProt(7)
Polymorphisms
SNPs within 2kb(525 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008946 Nuclear hormone receptor, ligand-binding
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
InterPro IPR000128 Progesterone receptor
InterPro IPR001723 Steroid hormone receptor
InterPro IPR013088 Zinc finger, NHR/GATA-type
InterPro IPR001628 Zinc finger, nuclear hormone receptor-type
Protein Ontology PR:000012621 progesterone receptor
References
(Earliest) J:12501 Naylor SL, et al., The progesterone receptor gene is on mouse Chromosome 9. Cytogenet Cell Genet. 1989;51:1051
(Latest) J:222173 Solano ME, et al., Progesterone and HMOX-1 promote fetal growth by CD8+ T cell modulation. J Clin Invest. 2015 Apr;125(4):1726-38
All references(207)
Other
accession IDs
MGD-MRK-13282, MGI:2143361, MGI:2444097, MGI:3642750

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory