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Pcx
Gene Detail
Symbol

Name
ID
Pcx
pyruvate carboxylase
MGI:97520
Synonyms
Pc
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr19:4510472-4621752 bp, + strand
From NCBI annotation of GRCm38

  111281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5422  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Pcx

Human
homologs
Human Homolog PC, pyruvate carboxylase
NCBI Gene ID 5091
neXtProt AC  NX_P11498
Human Synonyms  PCB
Human Chr (Location)  11q13.4-q13.5; chr11:66848522-66958376 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PC
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(8) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Pcx interacts with 99 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process gluconeogenesis, lipid metabolic process, ...
Component mitochondrial inner membrane, mitochondrion
Function ATP binding, biotin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (200)    Tissues (108)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 200
cDNA source data(123)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(124) cDNA(123) Other(1)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000024892 (Evidence)
Entrez Gene18563 (Evidence)
UniGene1845
DFCITC1572598, TC1681214, TC1774910
DoTSDT.101735924, DT.492968, DT.94373824, DT.94373829, DT.97354171
NIA Mouse Gene IndexU038745
EC6.4.1.1
Consensus CDS ProjectCCDS29430.1, CCDS50352.1
International Mouse Knockout Project StatusPcx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 18563 NCBI Gene Model | MGI Sequence Detail 111281 C57BL/6J ±  kb
transcript NM_001162946 RefSeq | MGI Sequence Detail 4148 C57BL/6 
polypeptide Q05920 UniProt | EBI | MGI Sequence Detail 1178 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(10) UniProt(15)
Polymorphisms
SNPs within 2kb(423 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013785 Aldolase-type TIM barrel
InterPro IPR011761 ATP-grasp fold
InterPro IPR013815 ATP-grasp fold, subdomain 1
InterPro IPR013816 ATP-grasp fold, subdomain 2
InterPro IPR001882 Biotin-binding site
InterPro IPR005482 Biotin carboxylase, C-terminal
InterPro IPR011764 Biotin carboxylation domain
InterPro IPR000089 Biotin/lipoyl attachment
InterPro IPR005481 Carbamoyl-phosphate synthase, large subunit, N-terminal
InterPro IPR005479 Carbamoyl-phosphate synthetase large subunit-like, ATP-binding domain
InterPro IPR003379 Carboxylase, conserved domain
InterPro IPR009057 Homeodomain-like
InterPro IPR016185 Pre-ATP-grasp domain
InterPro IPR005930 Pyruvate carboxylase
InterPro IPR000891 Pyruvate carboxyltransferase
InterPro IPR011054 Rudiment single hybrid motif
InterPro IPR011053 Single hybrid motif
Protein Ontology PR:000012331 pyruvate carboxylase, mitochondrial
Graphical View of Protein Domain Structure
References
(Earliest) J:32775 Trigg M, New Mutations - provisional gene symbol act (adult cataract) and provisional gene symbol fp (flopsy). Mouse News Lett. 1972;47:19
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(48)
Other
accession IDs
MGD-MRK-13166, MGD-MRK-13201

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory