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Pcx Gene Detail
Summary
  • Symbol
    Pcx
  • Name
    pyruvate carboxylase
  • Synonyms
    Pc
  • Feature Type
    protein coding gene
  • IDs
    MGI:97520
    NCBI Gene: 18563
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:4510472-4621752 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.07 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    420 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97520
protein coding gene Chr19:4510472-4621752 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024666
protein coding gene Chr19:1387417-1508940 (+)
A/J MGP_AJ_G0024632
protein coding gene Chr19:1318278-1431991 (+)
AKR/J MGP_AKRJ_G0024605
protein coding gene Chr19:1358242-1473830 (+)
BALB/cJ MGP_BALBcJ_G0024632
protein coding gene Chr19:1314811-1427288 (+)
C3H/HeJ MGP_C3HHeJ_G0024400
protein coding gene Chr19:1363289-1480817 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025080
protein coding gene Chr19:1436894-1561183 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022509
protein coding gene Chr19:1258615-1367817 (+)
CAST/EiJ MGP_CASTEiJ_G0023872
protein coding gene Chr19:1371013-1490953 (+)
CBA/J MGP_CBAJ_G0024371
protein coding gene Chr19:1512966-1628353 (+)
DBA/2J MGP_DBA2J_G0024499
protein coding gene Chr19:1281024-1396000 (+)
FVB/NJ MGP_FVBNJ_G0024466
protein coding gene Chr19:1308757-1422153 (+)
LP/J MGP_LPJ_G0024585
protein coding gene Chr19:1401329-1517586 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024496
protein coding gene Chr19:1426130-1542323 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025127
protein coding gene Chr19:1360596-1472501 (+)
PWK/PhJ MGP_PWKPhJ_G0023618
protein coding gene Chr19:1338233-1454293 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023423
protein coding gene Chr19:1349621-1464672 (+)
WSB/EiJ MGP_WSBEiJ_G0023934
protein coding gene Chr19:1350669-1468139 (+)



Homology
more
  • Human Ortholog
    PC, pyruvate carboxylase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PC, pyruvate carboxylase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PCB
  • Links
    NCBI Gene ID: 5091
    neXtProt AC: NX_P11498
    UniProt: P11498

  • Chr Location
    11q13.2; chr11:66848522-66958418 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 5422
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: PC
  • Gene Tree
    Pcx
Human Diseases
more
  • Diseases
    1 with human PC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18563 NCBI Gene Model | MGI Sequence Detail 111281 C57BL/6J ±  kb
    transcript NM_001162946 RefSeq | MGI Sequence Detail 4148 C57BL/6  
    polypeptide Q05920 UniProt | EBI | MGI Sequence Detail 1178 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 125
      cDNA 124
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13166, MGD-MRK-13201
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 9
      Gene Ontology 10
      Phenotypes 11
    • Earliest
      J:15656 Freytag SO, et al., Molecular cloning of a cDNA for human pyruvate carboxylase. Structural relationship to other biotin-containing carboxylases and regulation of mRNA content in differentiating preadipocytes. J Biol Chem. 1984 Oct 25;259(20):12831-7
    • Latest
      J:249661 Schatton D, et al., CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs. J Cell Biol. 2017 Mar 06;216(3):675-693

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory