Pcx
Gene Detail

Symbol Name ID

Pcx pyruvate carboxylase MGI:97520

Synonyms

Pc

Feature Type

protein coding gene

Genetic Map

Chromosome 19

4.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr19:4510472-4621752 bp, + strand From NCBI annotation of GRCm38   111281 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5422  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Pcx

Human homologs

Human Homolog		PC, pyruvate carboxylase
NCBI Gene ID		5091
neXtProt AC		NX_P11498
Human Synonyms		PCB
Human Chr (Location)		11q13.4-q13.5; chr11:66615997-66725847 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PC

Alleles and phenotypes

All alleles(10) : Targeted(2) Gene trapped(8)

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	gluconeogenesis, lipid metabolic process, ...
Component	mitochondrial inner membrane, mitochondrion
Function	ATP binding, biotin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (200)    Tissues (108)    Images (39)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	200

cDNA source data(122)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(123) cDNA(122) Other(1)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000024892 (Evidence)
Entrez Gene	18563 (Evidence)
UniGene	1845
DFCI	TC1572598, TC1681214, TC1774910
DoTS	DT.101735924, DT.492968, DT.94373824, DT.94373829, DT.97354171
NIA Mouse Gene Index	U038745
EC	6.4.1.1
Consensus CDS Project	CCDS29430.1, CCDS50352.1
International Mouse Knockout Project Status	Pcx

Sequences

Length	Strain/Species
genomic	18563	NCBI Gene Model | MGI Sequence Detail	111281	C57BL/6J
transcript	NM_001162946	RefSeq | MGI Sequence Detail	4148	C57BL/6
polypeptide	Q05920	UniProt | EBI | MGI Sequence Detail	1178	Not Applicable

All sequences(54) RefSeq(4) UniProt(9)

Polymorphisms

SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013785	Aldolase-type TIM barrel
InterPro	IPR011761	ATP-grasp fold
InterPro	IPR013815	ATP-grasp fold, subdomain 1
InterPro	IPR013816	ATP-grasp fold, subdomain 2
InterPro	IPR001882	Biotin-binding site
InterPro	IPR005482	Biotin carboxylase, C-terminal
InterPro	IPR011764	Biotin carboxylation domain
InterPro	IPR000089	Biotin/lipoyl attachment
InterPro	IPR005481	Carbamoyl-phosphate synthase, large subunit, N-terminal
InterPro	IPR005479	Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
InterPro	IPR003379	Carboxylase, conserved domain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR016185	Pre-ATP-grasp domain
InterPro	IPR005930	Pyruvate carboxylase
InterPro	IPR000891	Pyruvate carboxyltransferase
InterPro	IPR011054	Rudiment single hybrid motif
InterPro	IPR011053	Single hybrid motif
Protein Ontology	PR:000012331	pyruvate carboxylase, mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:32775 Trigg M, New Mutations - provisional gene symbol act (adult cataract) and provisional gene symbol fp (flopsy). Mouse News Lett. 1972;47:19
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(46)

Other accession IDs

MGD-MRK-13166, MGD-MRK-13201